Investigation of genotype diversity of 7,804 norovirus sequences in humans and animals of China
Norovirus is a prominent enteric virus responsible for severe acute gastroenteritis disease burden worldwide. In our current study, we analyzed 7,804 norovirus sequences of human and animals in China which were detected from 1980 to 2020 from GenBank. The GenBank database was searched up to May 2021...
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| Format: | Article |
| Language: | English |
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De Gruyter
2022-11-01
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| Series: | Open Life Sciences |
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| Online Access: | https://doi.org/10.1515/biol-2022-0511 |
| _version_ | 1828299409376411648 |
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| author | Li Manyu Li Kejian Lan Haiyun Hao Xiaotian Liu Yan Zhou Cheng |
| author_facet | Li Manyu Li Kejian Lan Haiyun Hao Xiaotian Liu Yan Zhou Cheng |
| author_sort | Li Manyu |
| collection | DOAJ |
| description | Norovirus is a prominent enteric virus responsible for severe acute gastroenteritis disease burden worldwide. In our current study, we analyzed 7,804 norovirus sequences of human and animals in China which were detected from 1980 to 2020 from GenBank. The GenBank database was searched up to May 2021 with the following search terms: “norovirus” or “norwalk virus” and “China.” The 7,804 norovirus sequences were collected and evaluated by phylogenetic analysis using MEGA X software package. The online typing tool (https://www.rivm.nl/mpf/typingtool/norovirus/) was used to confirm the genotypes. There were 36 norovirus genotypes prevailing in China. GII.4 was the most prevalent genotype, and GII.2, GII.3 and GII.17 also emerged during different time periods. Most sequences were detected in East China (41.72%, 3,256/7,804), but different norovirus genotypes were distributed widely across the country. A variety of norovirus genotypes, including GI, GII, GIII, GIV, GV, GVI, GVII and GX, were reported in different animals. Furthermore, a GI.3 sequence detected from animal had high identity with norovirus detected in human from the same region, indicating the potential norovirus zoonotic transmission in China. In conclusion, these results indicated that norovirus sequences with considerable genetic diversity distributed widely in China, with potential reverse zoonotic transmission from human to animals. |
| first_indexed | 2024-04-13T12:55:12Z |
| format | Article |
| id | doaj.art-c8a49a4d279145ff854e54ba64c9da92 |
| institution | Directory Open Access Journal |
| issn | 2391-5412 |
| language | English |
| last_indexed | 2024-04-13T12:55:12Z |
| publishDate | 2022-11-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Open Life Sciences |
| spelling | doaj.art-c8a49a4d279145ff854e54ba64c9da922022-12-22T02:46:05ZengDe GruyterOpen Life Sciences2391-54122022-11-011711429143510.1515/biol-2022-0511Investigation of genotype diversity of 7,804 norovirus sequences in humans and animals of ChinaLi Manyu0Li Kejian1Lan Haiyun2Hao Xiaotian3Liu Yan4Zhou Cheng5Division I of In Vitro Diagnostics for Infectious Diseases, Institute for In Vitro Diagnostics Control, National Institutes for Food and Drug Control, 2 Tiantanxili Rd, Dongcheng District, Beijing 100050, ChinaDivision I of In Vitro Diagnostics for Infectious Diseases, Institute for In Vitro Diagnostics Control, National Institutes for Food and Drug Control, Dongcheng District, Beijing 100050, ChinaDivision I of In Vitro Diagnostics for Infectious Diseases, Institute for In Vitro Diagnostics Control, National Institutes for Food and Drug Control, Dongcheng District, Beijing 100050, ChinaDivision I of In Vitro Diagnostics for Infectious Diseases, Institute for In Vitro Diagnostics Control, National Institutes for Food and Drug Control, Dongcheng District, Beijing 100050, ChinaDivision I of In Vitro Diagnostics for Infectious Diseases, Institute for In Vitro Diagnostics Control, National Institutes for Food and Drug Control, Dongcheng District, Beijing 100050, ChinaDivision I of In Vitro Diagnostics for Infectious Diseases, Institute for In Vitro Diagnostics Control, National Institutes for Food and Drug Control, 2 Tiantanxili Rd, Dongcheng District, Beijing 100050, ChinaNorovirus is a prominent enteric virus responsible for severe acute gastroenteritis disease burden worldwide. In our current study, we analyzed 7,804 norovirus sequences of human and animals in China which were detected from 1980 to 2020 from GenBank. The GenBank database was searched up to May 2021 with the following search terms: “norovirus” or “norwalk virus” and “China.” The 7,804 norovirus sequences were collected and evaluated by phylogenetic analysis using MEGA X software package. The online typing tool (https://www.rivm.nl/mpf/typingtool/norovirus/) was used to confirm the genotypes. There were 36 norovirus genotypes prevailing in China. GII.4 was the most prevalent genotype, and GII.2, GII.3 and GII.17 also emerged during different time periods. Most sequences were detected in East China (41.72%, 3,256/7,804), but different norovirus genotypes were distributed widely across the country. A variety of norovirus genotypes, including GI, GII, GIII, GIV, GV, GVI, GVII and GX, were reported in different animals. Furthermore, a GI.3 sequence detected from animal had high identity with norovirus detected in human from the same region, indicating the potential norovirus zoonotic transmission in China. In conclusion, these results indicated that norovirus sequences with considerable genetic diversity distributed widely in China, with potential reverse zoonotic transmission from human to animals.https://doi.org/10.1515/biol-2022-0511genotype diversitynoroviruszoonosis |
| spellingShingle | Li Manyu Li Kejian Lan Haiyun Hao Xiaotian Liu Yan Zhou Cheng Investigation of genotype diversity of 7,804 norovirus sequences in humans and animals of China Open Life Sciences genotype diversity norovirus zoonosis |
| title | Investigation of genotype diversity of 7,804 norovirus sequences in humans and animals of China |
| title_full | Investigation of genotype diversity of 7,804 norovirus sequences in humans and animals of China |
| title_fullStr | Investigation of genotype diversity of 7,804 norovirus sequences in humans and animals of China |
| title_full_unstemmed | Investigation of genotype diversity of 7,804 norovirus sequences in humans and animals of China |
| title_short | Investigation of genotype diversity of 7,804 norovirus sequences in humans and animals of China |
| title_sort | investigation of genotype diversity of 7 804 norovirus sequences in humans and animals of china |
| topic | genotype diversity norovirus zoonosis |
| url | https://doi.org/10.1515/biol-2022-0511 |
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