Poly(ADP-Ribose) Polymerase-1 Lacking Enzymatic Activity Is Not Compatible with Mouse Development

Poly(ADP-Ribose) Polymerase-1 Lacking Enzymatic Activity Is Not Compatible with Mouse Development

Poly(ADP-ribose) polymerase-1 (PARP1) binds DNA lesions to catalyse poly(ADP-ribosyl)ation (PARylation) using NAD+ as a substrate. PARP1 plays multiple roles in cellular activities, including DNA repair, transcription, cell death, and chromatin remodelling. However, whether these functions are gover...

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Bibliographic Details
Main Authors: Tatiana Kamaletdinova, Wen Zong, Pavel Urbánek, Sijia Wang, Mara Sannai, Paulius Grigaravičius, Wenli Sun, Zahra Fanaei-Kahrani, Aswin Mangerich, Michael O. Hottiger, Tangliang Li, Zhao-Qi Wang
Format: Article
Language:English
Published: MDPI AG 2023-08-01
Series:Cells
Subjects:
PARP1
PARP2
catalytic activity
development
ES cell differentiation
genotoxic stress
Online Access:https://www.mdpi.com/2073-4409/12/16/2078

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