Case report: BCL-2 and CD31 immunoexpression related to clinical and histopathological evaluation of renal dysplasia in a Welsh Corgi Puppy
A case of renal dysplasia (RD) in the Welsh Corgi dog has been reported. Clinically, the affected 3-month-old, female, Welsh Corgi dog showed unclear symptoms of chronic kidney disease. Grossly, both left and right kidneys revealed cystic hypoplasia. Histologically, the primary lesions included imma...
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| Format: | Article |
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Frontiers Media S.A.
2022-10-01
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| Series: | Frontiers in Veterinary Science |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fvets.2022.995765/full |
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| author | Trung Quang Le Trung Quang Le Latticha Pluemhathaikij Katriya Chankow Araya Radtanakatikanon Anudep Rungsipipat Kasem Rattanapinyopituk |
| author_facet | Trung Quang Le Trung Quang Le Latticha Pluemhathaikij Katriya Chankow Araya Radtanakatikanon Anudep Rungsipipat Kasem Rattanapinyopituk |
| author_sort | Trung Quang Le |
| collection | DOAJ |
| description | A case of renal dysplasia (RD) in the Welsh Corgi dog has been reported. Clinically, the affected 3-month-old, female, Welsh Corgi dog showed unclear symptoms of chronic kidney disease. Grossly, both left and right kidneys revealed cystic hypoplasia. Histologically, the primary lesions included immature or fetal glomeruli/tubules, proliferative arterioles, persistent metanephric ducts, persistent mesenchyme, and atypical tubular epithelium were presented. A group of degenerative and inflammatory lesions consisting of interstitial nephritis, interstitial fibrosis, and mineralization of tubules were found. Immunohistochemically, the epithelial cells of immature (fetal) tubules had BCL-2 labeling whereas CD31 (PECAM-1) was labeled in the endothelial cells of the proliferative arterioles. The immunohistochemical findings were confirmed and consolidated with the routine histopathological findings. This study was the first demonstration of the clinical, histopathological, and immunohistochemical features of RD disease in a Welsh Corgi puppy. |
| first_indexed | 2024-04-12T13:56:18Z |
| format | Article |
| id | doaj.art-c8a5c0aa48e14c61bdd8d4c2c39adc51 |
| institution | Directory Open Access Journal |
| issn | 2297-1769 |
| language | English |
| last_indexed | 2024-04-12T13:56:18Z |
| publishDate | 2022-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Veterinary Science |
| spelling | doaj.art-c8a5c0aa48e14c61bdd8d4c2c39adc512022-12-22T03:30:21ZengFrontiers Media S.A.Frontiers in Veterinary Science2297-17692022-10-01910.3389/fvets.2022.995765995765Case report: BCL-2 and CD31 immunoexpression related to clinical and histopathological evaluation of renal dysplasia in a Welsh Corgi PuppyTrung Quang Le0Trung Quang Le1Latticha Pluemhathaikij2Katriya Chankow3Araya Radtanakatikanon4Anudep Rungsipipat5Kasem Rattanapinyopituk6Center of Excellent for Companion Animal Cancer - (CECAC), Department of Veterinary Pathology, Chulalongkorn University, Bangkok, ThailandDepartment of Veterinary Medicine, Can Tho University, Can Tho, VietnamDepartment of Veterinary Pathology, Chulalongkorn University, Bangkok, ThailandDepartment of Veterinary Pathology, Chulalongkorn University, Bangkok, ThailandCenter of Excellent for Companion Animal Cancer - (CECAC), Department of Veterinary Pathology, Chulalongkorn University, Bangkok, ThailandCenter of Excellent for Companion Animal Cancer - (CECAC), Department of Veterinary Pathology, Chulalongkorn University, Bangkok, ThailandCenter of Excellent for Companion Animal Cancer - (CECAC), Department of Veterinary Pathology, Chulalongkorn University, Bangkok, ThailandA case of renal dysplasia (RD) in the Welsh Corgi dog has been reported. Clinically, the affected 3-month-old, female, Welsh Corgi dog showed unclear symptoms of chronic kidney disease. Grossly, both left and right kidneys revealed cystic hypoplasia. Histologically, the primary lesions included immature or fetal glomeruli/tubules, proliferative arterioles, persistent metanephric ducts, persistent mesenchyme, and atypical tubular epithelium were presented. A group of degenerative and inflammatory lesions consisting of interstitial nephritis, interstitial fibrosis, and mineralization of tubules were found. Immunohistochemically, the epithelial cells of immature (fetal) tubules had BCL-2 labeling whereas CD31 (PECAM-1) was labeled in the endothelial cells of the proliferative arterioles. The immunohistochemical findings were confirmed and consolidated with the routine histopathological findings. This study was the first demonstration of the clinical, histopathological, and immunohistochemical features of RD disease in a Welsh Corgi puppy.https://www.frontiersin.org/articles/10.3389/fvets.2022.995765/fullcaninerenal dysplasiaWelsh CorgihistopathologyBCL-2CD31 |
| spellingShingle | Trung Quang Le Trung Quang Le Latticha Pluemhathaikij Katriya Chankow Araya Radtanakatikanon Anudep Rungsipipat Kasem Rattanapinyopituk Case report: BCL-2 and CD31 immunoexpression related to clinical and histopathological evaluation of renal dysplasia in a Welsh Corgi Puppy Frontiers in Veterinary Science canine renal dysplasia Welsh Corgi histopathology BCL-2 CD31 |
| title | Case report: BCL-2 and CD31 immunoexpression related to clinical and histopathological evaluation of renal dysplasia in a Welsh Corgi Puppy |
| title_full | Case report: BCL-2 and CD31 immunoexpression related to clinical and histopathological evaluation of renal dysplasia in a Welsh Corgi Puppy |
| title_fullStr | Case report: BCL-2 and CD31 immunoexpression related to clinical and histopathological evaluation of renal dysplasia in a Welsh Corgi Puppy |
| title_full_unstemmed | Case report: BCL-2 and CD31 immunoexpression related to clinical and histopathological evaluation of renal dysplasia in a Welsh Corgi Puppy |
| title_short | Case report: BCL-2 and CD31 immunoexpression related to clinical and histopathological evaluation of renal dysplasia in a Welsh Corgi Puppy |
| title_sort | case report bcl 2 and cd31 immunoexpression related to clinical and histopathological evaluation of renal dysplasia in a welsh corgi puppy |
| topic | canine renal dysplasia Welsh Corgi histopathology BCL-2 CD31 |
| url | https://www.frontiersin.org/articles/10.3389/fvets.2022.995765/full |
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