Investigation on submicron particle separation and deflection using tilted-angle standing surface acoustic wave microfluidics
With the development of in vitro diagnostics, extracting submicron scale particles from mixed body fluids samples is crucial. In recent years, microfluidic separation has attracted much attention due to its high efficiency, label-free, and inexpensive nature. Among the microfluidic-based separation,...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-02-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844024010739 |
| _version_ | 1827348385469825024 |
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| author | Tao Peng Xiaodong Lin Luming Li Lei Huang Bingyan Jiang Yanwei Jia |
| author_facet | Tao Peng Xiaodong Lin Luming Li Lei Huang Bingyan Jiang Yanwei Jia |
| author_sort | Tao Peng |
| collection | DOAJ |
| description | With the development of in vitro diagnostics, extracting submicron scale particles from mixed body fluids samples is crucial. In recent years, microfluidic separation has attracted much attention due to its high efficiency, label-free, and inexpensive nature. Among the microfluidic-based separation, the separation based on ultrasonic standing waves has gradually become a powerful tool. A microfluid environment containing a tilted-angle ultrasonic standing surface acoustic wave (taSSAW) field has been widely adapted and designed to separate submicron particles for biochemical applications. This paper investigated submicron particle defection in microfluidics using taSSAWs analytically. Particles with 0.1–1 μm diameters were analyzed under acoustic pressure, flow rate, tilted angle, and SSAW frequency. According to different acoustic radiation forces acting on the particles, the motion of large-diameter particles was more likely to deflect to the direction of the nodal lines. Decreasing the input flow rate or increasing acoustic pressure and acoustic wave frequency can improve particle deflection. The tilted angle can be optimized by analyzing the simulation results. Based on the simulation analysis, we experimentally showed the separation of polystyrene microspheres (100 nm) from the mixed particles and exosomes (30–150 nm) from human plasma. This research results can provide a certain reference for the practical design of bioparticle separation utilizing acoustofluidic devices. |
| first_indexed | 2024-03-08T00:11:29Z |
| format | Article |
| id | doaj.art-c8c9f919926c48398bf4d49f141998d5 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-03-08T00:11:29Z |
| publishDate | 2024-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-c8c9f919926c48398bf4d49f141998d52024-02-17T06:39:24ZengElsevierHeliyon2405-84402024-02-01103e25042Investigation on submicron particle separation and deflection using tilted-angle standing surface acoustic wave microfluidicsTao Peng0Xiaodong Lin1Luming Li2Lei Huang3Bingyan Jiang4Yanwei Jia5Zhuhai UM Science & Technology Research Institute, Zhuhai, China; Corresponding author.Zhuhai UM Science & Technology Research Institute, Zhuhai, ChinaState Key Laboratory of High-Performance Complex Manufacturing, College of Mechanical and Electrical Engineering, Central South University, Changsha, 410083, ChinaState Key Laboratory of High-Performance Complex Manufacturing, College of Mechanical and Electrical Engineering, Central South University, Changsha, 410083, ChinaState Key Laboratory of High-Performance Complex Manufacturing, College of Mechanical and Electrical Engineering, Central South University, Changsha, 410083, China; Corresponding author.Zhuhai UM Science & Technology Research Institute, Zhuhai, China; State Key Laboratory of Analog and Mixed-Signal VLSI, Institute of Microelectronics, University of Macau, Macau, China; Faculty of Science and Technology – Electrical and Computer Engineering, University of Macau, Macau, China; MoE Frontiers Science Center for Precision Oncology, University of Macau, Macau, China; Corresponding author. Zhuhai UM Science & Technology Research Institute, Zhuhai, China.With the development of in vitro diagnostics, extracting submicron scale particles from mixed body fluids samples is crucial. In recent years, microfluidic separation has attracted much attention due to its high efficiency, label-free, and inexpensive nature. Among the microfluidic-based separation, the separation based on ultrasonic standing waves has gradually become a powerful tool. A microfluid environment containing a tilted-angle ultrasonic standing surface acoustic wave (taSSAW) field has been widely adapted and designed to separate submicron particles for biochemical applications. This paper investigated submicron particle defection in microfluidics using taSSAWs analytically. Particles with 0.1–1 μm diameters were analyzed under acoustic pressure, flow rate, tilted angle, and SSAW frequency. According to different acoustic radiation forces acting on the particles, the motion of large-diameter particles was more likely to deflect to the direction of the nodal lines. Decreasing the input flow rate or increasing acoustic pressure and acoustic wave frequency can improve particle deflection. The tilted angle can be optimized by analyzing the simulation results. Based on the simulation analysis, we experimentally showed the separation of polystyrene microspheres (100 nm) from the mixed particles and exosomes (30–150 nm) from human plasma. This research results can provide a certain reference for the practical design of bioparticle separation utilizing acoustofluidic devices.http://www.sciencedirect.com/science/article/pii/S2405844024010739Submicron particlesAcoustic radiationMicrofluidic separationAcoustofluidics |
| spellingShingle | Tao Peng Xiaodong Lin Luming Li Lei Huang Bingyan Jiang Yanwei Jia Investigation on submicron particle separation and deflection using tilted-angle standing surface acoustic wave microfluidics Heliyon Submicron particles Acoustic radiation Microfluidic separation Acoustofluidics |
| title | Investigation on submicron particle separation and deflection using tilted-angle standing surface acoustic wave microfluidics |
| title_full | Investigation on submicron particle separation and deflection using tilted-angle standing surface acoustic wave microfluidics |
| title_fullStr | Investigation on submicron particle separation and deflection using tilted-angle standing surface acoustic wave microfluidics |
| title_full_unstemmed | Investigation on submicron particle separation and deflection using tilted-angle standing surface acoustic wave microfluidics |
| title_short | Investigation on submicron particle separation and deflection using tilted-angle standing surface acoustic wave microfluidics |
| title_sort | investigation on submicron particle separation and deflection using tilted angle standing surface acoustic wave microfluidics |
| topic | Submicron particles Acoustic radiation Microfluidic separation Acoustofluidics |
| url | http://www.sciencedirect.com/science/article/pii/S2405844024010739 |
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