Protein recoding by ADAR1-mediated RNA editing is not essential for normal development and homeostasis

Protein recoding by ADAR1-mediated RNA editing is not essential for normal development and homeostasis

Abstract Background Adenosine-to-inosine (A-to-I) editing of dsRNA by ADAR proteins is a pervasive epitranscriptome feature. Tens of thousands of A-to-I editing events are defined in the mouse, yet the functional impact of most is unknown. Editing causing protein recoding is the essential function o...

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Bibliographic Details
Main Authors: Jacki E. Heraud-Farlow, Alistair M. Chalk, Sandra E. Linder, Qin Li, Scott Taylor, Joshua M. White, Lokman Pang, Brian J. Liddicoat, Ankita Gupte, Jin Billy Li, Carl R. Walkley
Format: Article
Language:English
Published: BMC 2017-09-01
Series:Genome Biology
Subjects:
ADAR1
RNA editing
MDA5
Development
dsRNA
Innate immunity
Online Access:http://link.springer.com/article/10.1186/s13059-017-1301-4

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