Osteoblast lineage Sod2 deficiency leads to an osteoporosis-like phenotype in mice

Osteoblast lineage Sod2 deficiency leads to an osteoporosis-like phenotype in mice

Osteoporosis is a systemic metabolic skeletal disease characterized by low bone mass and strength associated with fragility fractures. Oxidative stress, which results from elevated intracellular reactive oxygen species (ROS) and arises in the aging organism, is considered one of the critical factors...

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Bibliographic Details
Main Authors: Astrid M. Schoppa, Xiangxu Chen, Jan-Moritz Ramge, Anna Vikman, Verena Fischer, Melanie Haffner-Luntzer, Jana Riegger, Jan Tuckermann, Karin Scharffetter-Kochanek, Anita Ignatius
Format: Article
Language:English
Published: The Company of Biologists 2022-05-01
Series:Disease Models & Mechanisms
Subjects:
skeletal aging
osteoporosis
mitochondrial dysfunction
reactive oxygen species
senescence
Online Access:http://dmm.biologists.org/content/15/5/dmm049392

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