Antimigratory Activity of Royal Jelly on HCT-116 Colorectal Cancer Cells
Royal jelly (RJ) is a natural product, consumed as a functional food and in the form of a food supplement with multiple biological potentials. Apitherapy presents a complementary medical approach using bee products in the treatment of diseases, including cancer. Cancer metastasis implies the acquisi...
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| Format: | Article |
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MDPI AG
2022-09-01
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| Series: | Biology and Life Sciences Forum |
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| Online Access: | https://www.mdpi.com/2673-9976/18/1/60 |
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| author | Milena M. Jovanović Katarina Virijević Jelena Pavić Dejan Arsenijević Katarina Pecić Nikolina Kastratović Marko Živanović Dragana Šeklić |
| author_facet | Milena M. Jovanović Katarina Virijević Jelena Pavić Dejan Arsenijević Katarina Pecić Nikolina Kastratović Marko Živanović Dragana Šeklić |
| author_sort | Milena M. Jovanović |
| collection | DOAJ |
| description | Royal jelly (RJ) is a natural product, consumed as a functional food and in the form of a food supplement with multiple biological potentials. Apitherapy presents a complementary medical approach using bee products in the treatment of diseases, including cancer. Cancer metastasis implies the acquisition of migratory potential of cancer cells, and RJ already showed remarkable antimetastatic effects. We aimed to investigate the effects of RJ on the migration of colorectal cancer cells and key proteins involved in this process, E- and N-cadherin. Experiments were done 24 h after treatment with two selected concentrations. RJ suppressed the migratory potential of colorectal cancer cell line HCT-116, and enhanced the expression of anti-migratory protein, E-cadherin, while significantly inhibiting the promigratory marker, N-cadherin. |
| first_indexed | 2024-03-11T06:51:54Z |
| format | Article |
| id | doaj.art-c8b97bf8290744f69353f1362f46a39f |
| institution | Directory Open Access Journal |
| issn | 2673-9976 |
| language | English |
| last_indexed | 2024-03-11T06:51:54Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biology and Life Sciences Forum |
| spelling | doaj.art-c8b97bf8290744f69353f1362f46a39f2023-11-17T09:56:48ZengMDPI AGBiology and Life Sciences Forum2673-99762022-09-011816010.3390/Foods2022-12951Antimigratory Activity of Royal Jelly on HCT-116 Colorectal Cancer CellsMilena M. Jovanović0Katarina Virijević1Jelena Pavić2Dejan Arsenijević3Katarina Pecić4Nikolina Kastratović5Marko Živanović6Dragana Šeklić7Department of Biology and Ecology, Faculty of Science, University of Kragujevac, 34000 Kragujevac, SerbiaDepartment of Natural Sciences, Institute for Information Technologies, University of Kragujevac, 34000 Kragujevac, SerbiaDepartment of Natural Sciences, Institute for Information Technologies, University of Kragujevac, 34000 Kragujevac, SerbiaDepartment of Biology and Ecology, Faculty of Science, University of Kragujevac, 34000 Kragujevac, SerbiaDepartment of Technical and Technological Sciences, Institute for Information Technologies, University of Kragujevac, 34000 Kragujevac, SerbiaFaculty of Medical Sciences, University of Kragujevac, 34000 Kragujevac, SerbiaDepartment of Natural Sciences, Institute for Information Technologies, University of Kragujevac, 34000 Kragujevac, SerbiaDepartment of Natural Sciences, Institute for Information Technologies, University of Kragujevac, 34000 Kragujevac, SerbiaRoyal jelly (RJ) is a natural product, consumed as a functional food and in the form of a food supplement with multiple biological potentials. Apitherapy presents a complementary medical approach using bee products in the treatment of diseases, including cancer. Cancer metastasis implies the acquisition of migratory potential of cancer cells, and RJ already showed remarkable antimetastatic effects. We aimed to investigate the effects of RJ on the migration of colorectal cancer cells and key proteins involved in this process, E- and N-cadherin. Experiments were done 24 h after treatment with two selected concentrations. RJ suppressed the migratory potential of colorectal cancer cell line HCT-116, and enhanced the expression of anti-migratory protein, E-cadherin, while significantly inhibiting the promigratory marker, N-cadherin.https://www.mdpi.com/2673-9976/18/1/60N-cadherinTranswell assayapitherapymigrationnatural product |
| spellingShingle | Milena M. Jovanović Katarina Virijević Jelena Pavić Dejan Arsenijević Katarina Pecić Nikolina Kastratović Marko Živanović Dragana Šeklić Antimigratory Activity of Royal Jelly on HCT-116 Colorectal Cancer Cells Biology and Life Sciences Forum N-cadherin Transwell assay apitherapy migration natural product |
| title | Antimigratory Activity of Royal Jelly on HCT-116 Colorectal Cancer Cells |
| title_full | Antimigratory Activity of Royal Jelly on HCT-116 Colorectal Cancer Cells |
| title_fullStr | Antimigratory Activity of Royal Jelly on HCT-116 Colorectal Cancer Cells |
| title_full_unstemmed | Antimigratory Activity of Royal Jelly on HCT-116 Colorectal Cancer Cells |
| title_short | Antimigratory Activity of Royal Jelly on HCT-116 Colorectal Cancer Cells |
| title_sort | antimigratory activity of royal jelly on hct 116 colorectal cancer cells |
| topic | N-cadherin Transwell assay apitherapy migration natural product |
| url | https://www.mdpi.com/2673-9976/18/1/60 |
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