Focused Ultrasound Stimulation as a Neuromodulatory Tool for Parkinson’s Disease: A Scoping Review
Non-invasive focused ultrasound stimulation (FUS) is a non-ionising neuromodulatory technique that employs acoustic energy to acutely and reversibly modulate brain activity of deep-brain structures. It is currently being investigated as a potential novel treatment for Parkinson’s disease (PD). This...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-02-01
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| Series: | Brain Sciences |
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| Online Access: | https://www.mdpi.com/2076-3425/12/2/289 |
| _version_ | 1797482166304636928 |
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| author | Keng Siang Lee Benjamin Clennell Tom G. J. Steward Andriana Gialeli Oscar Cordero-Llana Daniel J. Whitcomb |
| author_facet | Keng Siang Lee Benjamin Clennell Tom G. J. Steward Andriana Gialeli Oscar Cordero-Llana Daniel J. Whitcomb |
| author_sort | Keng Siang Lee |
| collection | DOAJ |
| description | Non-invasive focused ultrasound stimulation (FUS) is a non-ionising neuromodulatory technique that employs acoustic energy to acutely and reversibly modulate brain activity of deep-brain structures. It is currently being investigated as a potential novel treatment for Parkinson’s disease (PD). This scoping review was carried out to map available evidence pertaining to the provision of FUS as a PD neuromodulatory tool. In accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analysis Extension for Scoping Reviews, a search was applied to Ovid MEDLINE, Embase, Web of Science and Cochrane Central Register of Controlled Trials on 13 January 2022, with no limits applied. In total, 11 studies were included: 8 were from China and 1 each from Belgium, South Korea and Taiwan. All 11 studies were preclinical (6 <i>in vivo</i>, 2 <i>in vitro</i>, 2 mix of <i>in vivo</i> and <i>in vitro</i> and 1 <i>in silico</i>). The preclinical evidence indicates that FUS is safe and has beneficial neuromodulatory effects on motor behaviour in PD. FUS appears to have a therapeutic role in influencing the disease processes of PD, and therefore holds great promise as an attractive and powerful neuromodulatory tool for PD. Though these initial studies are encouraging, further study to understand the underlying cellular and molecular mechanisms is required before FUS can be routinely used in PD. |
| first_indexed | 2024-03-09T22:27:19Z |
| format | Article |
| id | doaj.art-c8c4e6a9765846259a5d4a46b2c057fe |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-09T22:27:19Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-c8c4e6a9765846259a5d4a46b2c057fe2023-11-23T19:04:34ZengMDPI AGBrain Sciences2076-34252022-02-0112228910.3390/brainsci12020289Focused Ultrasound Stimulation as a Neuromodulatory Tool for Parkinson’s Disease: A Scoping ReviewKeng Siang Lee0Benjamin Clennell1Tom G. J. Steward2Andriana Gialeli3Oscar Cordero-Llana4Daniel J. Whitcomb5Bristol Medical School, Faculty of Health Sciences, University of Bristol, Bristol BS8 1TH, UKBristol Medical School, Faculty of Health Sciences, University of Bristol, Bristol BS8 1TH, UKBristol Medical School, Faculty of Health Sciences, University of Bristol, Bristol BS8 1TH, UKBristol Medical School, Faculty of Health Sciences, University of Bristol, Bristol BS8 1TH, UKBristol Medical School, Faculty of Health Sciences, University of Bristol, Bristol BS8 1TH, UKBristol Medical School, Faculty of Health Sciences, University of Bristol, Bristol BS8 1TH, UKNon-invasive focused ultrasound stimulation (FUS) is a non-ionising neuromodulatory technique that employs acoustic energy to acutely and reversibly modulate brain activity of deep-brain structures. It is currently being investigated as a potential novel treatment for Parkinson’s disease (PD). This scoping review was carried out to map available evidence pertaining to the provision of FUS as a PD neuromodulatory tool. In accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analysis Extension for Scoping Reviews, a search was applied to Ovid MEDLINE, Embase, Web of Science and Cochrane Central Register of Controlled Trials on 13 January 2022, with no limits applied. In total, 11 studies were included: 8 were from China and 1 each from Belgium, South Korea and Taiwan. All 11 studies were preclinical (6 <i>in vivo</i>, 2 <i>in vitro</i>, 2 mix of <i>in vivo</i> and <i>in vitro</i> and 1 <i>in silico</i>). The preclinical evidence indicates that FUS is safe and has beneficial neuromodulatory effects on motor behaviour in PD. FUS appears to have a therapeutic role in influencing the disease processes of PD, and therefore holds great promise as an attractive and powerful neuromodulatory tool for PD. Though these initial studies are encouraging, further study to understand the underlying cellular and molecular mechanisms is required before FUS can be routinely used in PD.https://www.mdpi.com/2076-3425/12/2/289neuroscienceneuromodulationParkinson’s diseasescoping reviewultrasound |
| spellingShingle | Keng Siang Lee Benjamin Clennell Tom G. J. Steward Andriana Gialeli Oscar Cordero-Llana Daniel J. Whitcomb Focused Ultrasound Stimulation as a Neuromodulatory Tool for Parkinson’s Disease: A Scoping Review Brain Sciences neuroscience neuromodulation Parkinson’s disease scoping review ultrasound |
| title | Focused Ultrasound Stimulation as a Neuromodulatory Tool for Parkinson’s Disease: A Scoping Review |
| title_full | Focused Ultrasound Stimulation as a Neuromodulatory Tool for Parkinson’s Disease: A Scoping Review |
| title_fullStr | Focused Ultrasound Stimulation as a Neuromodulatory Tool for Parkinson’s Disease: A Scoping Review |
| title_full_unstemmed | Focused Ultrasound Stimulation as a Neuromodulatory Tool for Parkinson’s Disease: A Scoping Review |
| title_short | Focused Ultrasound Stimulation as a Neuromodulatory Tool for Parkinson’s Disease: A Scoping Review |
| title_sort | focused ultrasound stimulation as a neuromodulatory tool for parkinson s disease a scoping review |
| topic | neuroscience neuromodulation Parkinson’s disease scoping review ultrasound |
| url | https://www.mdpi.com/2076-3425/12/2/289 |
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