The association between regional transcriptome profiles and lung volumes in response to mechanical ventilation and lung injury

The association between regional transcriptome profiles and lung volumes in response to mechanical ventilation and lung injury

Abstract Background Lung inhomogeneity plays a pivotal role in the development of ventilator-induced lung injury (VILI), particularly in the context of pre-existing lung injury. The mechanisms that underlie this interaction are poorly understood. We aimed to elucidate the regional transcriptomic res...

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Bibliographic Details
Main Authors: Yong Song, Seiha Yen, Melissa Preissner, Ellen Bennett, Stephen Dubsky, Andreas Fouras, Peter A. Dargaville, Graeme R. Zosky
Format: Article
Language:English
Published: BMC 2022-02-01
Series:Respiratory Research
Subjects:
Mechanical ventilation
Ventilator-induced lung injury
Sepsis
Lung inhomogeneities
RNA sequencing
Transcriptome
Online Access:https://doi.org/10.1186/s12931-022-01958-2

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