The peptidyl prolyl cis/trans isomerase Pin1/Ess1 inhibits phosphorylation and toxicity of tau in a yeast model for Alzheimer’s disease

The peptidyl prolyl cis/trans isomerase Pin1/Ess1 inhibits phosphorylation and toxicity of tau in a yeast model for Alzheimer’s disease

Since hyperphosphorylation of protein tau is a crucial event in Alzheimer’s disease, additional mechanisms besides the interplay of kinase and phosphatase activities are investigated, such as the effect of the peptidyl prolyl cis/trans isomerase Pin1. This isomerase was shown to bind and isomerize p...

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Dettagli Bibliografici
Autori principali:	Ann De Vos, Tine Bynens, Joëlle Rosseels, Catherina Coun, Julia Ring, Frank Madeo, Marie-Christine Galas, Joris Winderickx, Vanessa Franssens
Natura:	Articolo
Lingua:	English
Pubblicazione:	AIMS Press 2015-04-01
Serie:	AIMS Molecular Science
Soggetti:	Pin1 tau yeast phosphorylation Alzheimer’s dis Alzheimer’s disease
Accesso online:	http://www.aimspress.com/article/10.3934/molsci.2015.2.144/fulltext.html

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