Association between apolipoprotein B gene polymorphisms and the risk of coronary heart disease (CHD): an update meta-analysis
Objective: Polymorphisms in the apolipoprotein B ( apo B) gene have been reported to be associated with coronary heart disease (CHD). However, the results on this topic are conflicting. The present study aims to derive a more precise estimation of the relationship between CHD and apo B genetic polym...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publications
2015-12-01
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| Series: | Journal of the Renin-Angiotensin-Aldosterone System |
| Online Access: | https://doi.org/10.1177/1470320315615047 |
| Summary: | Objective: Polymorphisms in the apolipoprotein B ( apo B) gene have been reported to be associated with coronary heart disease (CHD). However, the results on this topic are conflicting. The present study aims to derive a more precise estimation of the relationship between CHD and apo B genetic polymorphisms by meta-analysis. Methods: We identified a total of 54 studies involving 7236, 10,912, and 14,102 individuals, respectively, for EcoRI, XbaI, and SpIns/Del polymorphisms by searching in PubMed, Web of Science, Google Scholar, the Cochrane Library, Wanfang Data, SinoMed, and CNKI. We utilized RevMan 5.0 software to perform the meta-analyses. Results: A significant statistical association between apo B EcoRI polymorphism and CHD was observed under an allelic ( p = 0.001, odds ratio (OR) = 1.33, 95% confidence interval (CI) = 1.12–1.57), dominant ( p = 0.005, OR = 1.22, 95% CI = 1.06–1.40), and recessive ( p = 0.04, OR = 1.33, 95% CI = 1.01–1.74) model. We also found similar association of apo B SpIns/Del polymorphism with CHD. However, we did not find association between apo B XbaI polymorphism and CHD. Conclusion: The current meta-analysis found an association of EcoRI polymorphism and SpIns/Del polymorphism with an increased risk of CHD. No significant association between apo B XbaI polymorphism and CHD we observed in the present study. |
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| ISSN: | 1470-3203 1752-8976 |