To Establish Bethesda System for Diagnosis of Thyroid Nodules on the Basis of Fnac with Histopathological Correlation
Introduction: In October 2007, “The National Cancer Institute (NCI), Thyroid Fine Needle Aspiration State of the Science Conference” was held in Bethesda, Maryland hosted by the NCI with the intention of formulating internationally acceptable guidelines for reporting of thyroid cytopathology. Th...
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JCDR Research and Publications Private Limited
2015-12-01
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| Series: | Journal of Clinical and Diagnostic Research |
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| Online Access: | https://jcdr.net/articles/PDF/6897/14823_CE[Ra1]_F(AK)_PF1(BMAK)_PFA(AK)_PF2(PAG).pdf |
| _version_ | 1818029969346920448 |
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| author | Sameep Garg Nandini J. Desai Dimple Mehta Mitsu Vaishnav |
| author_facet | Sameep Garg Nandini J. Desai Dimple Mehta Mitsu Vaishnav |
| author_sort | Sameep Garg |
| collection | DOAJ |
| description | Introduction: In October 2007, “The National Cancer Institute
(NCI), Thyroid Fine Needle Aspiration State of the Science
Conference” was held in Bethesda, Maryland hosted by the
NCI with the intention of formulating internationally acceptable
guidelines for reporting of thyroid cytopathology. This was
because, thyroid FNAC have a reporting confusion due to
multiplicity of category terminologies. To overcome this, The
Bethesda System for Reporting Thyroid Cytopathology
(TBSRTC) was introduced for unifying the terminology and
morphologic criteria along with the corresponding risk of
malignancy. The Bethesda system for reporting thyroid
cytopathology represents a major step towards standardization,
reproducibility, improved clinical significance, and greater
predictive value of thyroid fine needle aspirates (FNAs).
Aim: The aim of this study was to elucidate the diagnostic utility
of the Bethesda system in reporting thyroid FNAs and to assess
the effectiveness of FNAC in the evaluation of thyroid nodules
by comparing the results with histopathological evaluation.
Materials and Methods: The present study was carried out
in our institute during the July 2012 to September 2014. In
this study, 100 FNACs done which were classified according
to the Bethesda system and out of them, 60 histopathological
evaluations obtained from this group were evaluated. The
sensitivity, specificity, positive and negative predictive values
were evaluated.
Results: Out of 100 FNACs, 06% were Non-diagnostic, 78%
were Benign, 04% were Atypical follicular lesion of undetermined
significance (AFLUS), 04% were suspicious for Follicular
neoplasm (SFN), 01% were suspicious for Follicular neoplasm
Hurthle cell type, 03% were suspicious for malignancy (SM), and
04% malignant. In 60 cases, data of follow-up histopathologic
examination (HPE) were available. The sensitivity was 88.89%
and specificity was 84.31%. The positive and negative predictive
value were 50% and 97.7%, respectively.
Conclusion: The Bethesda system is very useful for a
standardized system of reporting thyroid cytopathology,
improving communication between cytopathologists and
clinicians, and inter-laboratory agreement, leading to more
consistent management approaches. An additional point which
is in favor of the implementation of this system is that the
classification is directly related to the risk of malignancy in each
category, which in turn, prompts the recommended clinical
management of that category, thus truly embodying the clinicopathological correlation in its true spirit. The correlation of FNAC
with histopathology is necessary before starting treatment. |
| first_indexed | 2024-12-10T05:28:08Z |
| format | Article |
| id | doaj.art-c8c12dd1f25c4198b591f6134caf20b7 |
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| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-12-10T05:28:08Z |
| publishDate | 2015-12-01 |
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| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-c8c12dd1f25c4198b591f6134caf20b72022-12-22T02:00:38ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2015-12-01912EC17EC2110.7860/JCDR/2015/14823.6897To Establish Bethesda System for Diagnosis of Thyroid Nodules on the Basis of Fnac with Histopathological CorrelationSameep Garg0Nandini J. Desai1Dimple Mehta2Mitsu Vaishnav3Assistant Professor, Department of Pathology, Gujarat Adani Institude of Medical Science, Bhuj, Gujarat, India.Professor, Department of Pathology, Shri M.P. Shah Medical College, Jamnagar, Gujarat, India.Assistant Professor, Department of Pathology, Shri M.P. Shah Medical College, Jamnagar, Gujarat, India.Assistant Professor, Department of Pathology, Gujarat Adani Institude of Medical Science, Bhuj, Gujarat, India.Introduction: In October 2007, “The National Cancer Institute (NCI), Thyroid Fine Needle Aspiration State of the Science Conference” was held in Bethesda, Maryland hosted by the NCI with the intention of formulating internationally acceptable guidelines for reporting of thyroid cytopathology. This was because, thyroid FNAC have a reporting confusion due to multiplicity of category terminologies. To overcome this, The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) was introduced for unifying the terminology and morphologic criteria along with the corresponding risk of malignancy. The Bethesda system for reporting thyroid cytopathology represents a major step towards standardization, reproducibility, improved clinical significance, and greater predictive value of thyroid fine needle aspirates (FNAs). Aim: The aim of this study was to elucidate the diagnostic utility of the Bethesda system in reporting thyroid FNAs and to assess the effectiveness of FNAC in the evaluation of thyroid nodules by comparing the results with histopathological evaluation. Materials and Methods: The present study was carried out in our institute during the July 2012 to September 2014. In this study, 100 FNACs done which were classified according to the Bethesda system and out of them, 60 histopathological evaluations obtained from this group were evaluated. The sensitivity, specificity, positive and negative predictive values were evaluated. Results: Out of 100 FNACs, 06% were Non-diagnostic, 78% were Benign, 04% were Atypical follicular lesion of undetermined significance (AFLUS), 04% were suspicious for Follicular neoplasm (SFN), 01% were suspicious for Follicular neoplasm Hurthle cell type, 03% were suspicious for malignancy (SM), and 04% malignant. In 60 cases, data of follow-up histopathologic examination (HPE) were available. The sensitivity was 88.89% and specificity was 84.31%. The positive and negative predictive value were 50% and 97.7%, respectively. Conclusion: The Bethesda system is very useful for a standardized system of reporting thyroid cytopathology, improving communication between cytopathologists and clinicians, and inter-laboratory agreement, leading to more consistent management approaches. An additional point which is in favor of the implementation of this system is that the classification is directly related to the risk of malignancy in each category, which in turn, prompts the recommended clinical management of that category, thus truly embodying the clinicopathological correlation in its true spirit. The correlation of FNAC with histopathology is necessary before starting treatment.https://jcdr.net/articles/PDF/6897/14823_CE[Ra1]_F(AK)_PF1(BMAK)_PFA(AK)_PF2(PAG).pdffine needle aspiration cytologypredictive valuesensitivityspecificity |
| spellingShingle | Sameep Garg Nandini J. Desai Dimple Mehta Mitsu Vaishnav To Establish Bethesda System for Diagnosis of Thyroid Nodules on the Basis of Fnac with Histopathological Correlation Journal of Clinical and Diagnostic Research fine needle aspiration cytology predictive value sensitivity specificity |
| title | To Establish Bethesda System for Diagnosis of Thyroid Nodules on the Basis of Fnac with Histopathological Correlation |
| title_full | To Establish Bethesda System for Diagnosis of Thyroid Nodules on the Basis of Fnac with Histopathological Correlation |
| title_fullStr | To Establish Bethesda System for Diagnosis of Thyroid Nodules on the Basis of Fnac with Histopathological Correlation |
| title_full_unstemmed | To Establish Bethesda System for Diagnosis of Thyroid Nodules on the Basis of Fnac with Histopathological Correlation |
| title_short | To Establish Bethesda System for Diagnosis of Thyroid Nodules on the Basis of Fnac with Histopathological Correlation |
| title_sort | to establish bethesda system for diagnosis of thyroid nodules on the basis of fnac with histopathological correlation |
| topic | fine needle aspiration cytology predictive value sensitivity specificity |
| url | https://jcdr.net/articles/PDF/6897/14823_CE[Ra1]_F(AK)_PF1(BMAK)_PFA(AK)_PF2(PAG).pdf |
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