Multimodal magnetic resonance imaging on brain structure and function changes in vascular cognitive impairment without dementia
Vascular cognitive impairment not dementia (VCIND) is one of the three subtypes of vascular cognitive impairment (VCI), with cognitive dysfunction and symptoms ranging between normal cognitive function and vascular dementia. The specific mechanisms underlying VCIND are still not fully understood, an...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-11-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2023.1278390/full |
| _version_ | 1797626648065998848 |
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| author | Qinhong Zhang Qinhong Zhang Xiao Liu Shenglan Gao Shiyan Yan Ang Li Zeyi Wei Shengwang Han Yu Hou Xiaoling Li Danna Cao Jinhuan Yue Jinhuan Yue |
| author_facet | Qinhong Zhang Qinhong Zhang Xiao Liu Shenglan Gao Shiyan Yan Ang Li Zeyi Wei Shengwang Han Yu Hou Xiaoling Li Danna Cao Jinhuan Yue Jinhuan Yue |
| author_sort | Qinhong Zhang |
| collection | DOAJ |
| description | Vascular cognitive impairment not dementia (VCIND) is one of the three subtypes of vascular cognitive impairment (VCI), with cognitive dysfunction and symptoms ranging between normal cognitive function and vascular dementia. The specific mechanisms underlying VCIND are still not fully understood, and there is a lack of specific diagnostic markers in clinical practice. With the rapid development of magnetic resonance imaging (MRI) technology, structural MRI (sMRI) and functional MRI (fMRI) have become effective methods for exploring the neurobiological mechanisms of VCIND and have made continuous progress. This article provides a comprehensive overview of the research progress in VCIND using multimodal MRI, including sMRI, diffusion tensor imaging, resting-state fMRI, and magnetic resonance spectroscopy. By integrating findings from these multiple modalities, this study presents a novel perspective on the neuropathological mechanisms underlying VCIND. It not only highlights the importance of multimodal MRI in unraveling the complex nature of VCIND but also lays the foundation for future research examining the relationship between brain structure, function, and cognitive impairment in VCIND. These new perspectives and strategies ultimately hold the potential to contribute to the development of more effective diagnostic tools and therapeutic interventions for VCIND. |
| first_indexed | 2024-03-11T10:13:10Z |
| format | Article |
| id | doaj.art-c8bcb60045064d09bf20a85d5bdc3663 |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-03-11T10:13:10Z |
| publishDate | 2023-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-c8bcb60045064d09bf20a85d5bdc36632023-11-16T13:13:31ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652023-11-011510.3389/fnagi.2023.12783901278390Multimodal magnetic resonance imaging on brain structure and function changes in vascular cognitive impairment without dementiaQinhong Zhang0Qinhong Zhang1Xiao Liu2Shenglan Gao3Shiyan Yan4Ang Li5Zeyi Wei6Shengwang Han7Yu Hou8Xiaoling Li9Danna Cao10Jinhuan Yue11Jinhuan Yue12Shenzhen Frontiers in Chinese Medicine Research Co., Ltd., Shenzhen, ChinaDepartment of Acupuncture and Moxibustion, Heilongjiang University of Chinese Medicine, Harbin, ChinaDepartment of Pediatrics, First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, ChinaGraduate School of Heilongjiang University of Chinese Medicine, Harbin, ChinaSchool of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine, Beijing, ChinaServier (Beijing) Pharmaceutical Research and Development Co., Ltd., Beijing, ChinaGraduate School of Heilongjiang University of Chinese Medicine, Harbin, ChinaThird Ward of Rehabilitation Department, Second Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, ChinaDepartment of Gynecology, Harbin Traditional Chinese Medicine Hospital, Harbin, ChinaDivision of CT and MRI, First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, ChinaDivision of CT and MRI, First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, ChinaShenzhen Frontiers in Chinese Medicine Research Co., Ltd., Shenzhen, China0Department of Acupuncture and Moxibustion, Vitality University, Hayward, CA, United StatesVascular cognitive impairment not dementia (VCIND) is one of the three subtypes of vascular cognitive impairment (VCI), with cognitive dysfunction and symptoms ranging between normal cognitive function and vascular dementia. The specific mechanisms underlying VCIND are still not fully understood, and there is a lack of specific diagnostic markers in clinical practice. With the rapid development of magnetic resonance imaging (MRI) technology, structural MRI (sMRI) and functional MRI (fMRI) have become effective methods for exploring the neurobiological mechanisms of VCIND and have made continuous progress. This article provides a comprehensive overview of the research progress in VCIND using multimodal MRI, including sMRI, diffusion tensor imaging, resting-state fMRI, and magnetic resonance spectroscopy. By integrating findings from these multiple modalities, this study presents a novel perspective on the neuropathological mechanisms underlying VCIND. It not only highlights the importance of multimodal MRI in unraveling the complex nature of VCIND but also lays the foundation for future research examining the relationship between brain structure, function, and cognitive impairment in VCIND. These new perspectives and strategies ultimately hold the potential to contribute to the development of more effective diagnostic tools and therapeutic interventions for VCIND.https://www.frontiersin.org/articles/10.3389/fnagi.2023.1278390/fullvascular cognitive impairment not dementiamultimodalmagnetic resonance imagingbrain structurebrain function |
| spellingShingle | Qinhong Zhang Qinhong Zhang Xiao Liu Shenglan Gao Shiyan Yan Ang Li Zeyi Wei Shengwang Han Yu Hou Xiaoling Li Danna Cao Jinhuan Yue Jinhuan Yue Multimodal magnetic resonance imaging on brain structure and function changes in vascular cognitive impairment without dementia Frontiers in Aging Neuroscience vascular cognitive impairment not dementia multimodal magnetic resonance imaging brain structure brain function |
| title | Multimodal magnetic resonance imaging on brain structure and function changes in vascular cognitive impairment without dementia |
| title_full | Multimodal magnetic resonance imaging on brain structure and function changes in vascular cognitive impairment without dementia |
| title_fullStr | Multimodal magnetic resonance imaging on brain structure and function changes in vascular cognitive impairment without dementia |
| title_full_unstemmed | Multimodal magnetic resonance imaging on brain structure and function changes in vascular cognitive impairment without dementia |
| title_short | Multimodal magnetic resonance imaging on brain structure and function changes in vascular cognitive impairment without dementia |
| title_sort | multimodal magnetic resonance imaging on brain structure and function changes in vascular cognitive impairment without dementia |
| topic | vascular cognitive impairment not dementia multimodal magnetic resonance imaging brain structure brain function |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2023.1278390/full |
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