Research progress on nanocellulose and its composite materials as orthopedic implant biomaterials
This review summarizes recent progress on nanocellulose and its composite materials as emerging biomaterials for orthopedic implant applications. The three main types of nanocellulose - cellulose nanocrystals (CNCs), cellulose nanofibrils (CNFs) and bacterial nanocellulose (BNC) possess exceptional...
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| Format: | Article |
| Jezik: | English |
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Elsevier
2024-01-01
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| Serija: | Alexandria Engineering Journal |
| Teme: | |
| Online dostop: | http://www.sciencedirect.com/science/article/pii/S1110016824000036 |
| _version_ | 1827370680611504128 |
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| author | Tiehui Shen Hao Dong Pan Wang |
| author_facet | Tiehui Shen Hao Dong Pan Wang |
| author_sort | Tiehui Shen |
| collection | DOAJ |
| description | This review summarizes recent progress on nanocellulose and its composite materials as emerging biomaterials for orthopedic implant applications. The three main types of nanocellulose - cellulose nanocrystals (CNCs), cellulose nanofibrils (CNFs) and bacterial nanocellulose (BNC) possess exceptional mechanical properties exceeding traditional implant materials like metals, ceramics and polymers. Their high strength, stiffness, porosity, surface area, hydrophilicity and biocompatibility make nanocellulose well-suited as a scaffold material for bone regeneration. This review covers the fabrication of nanocellulose-based composites with ceramics and polymers to further enhance their mechanical performance and bioactivity. Various methods are utilized to develop nanocellulose implants and scaffolds with controlled architecture optimized for bone ingrowth. In vitro studies demonstrate nanocellulose supports stem cell osteogenic differentiation and growth. In vivo results in animal models show bone regeneration in critical sized defects, though challenges remain in vascularization. While further research is required to control degradation and scale up manufacturing, nanocellulose has strong potential to address limitations of current orthopedic implants as the next generation of high performance biomaterials. This review provides a comprehensive perspective on the state-of-the-art in nanocellulose materials for advanced orthopedic implants. |
| first_indexed | 2024-03-08T10:19:08Z |
| format | Article |
| id | doaj.art-c8b0d83c3b554d2faa1de656da018d74 |
| institution | Directory Open Access Journal |
| issn | 1110-0168 |
| language | English |
| last_indexed | 2024-03-08T10:19:08Z |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Alexandria Engineering Journal |
| spelling | doaj.art-c8b0d83c3b554d2faa1de656da018d742024-01-28T04:21:13ZengElsevierAlexandria Engineering Journal1110-01682024-01-0187575590Research progress on nanocellulose and its composite materials as orthopedic implant biomaterialsTiehui Shen0Hao Dong1Pan Wang2Department of Trauma Orthopedics, Zibo Central Hospital, Zibo, Shandong 255000, PR ChinaDepartment of Trauma Orthopedics, Zibo Central Hospital, Zibo, Shandong 255000, PR ChinaDepartment of Pain, Zibo Central Hospital, Zibo, Shandong 255000, PR China; Corresponding author.This review summarizes recent progress on nanocellulose and its composite materials as emerging biomaterials for orthopedic implant applications. The three main types of nanocellulose - cellulose nanocrystals (CNCs), cellulose nanofibrils (CNFs) and bacterial nanocellulose (BNC) possess exceptional mechanical properties exceeding traditional implant materials like metals, ceramics and polymers. Their high strength, stiffness, porosity, surface area, hydrophilicity and biocompatibility make nanocellulose well-suited as a scaffold material for bone regeneration. This review covers the fabrication of nanocellulose-based composites with ceramics and polymers to further enhance their mechanical performance and bioactivity. Various methods are utilized to develop nanocellulose implants and scaffolds with controlled architecture optimized for bone ingrowth. In vitro studies demonstrate nanocellulose supports stem cell osteogenic differentiation and growth. In vivo results in animal models show bone regeneration in critical sized defects, though challenges remain in vascularization. While further research is required to control degradation and scale up manufacturing, nanocellulose has strong potential to address limitations of current orthopedic implants as the next generation of high performance biomaterials. This review provides a comprehensive perspective on the state-of-the-art in nanocellulose materials for advanced orthopedic implants.http://www.sciencedirect.com/science/article/pii/S1110016824000036NanocelluloseOrthopedic implantBiomaterialCompositeBone regeneration |
| spellingShingle | Tiehui Shen Hao Dong Pan Wang Research progress on nanocellulose and its composite materials as orthopedic implant biomaterials Alexandria Engineering Journal Nanocellulose Orthopedic implant Biomaterial Composite Bone regeneration |
| title | Research progress on nanocellulose and its composite materials as orthopedic implant biomaterials |
| title_full | Research progress on nanocellulose and its composite materials as orthopedic implant biomaterials |
| title_fullStr | Research progress on nanocellulose and its composite materials as orthopedic implant biomaterials |
| title_full_unstemmed | Research progress on nanocellulose and its composite materials as orthopedic implant biomaterials |
| title_short | Research progress on nanocellulose and its composite materials as orthopedic implant biomaterials |
| title_sort | research progress on nanocellulose and its composite materials as orthopedic implant biomaterials |
| topic | Nanocellulose Orthopedic implant Biomaterial Composite Bone regeneration |
| url | http://www.sciencedirect.com/science/article/pii/S1110016824000036 |
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