The role of IL-6/JAK2/STAT3 signaling pathway in cancers
Interleukin-6 (IL-6) is a pleiotropic cytokine involved in immune regulation. It can activate janus kinase 2 (JAK2)-signal transducer and activator of transcription 3 (STAT3) signaling pathway. As one of the important signal transduction pathways in cells, JAK2/STAT3 signaling pathway plays a critic...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-12-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.1023177/full |
| _version_ | 1798006059733876736 |
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| author | Bei Huang Bei Huang Xiaoling Lang Xiaoling Lang Xihong Li Xihong Li |
| author_facet | Bei Huang Bei Huang Xiaoling Lang Xiaoling Lang Xihong Li Xihong Li |
| author_sort | Bei Huang |
| collection | DOAJ |
| description | Interleukin-6 (IL-6) is a pleiotropic cytokine involved in immune regulation. It can activate janus kinase 2 (JAK2)-signal transducer and activator of transcription 3 (STAT3) signaling pathway. As one of the important signal transduction pathways in cells, JAK2/STAT3 signaling pathway plays a critical role in cell proliferation and differentiation by affecting the activation state of downstream effector molecules. The activation of JAK2/STAT3 signaling pathway is involved in tumorigenesis and development. It contributes to the formation of tumor inflammatory microenvironment and is closely related to the occurrence and development of many human tumors. This article focuses on the relationship between IL-6/JAK2/STAT3 signaling pathway and liver cancer, breast cancer, colorectal cancer, gastric cancer, lung cancer, pancreatic cancer and ovarian cancer, hoping to provide references for the research of cancer treatment targeting key molecules in IL-6/JAK2/STAT3 signaling pathway. |
| first_indexed | 2024-04-11T12:48:56Z |
| format | Article |
| id | doaj.art-c8c2c3b064a646d8afb6337b861e006d |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-11T12:48:56Z |
| publishDate | 2022-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-c8c2c3b064a646d8afb6337b861e006d2022-12-22T04:23:16ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-12-011210.3389/fonc.2022.10231771023177The role of IL-6/JAK2/STAT3 signaling pathway in cancersBei Huang0Bei Huang1Xiaoling Lang2Xiaoling Lang3Xihong Li4Xihong Li5Operational Management Office, West China Second University Hospital, Sichuan University, Chengdu, ChinaKey Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, ChinaOperational Management Office, West China Second University Hospital, Sichuan University, Chengdu, ChinaKey Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, ChinaKey Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, ChinaEmergency Department, West China Second University Hospital, Sichuan University, Chengdu, ChinaInterleukin-6 (IL-6) is a pleiotropic cytokine involved in immune regulation. It can activate janus kinase 2 (JAK2)-signal transducer and activator of transcription 3 (STAT3) signaling pathway. As one of the important signal transduction pathways in cells, JAK2/STAT3 signaling pathway plays a critical role in cell proliferation and differentiation by affecting the activation state of downstream effector molecules. The activation of JAK2/STAT3 signaling pathway is involved in tumorigenesis and development. It contributes to the formation of tumor inflammatory microenvironment and is closely related to the occurrence and development of many human tumors. This article focuses on the relationship between IL-6/JAK2/STAT3 signaling pathway and liver cancer, breast cancer, colorectal cancer, gastric cancer, lung cancer, pancreatic cancer and ovarian cancer, hoping to provide references for the research of cancer treatment targeting key molecules in IL-6/JAK2/STAT3 signaling pathway.https://www.frontiersin.org/articles/10.3389/fonc.2022.1023177/fullIL-6/JAK2/STAT3 signaling pathwayliver cancerbreast cancercolorectal cancergastric cancerlung cancer |
| spellingShingle | Bei Huang Bei Huang Xiaoling Lang Xiaoling Lang Xihong Li Xihong Li The role of IL-6/JAK2/STAT3 signaling pathway in cancers Frontiers in Oncology IL-6/JAK2/STAT3 signaling pathway liver cancer breast cancer colorectal cancer gastric cancer lung cancer |
| title | The role of IL-6/JAK2/STAT3 signaling pathway in cancers |
| title_full | The role of IL-6/JAK2/STAT3 signaling pathway in cancers |
| title_fullStr | The role of IL-6/JAK2/STAT3 signaling pathway in cancers |
| title_full_unstemmed | The role of IL-6/JAK2/STAT3 signaling pathway in cancers |
| title_short | The role of IL-6/JAK2/STAT3 signaling pathway in cancers |
| title_sort | role of il 6 jak2 stat3 signaling pathway in cancers |
| topic | IL-6/JAK2/STAT3 signaling pathway liver cancer breast cancer colorectal cancer gastric cancer lung cancer |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.1023177/full |
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