Association between apolipoprotein B gene polymorphisms and the risk of coronary heart disease (CHD): an update meta-analysis
Objective: Polymorphisms in the apolipoprotein B ( apo B) gene have been reported to be associated with coronary heart disease (CHD). However, the results on this topic are conflicting. The present study aims to derive a more precise estimation of the relationship between CHD and apo B genetic polym...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publications
2015-12-01
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| Series: | Journal of the Renin-Angiotensin-Aldosterone System |
| Online Access: | https://doi.org/10.1177/1470320315615047 |
| _version_ | 1797284944260628480 |
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| author | Jing-Zhan Zhang Ying-Ying Zheng Yi-Ning Yang Xiao-Mei Li Zhen-Yan Fu Chuan-Fang Dai Fen Liu Bang-Dang Chen Min-Tao Gai Yi-Tong Ma Xiang Xie |
| author_facet | Jing-Zhan Zhang Ying-Ying Zheng Yi-Ning Yang Xiao-Mei Li Zhen-Yan Fu Chuan-Fang Dai Fen Liu Bang-Dang Chen Min-Tao Gai Yi-Tong Ma Xiang Xie |
| author_sort | Jing-Zhan Zhang |
| collection | DOAJ |
| description | Objective: Polymorphisms in the apolipoprotein B ( apo B) gene have been reported to be associated with coronary heart disease (CHD). However, the results on this topic are conflicting. The present study aims to derive a more precise estimation of the relationship between CHD and apo B genetic polymorphisms by meta-analysis. Methods: We identified a total of 54 studies involving 7236, 10,912, and 14,102 individuals, respectively, for EcoRI, XbaI, and SpIns/Del polymorphisms by searching in PubMed, Web of Science, Google Scholar, the Cochrane Library, Wanfang Data, SinoMed, and CNKI. We utilized RevMan 5.0 software to perform the meta-analyses. Results: A significant statistical association between apo B EcoRI polymorphism and CHD was observed under an allelic ( p = 0.001, odds ratio (OR) = 1.33, 95% confidence interval (CI) = 1.12–1.57), dominant ( p = 0.005, OR = 1.22, 95% CI = 1.06–1.40), and recessive ( p = 0.04, OR = 1.33, 95% CI = 1.01–1.74) model. We also found similar association of apo B SpIns/Del polymorphism with CHD. However, we did not find association between apo B XbaI polymorphism and CHD. Conclusion: The current meta-analysis found an association of EcoRI polymorphism and SpIns/Del polymorphism with an increased risk of CHD. No significant association between apo B XbaI polymorphism and CHD we observed in the present study. |
| first_indexed | 2024-03-07T17:55:08Z |
| format | Article |
| id | doaj.art-c8a43583d65840c69e503215344addab |
| institution | Directory Open Access Journal |
| issn | 1470-3203 1752-8976 |
| language | English |
| last_indexed | 2024-03-07T17:55:08Z |
| publishDate | 2015-12-01 |
| publisher | SAGE Publications |
| record_format | Article |
| series | Journal of the Renin-Angiotensin-Aldosterone System |
| spelling | doaj.art-c8a43583d65840c69e503215344addab2024-03-02T12:39:11ZengSAGE PublicationsJournal of the Renin-Angiotensin-Aldosterone System1470-32031752-89762015-12-011610.1177/1470320315615047Association between apolipoprotein B gene polymorphisms and the risk of coronary heart disease (CHD): an update meta-analysisJing-Zhan ZhangYing-Ying ZhengYi-Ning YangXiao-Mei LiZhen-Yan FuChuan-Fang DaiFen LiuBang-Dang ChenMin-Tao GaiYi-Tong MaXiang XieObjective: Polymorphisms in the apolipoprotein B ( apo B) gene have been reported to be associated with coronary heart disease (CHD). However, the results on this topic are conflicting. The present study aims to derive a more precise estimation of the relationship between CHD and apo B genetic polymorphisms by meta-analysis. Methods: We identified a total of 54 studies involving 7236, 10,912, and 14,102 individuals, respectively, for EcoRI, XbaI, and SpIns/Del polymorphisms by searching in PubMed, Web of Science, Google Scholar, the Cochrane Library, Wanfang Data, SinoMed, and CNKI. We utilized RevMan 5.0 software to perform the meta-analyses. Results: A significant statistical association between apo B EcoRI polymorphism and CHD was observed under an allelic ( p = 0.001, odds ratio (OR) = 1.33, 95% confidence interval (CI) = 1.12–1.57), dominant ( p = 0.005, OR = 1.22, 95% CI = 1.06–1.40), and recessive ( p = 0.04, OR = 1.33, 95% CI = 1.01–1.74) model. We also found similar association of apo B SpIns/Del polymorphism with CHD. However, we did not find association between apo B XbaI polymorphism and CHD. Conclusion: The current meta-analysis found an association of EcoRI polymorphism and SpIns/Del polymorphism with an increased risk of CHD. No significant association between apo B XbaI polymorphism and CHD we observed in the present study.https://doi.org/10.1177/1470320315615047 |
| spellingShingle | Jing-Zhan Zhang Ying-Ying Zheng Yi-Ning Yang Xiao-Mei Li Zhen-Yan Fu Chuan-Fang Dai Fen Liu Bang-Dang Chen Min-Tao Gai Yi-Tong Ma Xiang Xie Association between apolipoprotein B gene polymorphisms and the risk of coronary heart disease (CHD): an update meta-analysis Journal of the Renin-Angiotensin-Aldosterone System |
| title | Association between apolipoprotein B gene polymorphisms and the risk of coronary heart disease (CHD): an update meta-analysis |
| title_full | Association between apolipoprotein B gene polymorphisms and the risk of coronary heart disease (CHD): an update meta-analysis |
| title_fullStr | Association between apolipoprotein B gene polymorphisms and the risk of coronary heart disease (CHD): an update meta-analysis |
| title_full_unstemmed | Association between apolipoprotein B gene polymorphisms and the risk of coronary heart disease (CHD): an update meta-analysis |
| title_short | Association between apolipoprotein B gene polymorphisms and the risk of coronary heart disease (CHD): an update meta-analysis |
| title_sort | association between apolipoprotein b gene polymorphisms and the risk of coronary heart disease chd an update meta analysis |
| url | https://doi.org/10.1177/1470320315615047 |
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