The Role of Alteration of Glutamic Acid and Gaba in Learning and Memory Impairment of Rats Induced by Aluminum
Aluminum exposure has been reported to be related to learning and memory impairment. This study examines the role of aluminum in alterating amino acids of the cerebral cortex of rats. The Step-down type tests were performed to investigate the alteration of learning and memory of rats induced by alum...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2005-05-01
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| Series: | European Journal of Inflammation |
| Online Access: | https://doi.org/10.1177/1721727X0500300207 |
| _version_ | 1818350086165364736 |
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| author | Q. Niu P. Niu Q. Zhang L. Wang S. He M. Di Gioacchino P. Boscolo |
| author_facet | Q. Niu P. Niu Q. Zhang L. Wang S. He M. Di Gioacchino P. Boscolo |
| author_sort | Q. Niu |
| collection | DOAJ |
| description | Aluminum exposure has been reported to be related to learning and memory impairment. This study examines the role of aluminum in alterating amino acids of the cerebral cortex of rats. The Step-down type tests were performed to investigate the alteration of learning and memory of rats induced by aluminum. The amino acids in the cerebral cortex were detected by high performance liquid chromatography (HLPC). Results show that the amounts of aluminum in the cerebral cortex increased by 5.0mgAl3+/(Kg·BW) group and 10.0mg Al3+/(Kg·BW) group. In the Step-down type test, the EN1 increased significantly in the Al3+ 10.0mg/(Kg·BW) group. The latency shortened obviously and the EN2 increased significantly in the 10.0mg Al3+/(Kg·BW) group. The content of Glu (Glutamic acid) increased but the content of GABA (gamma-aminobutyric acid) decreased significantly in the 10.0mg Al3+/(Kg·BW) group. This present study shows evidence that the disorder of amino acid neurotransmitters system plays an important role in the impairment of learning and memory of rats induced by aluminum. |
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| id | doaj.art-c8ad741e41ac4392bd9732753f614138 |
| institution | Directory Open Access Journal |
| issn | 1721-727X |
| language | English |
| last_indexed | 2024-12-13T18:16:15Z |
| publishDate | 2005-05-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | European Journal of Inflammation |
| spelling | doaj.art-c8ad741e41ac4392bd9732753f6141382022-12-21T23:35:50ZengSAGE PublishingEuropean Journal of Inflammation1721-727X2005-05-01310.1177/1721727X0500300207The Role of Alteration of Glutamic Acid and Gaba in Learning and Memory Impairment of Rats Induced by AluminumQ. NiuP. NiuQ. ZhangL. WangS. HeM. Di Gioacchino0P. Boscolo1 University G. D'Annunzio, Chieti, Italy University G. D'Annunzio, Chieti, ItalyAluminum exposure has been reported to be related to learning and memory impairment. This study examines the role of aluminum in alterating amino acids of the cerebral cortex of rats. The Step-down type tests were performed to investigate the alteration of learning and memory of rats induced by aluminum. The amino acids in the cerebral cortex were detected by high performance liquid chromatography (HLPC). Results show that the amounts of aluminum in the cerebral cortex increased by 5.0mgAl3+/(Kg·BW) group and 10.0mg Al3+/(Kg·BW) group. In the Step-down type test, the EN1 increased significantly in the Al3+ 10.0mg/(Kg·BW) group. The latency shortened obviously and the EN2 increased significantly in the 10.0mg Al3+/(Kg·BW) group. The content of Glu (Glutamic acid) increased but the content of GABA (gamma-aminobutyric acid) decreased significantly in the 10.0mg Al3+/(Kg·BW) group. This present study shows evidence that the disorder of amino acid neurotransmitters system plays an important role in the impairment of learning and memory of rats induced by aluminum.https://doi.org/10.1177/1721727X0500300207 |
| spellingShingle | Q. Niu P. Niu Q. Zhang L. Wang S. He M. Di Gioacchino P. Boscolo The Role of Alteration of Glutamic Acid and Gaba in Learning and Memory Impairment of Rats Induced by Aluminum European Journal of Inflammation |
| title | The Role of Alteration of Glutamic Acid and Gaba in Learning and Memory Impairment of Rats Induced by Aluminum |
| title_full | The Role of Alteration of Glutamic Acid and Gaba in Learning and Memory Impairment of Rats Induced by Aluminum |
| title_fullStr | The Role of Alteration of Glutamic Acid and Gaba in Learning and Memory Impairment of Rats Induced by Aluminum |
| title_full_unstemmed | The Role of Alteration of Glutamic Acid and Gaba in Learning and Memory Impairment of Rats Induced by Aluminum |
| title_short | The Role of Alteration of Glutamic Acid and Gaba in Learning and Memory Impairment of Rats Induced by Aluminum |
| title_sort | role of alteration of glutamic acid and gaba in learning and memory impairment of rats induced by aluminum |
| url | https://doi.org/10.1177/1721727X0500300207 |
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