The Causal Role of Lipoxidative Damage in Mitochondrial Bioenergetic Dysfunction Linked to Alzheimer’s Disease Pathology

The Causal Role of Lipoxidative Damage in Mitochondrial Bioenergetic Dysfunction Linked to Alzheimer’s Disease Pathology

Current shreds of evidence point to the entorhinal cortex (EC) as the origin of the Alzheimer’s disease (AD) pathology in the cerebrum. Compared with other cortical areas, the neurons from this brain region possess an inherent selective vulnerability derived from particular oxidative stress conditio...

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Bibliographic Details
Main Authors: Mariona Jové, Natàlia Mota-Martorell, Pascual Torres, Victoria Ayala, Manuel Portero-Otin, Isidro Ferrer, Reinald Pamplona
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Life
Subjects:
aging
ATP synthase
energy metabolism
entorhinal cortex
lipoxidation-derived damage
mitochondrial dysfunction
Online Access:https://www.mdpi.com/2075-1729/11/5/388

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