Central Nervous System Parasitosis and Neuroinflammation Ameliorated by Systemic IL-10 Administration in Trypanosoma brucei-Infected Mice.
Invasion of the central nervous system (CNS) by African trypanosomes represents a critical step in the development of human African trypanosomiasis. In both clinical cases and experimental mouse infections it has been demonstrated that predisposition to CNS invasion is associated with a type 1 syste...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2015-01-01
|
| Series: | PLoS Neglected Tropical Diseases |
| Online Access: | http://europepmc.org/articles/PMC4624684?pdf=render |
| _version_ | 1811268676552228864 |
|---|---|
| author | Jean Rodgers Barbara Bradley Peter G E Kennedy Jeremy M Sternberg |
| author_facet | Jean Rodgers Barbara Bradley Peter G E Kennedy Jeremy M Sternberg |
| author_sort | Jean Rodgers |
| collection | DOAJ |
| description | Invasion of the central nervous system (CNS) by African trypanosomes represents a critical step in the development of human African trypanosomiasis. In both clinical cases and experimental mouse infections it has been demonstrated that predisposition to CNS invasion is associated with a type 1 systemic inflammatory response. Using the Trypanosoma brucei brucei GVR35 experimental infection model, we demonstrate that systemic delivery of the counter-inflammatory cytokine IL-10 lowers plasma IFN-γ and TNF-α concentrations, CNS parasitosis and ameliorates neuro-inflammatory pathology and clinical symptoms of disease. The results provide evidence that CNS invasion may be susceptible to immunological attenuation. |
| first_indexed | 2024-04-12T21:27:09Z |
| format | Article |
| id | doaj.art-c8aa2a21758b4583bd1549903bb696e4 |
| institution | Directory Open Access Journal |
| issn | 1935-2727 1935-2735 |
| language | English |
| last_indexed | 2024-04-12T21:27:09Z |
| publishDate | 2015-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Neglected Tropical Diseases |
| spelling | doaj.art-c8aa2a21758b4583bd1549903bb696e42022-12-22T03:16:08ZengPublic Library of Science (PLoS)PLoS Neglected Tropical Diseases1935-27271935-27352015-01-01910e000420110.1371/journal.pntd.0004201Central Nervous System Parasitosis and Neuroinflammation Ameliorated by Systemic IL-10 Administration in Trypanosoma brucei-Infected Mice.Jean RodgersBarbara BradleyPeter G E KennedyJeremy M SternbergInvasion of the central nervous system (CNS) by African trypanosomes represents a critical step in the development of human African trypanosomiasis. In both clinical cases and experimental mouse infections it has been demonstrated that predisposition to CNS invasion is associated with a type 1 systemic inflammatory response. Using the Trypanosoma brucei brucei GVR35 experimental infection model, we demonstrate that systemic delivery of the counter-inflammatory cytokine IL-10 lowers plasma IFN-γ and TNF-α concentrations, CNS parasitosis and ameliorates neuro-inflammatory pathology and clinical symptoms of disease. The results provide evidence that CNS invasion may be susceptible to immunological attenuation.http://europepmc.org/articles/PMC4624684?pdf=render |
| spellingShingle | Jean Rodgers Barbara Bradley Peter G E Kennedy Jeremy M Sternberg Central Nervous System Parasitosis and Neuroinflammation Ameliorated by Systemic IL-10 Administration in Trypanosoma brucei-Infected Mice. PLoS Neglected Tropical Diseases |
| title | Central Nervous System Parasitosis and Neuroinflammation Ameliorated by Systemic IL-10 Administration in Trypanosoma brucei-Infected Mice. |
| title_full | Central Nervous System Parasitosis and Neuroinflammation Ameliorated by Systemic IL-10 Administration in Trypanosoma brucei-Infected Mice. |
| title_fullStr | Central Nervous System Parasitosis and Neuroinflammation Ameliorated by Systemic IL-10 Administration in Trypanosoma brucei-Infected Mice. |
| title_full_unstemmed | Central Nervous System Parasitosis and Neuroinflammation Ameliorated by Systemic IL-10 Administration in Trypanosoma brucei-Infected Mice. |
| title_short | Central Nervous System Parasitosis and Neuroinflammation Ameliorated by Systemic IL-10 Administration in Trypanosoma brucei-Infected Mice. |
| title_sort | central nervous system parasitosis and neuroinflammation ameliorated by systemic il 10 administration in trypanosoma brucei infected mice |
| url | http://europepmc.org/articles/PMC4624684?pdf=render |
| work_keys_str_mv | AT jeanrodgers centralnervoussystemparasitosisandneuroinflammationamelioratedbysystemicil10administrationintrypanosomabruceiinfectedmice AT barbarabradley centralnervoussystemparasitosisandneuroinflammationamelioratedbysystemicil10administrationintrypanosomabruceiinfectedmice AT petergekennedy centralnervoussystemparasitosisandneuroinflammationamelioratedbysystemicil10administrationintrypanosomabruceiinfectedmice AT jeremymsternberg centralnervoussystemparasitosisandneuroinflammationamelioratedbysystemicil10administrationintrypanosomabruceiinfectedmice |