Metabolic activity of intestinal microflora in patients with bronchial asthma
The gut microbiota plays the important role to support the immunological tolerance. To study a metabolic activity of the intestinal microflora the 44 patients suffering from bronchial asthma and 17 healthy volunteers were tested. The short-chain fatty acids (SCFA) spectrum was determined using the m...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2019-02-01
|
| Series: | Clinics and Practice |
| Subjects: | |
| Online Access: | https://www.clinicsandpractice.org/index.php/cp/article/view/1126 |
| _version_ | 1828136901800886272 |
|---|---|
| author | Vladimir Ivashkin Oxana Zolnikova Nino Potskherashvili Alexander Trukhmanov Natalia Kokina Alla Sedova Elena Bueverova |
| author_facet | Vladimir Ivashkin Oxana Zolnikova Nino Potskherashvili Alexander Trukhmanov Natalia Kokina Alla Sedova Elena Bueverova |
| author_sort | Vladimir Ivashkin |
| collection | DOAJ |
| description | The gut microbiota plays the important role to support the immunological tolerance. To study a metabolic activity of the intestinal microflora the 44 patients suffering from bronchial asthma and 17 healthy volunteers were tested. The short-chain fatty acids (SCFA) spectrum was determined using the method of gas-liquid chromatographic analysis. We have detected a significant decrease the total content of the fatty acids in the feces (P<0.001), the absolute concentrations of the individual acids (acetate, propionate, butyrate; P<0.001) and the total content of isoacids (P<0.001) for all of the patients with bronchial asthma in the study, regardless of the phenotype. The anaerobic type of the SCFA spectrum was detected for the majority (83%) of the patients tested. The aerobic type of the SCFA metabolic profile was detected for another part (17%) of the patients tested. Being detected the parameters change could play the principal role as for the bronchial asthma course as to support the organism sensibilisation. |
| first_indexed | 2024-04-11T18:11:12Z |
| format | Article |
| id | doaj.art-c8bf5c5e09004d44b8285e7ae132078c |
| institution | Directory Open Access Journal |
| issn | 2039-7275 2039-7283 |
| language | English |
| last_indexed | 2024-04-11T18:11:12Z |
| publishDate | 2019-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Clinics and Practice |
| spelling | doaj.art-c8bf5c5e09004d44b8285e7ae132078c2022-12-22T04:10:07ZengMDPI AGClinics and Practice2039-72752039-72832019-02-019110.4081/cp.2019.1126Metabolic activity of intestinal microflora in patients with bronchial asthmaVladimir Ivashkin0Oxana Zolnikova1Nino Potskherashvili2Alexander Trukhmanov3Natalia Kokina4Alla Sedova5Elena Bueverova6Chair of Internal Diseases Propedeutics, I.M. Sechenov First Moscow State Medical University, MoscowChair of Internal Diseases Propedeutics, I.M. Sechenov First Moscow State Medical University, MoscowVasilenko Clinic of Internal Disease Propedeutics, Gastroenterology, and Hepatology, I.M. Sechenov First Moscow State Medical University, MoscowChair of Internal Diseases Propedeutics, I.M. Sechenov First Moscow State Medical University, MoscowVasilenko Clinic of Internal Disease Propedeutics, Gastroenterology, and Hepatology, I.M. Sechenov First Moscow State Medical University, MoscowChair of Internal Diseases Propedeutics, I.M. Sechenov First Moscow State Medical University, MoscowChair of Internal Diseases Propedeutics, I.M. Sechenov First Moscow State Medical University, MoscowThe gut microbiota plays the important role to support the immunological tolerance. To study a metabolic activity of the intestinal microflora the 44 patients suffering from bronchial asthma and 17 healthy volunteers were tested. The short-chain fatty acids (SCFA) spectrum was determined using the method of gas-liquid chromatographic analysis. We have detected a significant decrease the total content of the fatty acids in the feces (P<0.001), the absolute concentrations of the individual acids (acetate, propionate, butyrate; P<0.001) and the total content of isoacids (P<0.001) for all of the patients with bronchial asthma in the study, regardless of the phenotype. The anaerobic type of the SCFA spectrum was detected for the majority (83%) of the patients tested. The aerobic type of the SCFA metabolic profile was detected for another part (17%) of the patients tested. Being detected the parameters change could play the principal role as for the bronchial asthma course as to support the organism sensibilisation.https://www.clinicsandpractice.org/index.php/cp/article/view/1126Short-chain fatty acidsGut microbiotaBronchial asthmaImmunomodulation |
| spellingShingle | Vladimir Ivashkin Oxana Zolnikova Nino Potskherashvili Alexander Trukhmanov Natalia Kokina Alla Sedova Elena Bueverova Metabolic activity of intestinal microflora in patients with bronchial asthma Clinics and Practice Short-chain fatty acids Gut microbiota Bronchial asthma Immunomodulation |
| title | Metabolic activity of intestinal microflora in patients with bronchial asthma |
| title_full | Metabolic activity of intestinal microflora in patients with bronchial asthma |
| title_fullStr | Metabolic activity of intestinal microflora in patients with bronchial asthma |
| title_full_unstemmed | Metabolic activity of intestinal microflora in patients with bronchial asthma |
| title_short | Metabolic activity of intestinal microflora in patients with bronchial asthma |
| title_sort | metabolic activity of intestinal microflora in patients with bronchial asthma |
| topic | Short-chain fatty acids Gut microbiota Bronchial asthma Immunomodulation |
| url | https://www.clinicsandpractice.org/index.php/cp/article/view/1126 |
| work_keys_str_mv | AT vladimirivashkin metabolicactivityofintestinalmicroflorainpatientswithbronchialasthma AT oxanazolnikova metabolicactivityofintestinalmicroflorainpatientswithbronchialasthma AT ninopotskherashvili metabolicactivityofintestinalmicroflorainpatientswithbronchialasthma AT alexandertrukhmanov metabolicactivityofintestinalmicroflorainpatientswithbronchialasthma AT nataliakokina metabolicactivityofintestinalmicroflorainpatientswithbronchialasthma AT allasedova metabolicactivityofintestinalmicroflorainpatientswithbronchialasthma AT elenabueverova metabolicactivityofintestinalmicroflorainpatientswithbronchialasthma |