GATA6 Plays an Important Role in the Induction of Human Definitive Endoderm, Development of the Pancreas, and Functionality of Pancreatic β Cells

GATA6 Plays an Important Role in the Induction of Human Definitive Endoderm, Development of the Pancreas, and Functionality of Pancreatic β Cells

Induced pluripotent stem cells were created from a pancreas agenesis patient with a mutation in GATA6. Using genome-editing technology, additional stem cell lines with mutations in both GATA6 alleles were generated and demonstrated a severe block in definitive endoderm induction, which could be resc...

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Bibliographic Details
Main Authors: Amita Tiyaboonchai, Fabian L. Cardenas-Diaz, Lei Ying, Jean Ann Maguire, Xiuli Sim, Chintan Jobaliya, Alyssa L. Gagne, Siddharth Kishore, Diana E. Stanescu, Nkecha Hughes, Diva D. De Leon, Deborah L. French, Paul Gadue
Format: Article
Language:English
Published: Elsevier 2017-03-01
Series:Stem Cell Reports
Subjects:
GATA6
stem cells
pancreatic agenesis
definitive endoderm
β cell
retinoic acid
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671116303162

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