The Phenomenon of Drug Emulsion Carriers Compaction during Their Movement in Microstructures

The greatest challenges of modern pharmacology are the design of drugs with the highest possible efficacy of an active substance and with the lowest possible invasiveness for the whole organism. A good solution features the application of a bioactive substance in different carriers. The effectivenes...

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Main Authors: Mariola M. Błaszczyk, Jerzy Sęk, Łukasz Przybysz
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Pharmaceutics
Subjects:
Online Access:https://www.mdpi.com/1999-4923/14/3/585
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author Mariola M. Błaszczyk
Jerzy Sęk
Łukasz Przybysz
author_facet Mariola M. Błaszczyk
Jerzy Sęk
Łukasz Przybysz
author_sort Mariola M. Błaszczyk
collection DOAJ
description The greatest challenges of modern pharmacology are the design of drugs with the highest possible efficacy of an active substance and with the lowest possible invasiveness for the whole organism. A good solution features the application of a bioactive substance in different carriers. The effectiveness of such preparations is determined not only by the properties of the drug, but primarily by the dynamics of carrier movement in the body. This is the reason why studies on the dispersed systems transport in micro- and nanostructures are becoming important. This paper presents a study of emulsion systems transport in microcapillaries. A dispersed phase thickening effect was observed during the process, which resulted in a concentration increase of the flowing emulsion, in some cases up to 10 times. This phenomenon directly influences transport dynamics of such substances in microstructures and should be taken into account when designing drug parameters (concentration, release time, and action range). The effect was investigated for three different emulsions concentrations and presented quantitatively. The scales of this phenomenon occurrence at different flow conditions were investigated, and their magnitudes were modelled and described. This allows the prediction of the flow resistance in the movement of given dispersion systems, as a function of the flow rate, the emulsion parameters, and the microchannel size.
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spelling doaj.art-c8b1a5c488a74fad96a1367da0256c6b2023-11-30T21:57:01ZengMDPI AGPharmaceutics1999-49232022-03-0114358510.3390/pharmaceutics14030585The Phenomenon of Drug Emulsion Carriers Compaction during Their Movement in MicrostructuresMariola M. Błaszczyk0Jerzy Sęk1Łukasz Przybysz2Department of Chemical Engineering, Faculty of Process and Environmental Engineering, Lodz University of Technology, 213 Wolczanska St., 90-924 Lodz, PolandDepartment of Chemical Engineering, Faculty of Process and Environmental Engineering, Lodz University of Technology, 213 Wolczanska St., 90-924 Lodz, PolandDepartment of Chemical Engineering, Faculty of Process and Environmental Engineering, Lodz University of Technology, 213 Wolczanska St., 90-924 Lodz, PolandThe greatest challenges of modern pharmacology are the design of drugs with the highest possible efficacy of an active substance and with the lowest possible invasiveness for the whole organism. A good solution features the application of a bioactive substance in different carriers. The effectiveness of such preparations is determined not only by the properties of the drug, but primarily by the dynamics of carrier movement in the body. This is the reason why studies on the dispersed systems transport in micro- and nanostructures are becoming important. This paper presents a study of emulsion systems transport in microcapillaries. A dispersed phase thickening effect was observed during the process, which resulted in a concentration increase of the flowing emulsion, in some cases up to 10 times. This phenomenon directly influences transport dynamics of such substances in microstructures and should be taken into account when designing drug parameters (concentration, release time, and action range). The effect was investigated for three different emulsions concentrations and presented quantitatively. The scales of this phenomenon occurrence at different flow conditions were investigated, and their magnitudes were modelled and described. This allows the prediction of the flow resistance in the movement of given dispersion systems, as a function of the flow rate, the emulsion parameters, and the microchannel size.https://www.mdpi.com/1999-4923/14/3/585emulsion carriersdrug deliverymicrofluidicscapillariesemulsion flow
spellingShingle Mariola M. Błaszczyk
Jerzy Sęk
Łukasz Przybysz
The Phenomenon of Drug Emulsion Carriers Compaction during Their Movement in Microstructures
Pharmaceutics
emulsion carriers
drug delivery
microfluidics
capillaries
emulsion flow
title The Phenomenon of Drug Emulsion Carriers Compaction during Their Movement in Microstructures
title_full The Phenomenon of Drug Emulsion Carriers Compaction during Their Movement in Microstructures
title_fullStr The Phenomenon of Drug Emulsion Carriers Compaction during Their Movement in Microstructures
title_full_unstemmed The Phenomenon of Drug Emulsion Carriers Compaction during Their Movement in Microstructures
title_short The Phenomenon of Drug Emulsion Carriers Compaction during Their Movement in Microstructures
title_sort phenomenon of drug emulsion carriers compaction during their movement in microstructures
topic emulsion carriers
drug delivery
microfluidics
capillaries
emulsion flow
url https://www.mdpi.com/1999-4923/14/3/585
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