Field efficacy of a new mosaic long-lasting mosquito net (PermaNet<sup>® </sup>3.0) against pyrethroid-resistant malaria vectors: a multi centre study in Western and Central Africa
<p>Abstract</p> <p>Background</p> <p>Due to the spread of pyrethroid-resistance in malaria vectors in Africa, new strategies and tools are urgently needed to better control malaria transmission. The aim of this study was to evaluate the performances of a new mosaic long...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2010-04-01
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| Series: | Malaria Journal |
| Online Access: | http://www.malariajournal.com/content/9/1/113 |
| _version_ | 1819086051968286720 |
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| author | Pigeon Olivier Nwane Philippe Etang Josiane Dabiré Roch K Chabi Joseph Corbel Vincent Akogbeto Martin Hougard Jean-Marc |
| author_facet | Pigeon Olivier Nwane Philippe Etang Josiane Dabiré Roch K Chabi Joseph Corbel Vincent Akogbeto Martin Hougard Jean-Marc |
| author_sort | Pigeon Olivier |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Due to the spread of pyrethroid-resistance in malaria vectors in Africa, new strategies and tools are urgently needed to better control malaria transmission. The aim of this study was to evaluate the performances of a new mosaic long-lasting insecticidal net (LLIN), i.e. PermaNet<sup>® </sup>3.0, against wild pyrethroid-resistant <it>Anopheles gambiae s.l</it>. in West and Central Africa.</p> <p>Methods</p> <p>A multi centre experimental hut trial was conducted in Malanville (Benin), Vallée du Kou (Burkina Faso) and Pitoa (Cameroon) to investigate the exophily, blood feeding inhibition and mortality induced by PermaNet<sup>® </sup>3.0 (i.e. a mosaic net containing piperonyl butoxide and deltamethrin on the roof) comparatively to the WHO recommended PermaNet<sup>® </sup>2.0 (unwashed and washed 20-times) and a conventionally deltamethrin-treated net (CTN).</p> <p>Results</p> <p>The personal protection and insecticidal activity of PermaNet 3.0 and PermaNet<sup>® </sup>2.0 were excellent (>80%) in the "pyrethroid-tolerant" area of Malanville. In the pyrethroid-resistance areas of Pitoa (metabolic resistance) and Vallée du Kou (presence of the L1014F <it>kdr </it>mutation), PermaNet<sup>® </sup>3.0 showed equal or better performances than PermaNet<sup>® </sup>2.0. It should be noted however that the deltamethrin content on PermaNet<sup>® </sup>3.0 was up to twice higher than that of PermaNet<sup>® </sup>2.0. Significant reduction of efficacy of both LLIN was noted after 20 washes although PermaNet<sup>® </sup>3.0 still fulfilled the WHO requirement for LLIN.</p> <p>Conclusion</p> <p>The use of combination nets for malaria control offers promising prospects. However, further investigations are needed to demonstrate the benefits of using PermaNet<sup>® </sup>3.0 for the control of pyrethroid resistant mosquito populations in Africa.</p> |
| first_indexed | 2024-12-21T21:14:07Z |
| format | Article |
| id | doaj.art-c8b1796897d24ea6953a41e1ade4f993 |
| institution | Directory Open Access Journal |
| issn | 1475-2875 |
| language | English |
| last_indexed | 2024-12-21T21:14:07Z |
| publishDate | 2010-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Malaria Journal |
| spelling | doaj.art-c8b1796897d24ea6953a41e1ade4f9932022-12-21T18:50:03ZengBMCMalaria Journal1475-28752010-04-019111310.1186/1475-2875-9-113Field efficacy of a new mosaic long-lasting mosquito net (PermaNet<sup>® </sup>3.0) against pyrethroid-resistant malaria vectors: a multi centre study in Western and Central AfricaPigeon OlivierNwane PhilippeEtang JosianeDabiré Roch KChabi JosephCorbel VincentAkogbeto MartinHougard Jean-Marc<p>Abstract</p> <p>Background</p> <p>Due to the spread of pyrethroid-resistance in malaria vectors in Africa, new strategies and tools are urgently needed to better control malaria transmission. The aim of this study was to evaluate the performances of a new mosaic long-lasting insecticidal net (LLIN), i.e. PermaNet<sup>® </sup>3.0, against wild pyrethroid-resistant <it>Anopheles gambiae s.l</it>. in West and Central Africa.</p> <p>Methods</p> <p>A multi centre experimental hut trial was conducted in Malanville (Benin), Vallée du Kou (Burkina Faso) and Pitoa (Cameroon) to investigate the exophily, blood feeding inhibition and mortality induced by PermaNet<sup>® </sup>3.0 (i.e. a mosaic net containing piperonyl butoxide and deltamethrin on the roof) comparatively to the WHO recommended PermaNet<sup>® </sup>2.0 (unwashed and washed 20-times) and a conventionally deltamethrin-treated net (CTN).</p> <p>Results</p> <p>The personal protection and insecticidal activity of PermaNet 3.0 and PermaNet<sup>® </sup>2.0 were excellent (>80%) in the "pyrethroid-tolerant" area of Malanville. In the pyrethroid-resistance areas of Pitoa (metabolic resistance) and Vallée du Kou (presence of the L1014F <it>kdr </it>mutation), PermaNet<sup>® </sup>3.0 showed equal or better performances than PermaNet<sup>® </sup>2.0. It should be noted however that the deltamethrin content on PermaNet<sup>® </sup>3.0 was up to twice higher than that of PermaNet<sup>® </sup>2.0. Significant reduction of efficacy of both LLIN was noted after 20 washes although PermaNet<sup>® </sup>3.0 still fulfilled the WHO requirement for LLIN.</p> <p>Conclusion</p> <p>The use of combination nets for malaria control offers promising prospects. However, further investigations are needed to demonstrate the benefits of using PermaNet<sup>® </sup>3.0 for the control of pyrethroid resistant mosquito populations in Africa.</p>http://www.malariajournal.com/content/9/1/113 |
| spellingShingle | Pigeon Olivier Nwane Philippe Etang Josiane Dabiré Roch K Chabi Joseph Corbel Vincent Akogbeto Martin Hougard Jean-Marc Field efficacy of a new mosaic long-lasting mosquito net (PermaNet<sup>® </sup>3.0) against pyrethroid-resistant malaria vectors: a multi centre study in Western and Central Africa Malaria Journal |
| title | Field efficacy of a new mosaic long-lasting mosquito net (PermaNet<sup>® </sup>3.0) against pyrethroid-resistant malaria vectors: a multi centre study in Western and Central Africa |
| title_full | Field efficacy of a new mosaic long-lasting mosquito net (PermaNet<sup>® </sup>3.0) against pyrethroid-resistant malaria vectors: a multi centre study in Western and Central Africa |
| title_fullStr | Field efficacy of a new mosaic long-lasting mosquito net (PermaNet<sup>® </sup>3.0) against pyrethroid-resistant malaria vectors: a multi centre study in Western and Central Africa |
| title_full_unstemmed | Field efficacy of a new mosaic long-lasting mosquito net (PermaNet<sup>® </sup>3.0) against pyrethroid-resistant malaria vectors: a multi centre study in Western and Central Africa |
| title_short | Field efficacy of a new mosaic long-lasting mosquito net (PermaNet<sup>® </sup>3.0) against pyrethroid-resistant malaria vectors: a multi centre study in Western and Central Africa |
| title_sort | field efficacy of a new mosaic long lasting mosquito net permanet sup r sup 3 0 against pyrethroid resistant malaria vectors a multi centre study in western and central africa |
| url | http://www.malariajournal.com/content/9/1/113 |
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