Brain activation during an emotional task in participants with PTSD and borderline and/or cluster C personality disorders
Introduction: Although comorbidity of post-traumatic stress disorder (PTSD) with borderline personality disorder (BPD) and/or cluster C personality disorders (CPD) is common, neural correlates of this comorbidity are unknown. Methods: We acquired functional MRI scans during an emotional face task in...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-01-01
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| Series: | NeuroImage: Clinical |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213158223002450 |
| _version_ | 1797263628742688768 |
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| author | Inga Aarts Chris Vriend Odile A. van den Heuvel Kathleen Thomaes |
| author_facet | Inga Aarts Chris Vriend Odile A. van den Heuvel Kathleen Thomaes |
| author_sort | Inga Aarts |
| collection | DOAJ |
| description | Introduction: Although comorbidity of post-traumatic stress disorder (PTSD) with borderline personality disorder (BPD) and/or cluster C personality disorders (CPD) is common, neural correlates of this comorbidity are unknown. Methods: We acquired functional MRI scans during an emotional face task in participants with PTSD + CPD (n = 34), PTSD + BPD (n = 24), PTSD + BPD + CPD (n = 18) and controls (n = 30). We used ANCOVAs and Bayesian analyses on specific ROIs in a fearful vs. scrambled faces contrast. We also investigated associations with clinical measures. Results: There were no robust differences in brain activation between the groups with ANCOVAs. Transdiagnostically, we found a negative association between severity of dissociation and right insula and right dmPFC activation, and emotion regulation problems with right dmPFC activation. Bayesian analyses showed credible evidence for higher activation in all ROIs in the PTSD + BPD + CPD group compared to PTSD + BPD and PTSD + CPD. Discussion: Our Bayesian and correlation analyses support new dimensional conceptualizations of personality disorders. |
| first_indexed | 2024-03-08T21:12:44Z |
| format | Article |
| id | doaj.art-c8bdb559b96142758318ab29fbae42c9 |
| institution | Directory Open Access Journal |
| issn | 2213-1582 |
| language | English |
| last_indexed | 2024-04-25T00:16:02Z |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage: Clinical |
| spelling | doaj.art-c8bdb559b96142758318ab29fbae42c92024-03-13T04:45:33ZengElsevierNeuroImage: Clinical2213-15822024-01-0141103554Brain activation during an emotional task in participants with PTSD and borderline and/or cluster C personality disordersInga Aarts0Chris Vriend1Odile A. van den Heuvel2Kathleen Thomaes3Sinai Centrum, Arkin, Amstelveen, the Netherlands; Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Psychiatry, Department of Anatomy and Neurosciences, Boelelaan 1117, Amsterdam, the Netherlands; Corresponding author at: Sinai Centrum, Arkin, Amstelveen, The Netherlands.Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Psychiatry, Department of Anatomy and Neurosciences, Boelelaan 1117, Amsterdam, the Netherlands; Amsterdam Neuroscience, Compulsivity, Impulsivity & Attention program, Amsterdam, the NetherlandsAmsterdam UMC, Vrije Universiteit Amsterdam, Department of Psychiatry, Department of Anatomy and Neurosciences, Boelelaan 1117, Amsterdam, the Netherlands; Amsterdam Neuroscience, Compulsivity, Impulsivity & Attention program, Amsterdam, the NetherlandsSinai Centrum, Arkin, Amstelveen, the Netherlands; Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Psychiatry, Department of Anatomy and Neurosciences, Boelelaan 1117, Amsterdam, the NetherlandsIntroduction: Although comorbidity of post-traumatic stress disorder (PTSD) with borderline personality disorder (BPD) and/or cluster C personality disorders (CPD) is common, neural correlates of this comorbidity are unknown. Methods: We acquired functional MRI scans during an emotional face task in participants with PTSD + CPD (n = 34), PTSD + BPD (n = 24), PTSD + BPD + CPD (n = 18) and controls (n = 30). We used ANCOVAs and Bayesian analyses on specific ROIs in a fearful vs. scrambled faces contrast. We also investigated associations with clinical measures. Results: There were no robust differences in brain activation between the groups with ANCOVAs. Transdiagnostically, we found a negative association between severity of dissociation and right insula and right dmPFC activation, and emotion regulation problems with right dmPFC activation. Bayesian analyses showed credible evidence for higher activation in all ROIs in the PTSD + BPD + CPD group compared to PTSD + BPD and PTSD + CPD. Discussion: Our Bayesian and correlation analyses support new dimensional conceptualizations of personality disorders.http://www.sciencedirect.com/science/article/pii/S2213158223002450PSTDBorderline Personality DisorderCluster c personality disorderEmotional face taskAvoidant personality disorderfMRI |
| spellingShingle | Inga Aarts Chris Vriend Odile A. van den Heuvel Kathleen Thomaes Brain activation during an emotional task in participants with PTSD and borderline and/or cluster C personality disorders NeuroImage: Clinical PSTD Borderline Personality Disorder Cluster c personality disorder Emotional face task Avoidant personality disorder fMRI |
| title | Brain activation during an emotional task in participants with PTSD and borderline and/or cluster C personality disorders |
| title_full | Brain activation during an emotional task in participants with PTSD and borderline and/or cluster C personality disorders |
| title_fullStr | Brain activation during an emotional task in participants with PTSD and borderline and/or cluster C personality disorders |
| title_full_unstemmed | Brain activation during an emotional task in participants with PTSD and borderline and/or cluster C personality disorders |
| title_short | Brain activation during an emotional task in participants with PTSD and borderline and/or cluster C personality disorders |
| title_sort | brain activation during an emotional task in participants with ptsd and borderline and or cluster c personality disorders |
| topic | PSTD Borderline Personality Disorder Cluster c personality disorder Emotional face task Avoidant personality disorder fMRI |
| url | http://www.sciencedirect.com/science/article/pii/S2213158223002450 |
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