A descriptive analysis of antimicrobial resistance patterns of WHO priority pathogens isolated in children from a tertiary care hospital in India
Abstract The World Health Organization (WHO) has articulated a priority pathogens list (PPL) to provide strategic direction to research and develop new antimicrobials. Antimicrobial resistance (AMR) patterns of WHO PPL in a tertiary health care facility in Southern India were explored to understand...
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Nature Portfolio
2021-03-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-021-84293-8 |
| _version_ | 1818436095758565376 |
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| author | Vijayalaxmi V. Mogasale Prakash Saldanha Vidya Pai P. D. Rekha Vittal Mogasale |
| author_facet | Vijayalaxmi V. Mogasale Prakash Saldanha Vidya Pai P. D. Rekha Vittal Mogasale |
| author_sort | Vijayalaxmi V. Mogasale |
| collection | DOAJ |
| description | Abstract The World Health Organization (WHO) has articulated a priority pathogens list (PPL) to provide strategic direction to research and develop new antimicrobials. Antimicrobial resistance (AMR) patterns of WHO PPL in a tertiary health care facility in Southern India were explored to understand the local priority pathogens. Culture reports of laboratory specimens collected between 1st January 2014 and 31st October 2019 from paediatric patients were extracted. The antimicrobial susceptibility patterns for selected antimicrobials on the WHO PPL were analysed and reported. Of 12,256 culture specimens screened, 2335 (19%) showed culture positivity, of which 1556 (66.6%) were organisms from the WHO-PPL. E. coli was the most common organism isolated (37%), followed by Staphylococcus aureus (16%). Total of 72% of E. coli were extended-spectrum beta-lactamases (ESBL) producers, 55% of Enterobacteriaceae were resistant to 3rd generation cephalosporins due to ESBL, and 53% of Staph. aureus were Methicillin-resistant. The analysis showed AMR trends and prevalence patterns in the study setting and the WHO-PPL document are not fully comparable. This kind of local priority difference needs to be recognised in local policies and practices. |
| first_indexed | 2024-12-14T17:03:20Z |
| format | Article |
| id | doaj.art-c8c75d60973f49db9bce145944e9e99a |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-14T17:03:20Z |
| publishDate | 2021-03-01 |
| publisher | Nature Portfolio |
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| spelling | doaj.art-c8c75d60973f49db9bce145944e9e99a2022-12-21T22:53:48ZengNature PortfolioScientific Reports2045-23222021-03-011111710.1038/s41598-021-84293-8A descriptive analysis of antimicrobial resistance patterns of WHO priority pathogens isolated in children from a tertiary care hospital in IndiaVijayalaxmi V. Mogasale0Prakash Saldanha1Vidya Pai2P. D. Rekha3Vittal Mogasale4Department of Paediatrics, Yenepoya Medical CollegeDepartment of Paediatrics, Yenepoya Medical CollegeDepartment of Microbiology, Yenepoya Medical CollegeYenepoya Research Centre, Yenepoya (Deemed to be) UniversityPolicy and Economic Research Department, International Vaccine InstituteAbstract The World Health Organization (WHO) has articulated a priority pathogens list (PPL) to provide strategic direction to research and develop new antimicrobials. Antimicrobial resistance (AMR) patterns of WHO PPL in a tertiary health care facility in Southern India were explored to understand the local priority pathogens. Culture reports of laboratory specimens collected between 1st January 2014 and 31st October 2019 from paediatric patients were extracted. The antimicrobial susceptibility patterns for selected antimicrobials on the WHO PPL were analysed and reported. Of 12,256 culture specimens screened, 2335 (19%) showed culture positivity, of which 1556 (66.6%) were organisms from the WHO-PPL. E. coli was the most common organism isolated (37%), followed by Staphylococcus aureus (16%). Total of 72% of E. coli were extended-spectrum beta-lactamases (ESBL) producers, 55% of Enterobacteriaceae were resistant to 3rd generation cephalosporins due to ESBL, and 53% of Staph. aureus were Methicillin-resistant. The analysis showed AMR trends and prevalence patterns in the study setting and the WHO-PPL document are not fully comparable. This kind of local priority difference needs to be recognised in local policies and practices.https://doi.org/10.1038/s41598-021-84293-8 |
| spellingShingle | Vijayalaxmi V. Mogasale Prakash Saldanha Vidya Pai P. D. Rekha Vittal Mogasale A descriptive analysis of antimicrobial resistance patterns of WHO priority pathogens isolated in children from a tertiary care hospital in India Scientific Reports |
| title | A descriptive analysis of antimicrobial resistance patterns of WHO priority pathogens isolated in children from a tertiary care hospital in India |
| title_full | A descriptive analysis of antimicrobial resistance patterns of WHO priority pathogens isolated in children from a tertiary care hospital in India |
| title_fullStr | A descriptive analysis of antimicrobial resistance patterns of WHO priority pathogens isolated in children from a tertiary care hospital in India |
| title_full_unstemmed | A descriptive analysis of antimicrobial resistance patterns of WHO priority pathogens isolated in children from a tertiary care hospital in India |
| title_short | A descriptive analysis of antimicrobial resistance patterns of WHO priority pathogens isolated in children from a tertiary care hospital in India |
| title_sort | descriptive analysis of antimicrobial resistance patterns of who priority pathogens isolated in children from a tertiary care hospital in india |
| url | https://doi.org/10.1038/s41598-021-84293-8 |
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