The pre-conception maternal exposure to Sofosbuvir affects the mitochondrial biogenesis in prenatal fetal tissues: Experimental study on rats

The pre-conception maternal exposure to Sofosbuvir affects the mitochondrial biogenesis in prenatal fetal tissues: Experimental study on rats

Abstract Background  Hepatitis C virus (HCV) infection is a global public health problem and Egypt has the highest HCV prevalence worldwide. Hence, global efforts target to eliminate HCV by 2030. Sofosbuvir is a nucleotide analogue inhibitor of HCV polymerase essential for viral replication. Animal...

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Bibliographic Details
Main Authors: Shimaa A. Mahmoud, Maryam M. Abdel-Aziz, Rana H. M. Khafaga, Hala A. Hafez, Maher A. Kamel, Sara A. Shaker
Format: Article
Language:English
Published: BMC 2023-06-01
Series:Molecular Medicine
Subjects:
Hepatitis C virus
Mitochondrial biogenesis
Sofosbuvir
Pregnancy outcome
Online Access:https://doi.org/10.1186/s10020-023-00666-x

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