Constituents of the Fruits of Citrus medica L. var. sarcodactylis and the Effect of 6,7-Dimethoxy-coumarin on Superoxide Anion Formation and Elastase Release
Investigation of the chemical constituents from the fruits of Citrus medica L. var. sarcodactylis Swingle has led to the characterization of a new sesquiterpene 1 along with thirty-two known compounds. The structure of 1 was established on the basis of 2D NMR spectroscopic and mass spectrometric ana...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2017-09-01
|
| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/22/9/1454 |
| _version_ | 1818133254333530112 |
|---|---|
| author | Yu-Yi Chan Tsong-Long Hwang Ping-Chung Kuo Hsin-Yi Hung Tian-Shung Wu |
| author_facet | Yu-Yi Chan Tsong-Long Hwang Ping-Chung Kuo Hsin-Yi Hung Tian-Shung Wu |
| author_sort | Yu-Yi Chan |
| collection | DOAJ |
| description | Investigation of the chemical constituents from the fruits of Citrus medica L. var. sarcodactylis Swingle has led to the characterization of a new sesquiterpene 1 along with thirty-two known compounds. The structure of 1 was established on the basis of 2D NMR spectroscopic and mass spectrometric analyses, and the known compounds were identified by comparison of their physical and spectroscopic data with those reported in the literature. In addition, most of the isolated compounds were evaluated for the activity assayed by the in vitro inhibition of superoxide anion generation and elastase release by human neutrophils. The results showed that only 6,7-dimethoxycoumarin (5) exhibited significant inhibition of superoxide anion generation, with IC50 value of 3.8 ± 1.4 μM. |
| first_indexed | 2024-12-11T08:49:48Z |
| format | Article |
| id | doaj.art-c8bb85fc19a3453481b27f1163791584 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-11T08:49:48Z |
| publishDate | 2017-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-c8bb85fc19a3453481b27f11637915842022-12-22T01:14:03ZengMDPI AGMolecules1420-30492017-09-01229145410.3390/molecules22091454molecules22091454Constituents of the Fruits of Citrus medica L. var. sarcodactylis and the Effect of 6,7-Dimethoxy-coumarin on Superoxide Anion Formation and Elastase ReleaseYu-Yi Chan0Tsong-Long Hwang1Ping-Chung Kuo2Hsin-Yi Hung3Tian-Shung Wu4Department of Biotechnology, Southern Taiwan University of Science and Technology, Tainan 71005, TaiwanGraduate Institute of Natural Products, College of Medicine, Chang Gung University, Taoyuan 333, TaiwanSchool of Pharmacy, College of Medicine, National Cheng Kung University, Tainan 701, TaiwanSchool of Pharmacy, College of Medicine, National Cheng Kung University, Tainan 701, TaiwanSchool of Pharmacy, College of Medicine, National Cheng Kung University, Tainan 701, TaiwanInvestigation of the chemical constituents from the fruits of Citrus medica L. var. sarcodactylis Swingle has led to the characterization of a new sesquiterpene 1 along with thirty-two known compounds. The structure of 1 was established on the basis of 2D NMR spectroscopic and mass spectrometric analyses, and the known compounds were identified by comparison of their physical and spectroscopic data with those reported in the literature. In addition, most of the isolated compounds were evaluated for the activity assayed by the in vitro inhibition of superoxide anion generation and elastase release by human neutrophils. The results showed that only 6,7-dimethoxycoumarin (5) exhibited significant inhibition of superoxide anion generation, with IC50 value of 3.8 ± 1.4 μM.https://www.mdpi.com/1420-3049/22/9/1454Citrus medica L. var. sarcodactylis SwingleRutaceaesesquiterpenecitrumedin-Csuperoxide anion formationelastase release |
| spellingShingle | Yu-Yi Chan Tsong-Long Hwang Ping-Chung Kuo Hsin-Yi Hung Tian-Shung Wu Constituents of the Fruits of Citrus medica L. var. sarcodactylis and the Effect of 6,7-Dimethoxy-coumarin on Superoxide Anion Formation and Elastase Release Molecules Citrus medica L. var. sarcodactylis Swingle Rutaceae sesquiterpene citrumedin-C superoxide anion formation elastase release |
| title | Constituents of the Fruits of Citrus medica L. var. sarcodactylis and the Effect of 6,7-Dimethoxy-coumarin on Superoxide Anion Formation and Elastase Release |
| title_full | Constituents of the Fruits of Citrus medica L. var. sarcodactylis and the Effect of 6,7-Dimethoxy-coumarin on Superoxide Anion Formation and Elastase Release |
| title_fullStr | Constituents of the Fruits of Citrus medica L. var. sarcodactylis and the Effect of 6,7-Dimethoxy-coumarin on Superoxide Anion Formation and Elastase Release |
| title_full_unstemmed | Constituents of the Fruits of Citrus medica L. var. sarcodactylis and the Effect of 6,7-Dimethoxy-coumarin on Superoxide Anion Formation and Elastase Release |
| title_short | Constituents of the Fruits of Citrus medica L. var. sarcodactylis and the Effect of 6,7-Dimethoxy-coumarin on Superoxide Anion Formation and Elastase Release |
| title_sort | constituents of the fruits of citrus medica l var sarcodactylis and the effect of 6 7 dimethoxy coumarin on superoxide anion formation and elastase release |
| topic | Citrus medica L. var. sarcodactylis Swingle Rutaceae sesquiterpene citrumedin-C superoxide anion formation elastase release |
| url | https://www.mdpi.com/1420-3049/22/9/1454 |
| work_keys_str_mv | AT yuyichan constituentsofthefruitsofcitrusmedicalvarsarcodactylisandtheeffectof67dimethoxycoumarinonsuperoxideanionformationandelastaserelease AT tsonglonghwang constituentsofthefruitsofcitrusmedicalvarsarcodactylisandtheeffectof67dimethoxycoumarinonsuperoxideanionformationandelastaserelease AT pingchungkuo constituentsofthefruitsofcitrusmedicalvarsarcodactylisandtheeffectof67dimethoxycoumarinonsuperoxideanionformationandelastaserelease AT hsinyihung constituentsofthefruitsofcitrusmedicalvarsarcodactylisandtheeffectof67dimethoxycoumarinonsuperoxideanionformationandelastaserelease AT tianshungwu constituentsofthefruitsofcitrusmedicalvarsarcodactylisandtheeffectof67dimethoxycoumarinonsuperoxideanionformationandelastaserelease |