Association of mannose-binding lectin 2 gene polymorphisms with Guillain-Barré syndrome
Abstract Complement activation plays a critical role in the pathogenesis of Guillain-Barré syndrome (GBS), a debilitating immune-mediated neuropathy. Mannose-binding lectin (MBL) is a complement activation factor of lectin pathway which as genetic host factor may influence the susceptibility or seve...
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| Format: | Article |
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Nature Portfolio
2022-04-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-09621-y |
| _version_ | 1811260813102546944 |
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| author | Israt Jahan Shoma Hayat Mir M. Khalid Rijwan U. Ahammad Asaduzzaman Asad Badrul Islam Quazi D. Mohammad Bart C. Jacobs Zhahirul Islam |
| author_facet | Israt Jahan Shoma Hayat Mir M. Khalid Rijwan U. Ahammad Asaduzzaman Asad Badrul Islam Quazi D. Mohammad Bart C. Jacobs Zhahirul Islam |
| author_sort | Israt Jahan |
| collection | DOAJ |
| description | Abstract Complement activation plays a critical role in the pathogenesis of Guillain-Barré syndrome (GBS), a debilitating immune-mediated neuropathy. Mannose-binding lectin (MBL) is a complement activation factor of lectin pathway which as genetic host factor may influence the susceptibility or severity of GBS. We investigated the frequency of MBL2 promoter (− 550H/L and − 221X/Y) and functional region (exon 1 A/O) polymorphisms and their association with disease susceptibility, clinical features and serum MBL among GBS patients (n = 300) and healthy controls (n = 300) in Bangladesh. The median patient age was 30 years (IQR: 18–42; males, 68%). MBL2 polymorphisms were not significantly associated with GBS susceptibility compared to healthy controls. HL heterozygosity in GBS patients was significantly associated with mild functional disability at enrolment (P = 0.0145, OR, 95% CI 2.1, 1.17–3.82). The HY, YA, HA and HYA heterozygous haplotypes were more common among mildly affected (P = 0.0067, P = 0.0086, P = 0.0075, P = 0.0032, respectively) than severely affected patients with GBS. Reduced serum MBL was significantly associated with the LL, OO and no HYA variants and GBS disease severity. No significant association was observed between MBL2 polymorphisms and electrophysiological variants, recent Campylobacter jejuni infection or anti-ganglioside (GM1) antibody responses in GBS. In conclusion, MBL2 gene polymorphisms are related to reduced serum MBL and associated with the severity of GBS. |
| first_indexed | 2024-04-12T18:53:13Z |
| format | Article |
| id | doaj.art-c8c3149c0d5f49fdb9558745fb2e7cfd |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-12T18:53:13Z |
| publishDate | 2022-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-c8c3149c0d5f49fdb9558745fb2e7cfd2022-12-22T03:20:24ZengNature PortfolioScientific Reports2045-23222022-04-0112111110.1038/s41598-022-09621-yAssociation of mannose-binding lectin 2 gene polymorphisms with Guillain-Barré syndromeIsrat Jahan0Shoma Hayat1Mir M. Khalid2Rijwan U. Ahammad3Asaduzzaman Asad4Badrul Islam5Quazi D. Mohammad6Bart C. Jacobs7Zhahirul Islam8Laboratory of Gut-Brain Signaling, Laboratory Sciences and Services Division, icddr, bLaboratory of Gut-Brain Signaling, Laboratory Sciences and Services Division, icddr, bLaboratory of Gut-Brain Signaling, Laboratory Sciences and Services Division, icddr, bGraduate School of Medicine, Nagoya UniversityLaboratory of Gut-Brain Signaling, Laboratory Sciences and Services Division, icddr, bLaboratory of Gut-Brain Signaling, Laboratory Sciences and Services Division, icddr, bNational Institute of Neurosciences and HospitalDepartment of Neurology and Immunology, Erasmus MC, University Medical CenterLaboratory of Gut-Brain Signaling, Laboratory Sciences and Services Division, icddr, bAbstract Complement activation plays a critical role in the pathogenesis of Guillain-Barré syndrome (GBS), a debilitating immune-mediated neuropathy. Mannose-binding lectin (MBL) is a complement activation factor of lectin pathway which as genetic host factor may influence the susceptibility or severity of GBS. We investigated the frequency of MBL2 promoter (− 550H/L and − 221X/Y) and functional region (exon 1 A/O) polymorphisms and their association with disease susceptibility, clinical features and serum MBL among GBS patients (n = 300) and healthy controls (n = 300) in Bangladesh. The median patient age was 30 years (IQR: 18–42; males, 68%). MBL2 polymorphisms were not significantly associated with GBS susceptibility compared to healthy controls. HL heterozygosity in GBS patients was significantly associated with mild functional disability at enrolment (P = 0.0145, OR, 95% CI 2.1, 1.17–3.82). The HY, YA, HA and HYA heterozygous haplotypes were more common among mildly affected (P = 0.0067, P = 0.0086, P = 0.0075, P = 0.0032, respectively) than severely affected patients with GBS. Reduced serum MBL was significantly associated with the LL, OO and no HYA variants and GBS disease severity. No significant association was observed between MBL2 polymorphisms and electrophysiological variants, recent Campylobacter jejuni infection or anti-ganglioside (GM1) antibody responses in GBS. In conclusion, MBL2 gene polymorphisms are related to reduced serum MBL and associated with the severity of GBS.https://doi.org/10.1038/s41598-022-09621-y |
| spellingShingle | Israt Jahan Shoma Hayat Mir M. Khalid Rijwan U. Ahammad Asaduzzaman Asad Badrul Islam Quazi D. Mohammad Bart C. Jacobs Zhahirul Islam Association of mannose-binding lectin 2 gene polymorphisms with Guillain-Barré syndrome Scientific Reports |
| title | Association of mannose-binding lectin 2 gene polymorphisms with Guillain-Barré syndrome |
| title_full | Association of mannose-binding lectin 2 gene polymorphisms with Guillain-Barré syndrome |
| title_fullStr | Association of mannose-binding lectin 2 gene polymorphisms with Guillain-Barré syndrome |
| title_full_unstemmed | Association of mannose-binding lectin 2 gene polymorphisms with Guillain-Barré syndrome |
| title_short | Association of mannose-binding lectin 2 gene polymorphisms with Guillain-Barré syndrome |
| title_sort | association of mannose binding lectin 2 gene polymorphisms with guillain barre syndrome |
| url | https://doi.org/10.1038/s41598-022-09621-y |
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