Field efficacy of a new mosaic long-lasting mosquito net (PermaNet<sup>® </sup>3.0) against pyrethroid-resistant malaria vectors: a multi centre study in Western and Central Africa

<p>Abstract</p> <p>Background</p> <p>Due to the spread of pyrethroid-resistance in malaria vectors in Africa, new strategies and tools are urgently needed to better control malaria transmission. The aim of this study was to evaluate the performances of a new mosaic long...

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Bibliographic Details
Main Authors: Pigeon Olivier, Nwane Philippe, Etang Josiane, Dabiré Roch K, Chabi Joseph, Corbel Vincent, Akogbeto Martin, Hougard Jean-Marc
Format: Article
Language:English
Published: BMC 2010-04-01
Series:Malaria Journal
Online Access:http://www.malariajournal.com/content/9/1/113
Description
Summary:<p>Abstract</p> <p>Background</p> <p>Due to the spread of pyrethroid-resistance in malaria vectors in Africa, new strategies and tools are urgently needed to better control malaria transmission. The aim of this study was to evaluate the performances of a new mosaic long-lasting insecticidal net (LLIN), i.e. PermaNet<sup>® </sup>3.0, against wild pyrethroid-resistant <it>Anopheles gambiae s.l</it>. in West and Central Africa.</p> <p>Methods</p> <p>A multi centre experimental hut trial was conducted in Malanville (Benin), Vallée du Kou (Burkina Faso) and Pitoa (Cameroon) to investigate the exophily, blood feeding inhibition and mortality induced by PermaNet<sup>® </sup>3.0 (i.e. a mosaic net containing piperonyl butoxide and deltamethrin on the roof) comparatively to the WHO recommended PermaNet<sup>® </sup>2.0 (unwashed and washed 20-times) and a conventionally deltamethrin-treated net (CTN).</p> <p>Results</p> <p>The personal protection and insecticidal activity of PermaNet 3.0 and PermaNet<sup>® </sup>2.0 were excellent (>80%) in the "pyrethroid-tolerant" area of Malanville. In the pyrethroid-resistance areas of Pitoa (metabolic resistance) and Vallée du Kou (presence of the L1014F <it>kdr </it>mutation), PermaNet<sup>® </sup>3.0 showed equal or better performances than PermaNet<sup>® </sup>2.0. It should be noted however that the deltamethrin content on PermaNet<sup>® </sup>3.0 was up to twice higher than that of PermaNet<sup>® </sup>2.0. Significant reduction of efficacy of both LLIN was noted after 20 washes although PermaNet<sup>® </sup>3.0 still fulfilled the WHO requirement for LLIN.</p> <p>Conclusion</p> <p>The use of combination nets for malaria control offers promising prospects. However, further investigations are needed to demonstrate the benefits of using PermaNet<sup>® </sup>3.0 for the control of pyrethroid resistant mosquito populations in Africa.</p>
ISSN:1475-2875