In Humanized Sickle Cell Mice, Imatinib Protects Against Sickle Cell–Related Injury

In Humanized Sickle Cell Mice, Imatinib Protects Against Sickle Cell–Related Injury

Drug repurposing is a valuable strategy for rare diseases. Sickle cell disease (SCD) is a rare hereditary hemolytic anemia accompanied by acute and chronic painful episodes, most often in the context of vaso-occlusive crisis (VOC). Although progress in the knowledge of pathophysiology of SCD have al...

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Bibliographic Details
Main Authors: Enrica Federti, Alessandro Matte, Antonio Recchiuti, Francesca Garello, Alessandra Ghigo, Wassim El Nemer, Enzo Terreno, Angela Amoresano, Domenico Mattoscio, Franco Turrini, Christophe Lebouef, Anne Janin, Antonella Pantaleo, Roberta Russo, Mickael Marin, Iana Iatcencko, Veronica Riccardi, Angela Siciliano, Achille Iolascon, Carlo Brugnara, Lucia De Franceschi
Format: Article
Language:English
Published: Wiley 2023-03-01
Series:HemaSphere
Online Access:http://journals.lww.com/10.1097/HS9.0000000000000848

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