FUS-ERG induces late-onset azacitidine resistance in acute myeloid leukaemia cells

FUS-ERG induces late-onset azacitidine resistance in acute myeloid leukaemia cells

Abstract FUS-ERG is a chimeric gene with a poor prognosis, found in myelodysplastic syndromes (MDS) and acute myeloid leukaemia (AML). It remains unclear whether DNA hypomethylating agents, including azacitidine (Aza), are effective in FUS-ERG-harbouring AML and how FUS-ERG induces chemoresistance....

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Main Authors: Ai Asai-Nishishita, Masahiro Kawahara, Goichi Tatsumi, Masaki Iwasa, Aya Fujishiro, Rie Nishimura, Hitoshi Minamiguchi, Katsuyuki Kito, Makoto Murata, Akira Andoh
Format: Article
Language:English
Published: Nature Portfolio 2023-09-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-41230-1

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