Investigating the influence of ubiquinone blood level on the abilities of children with specific learning disorder
Abstract Background Ubiquinone has antioxidant properties and has been linked to cognitive performance in some neuropsychiatric disorders. Its role in specific learning disorder manifestations has not been previously investigated. Therefore, the aim of this study was to measure the blood levels of u...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SpringerOpen
2018-11-01
|
| Series: | The Egyptian Journal of Neurology, Psychiatry and Neurosurgery |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s41983-018-0029-8 |
| _version_ | 1831656135492370432 |
|---|---|
| author | Ehab Ragaa Abdelraouf Ayman Kilany Adel F. Hashish Ola Hosny Gebril Suzette Ibrahim Helal Haytham Mohamad Hasan Neveen Hassan Nashaat |
| author_facet | Ehab Ragaa Abdelraouf Ayman Kilany Adel F. Hashish Ola Hosny Gebril Suzette Ibrahim Helal Haytham Mohamad Hasan Neveen Hassan Nashaat |
| author_sort | Ehab Ragaa Abdelraouf |
| collection | DOAJ |
| description | Abstract Background Ubiquinone has antioxidant properties and has been linked to cognitive performance in some neuropsychiatric disorders. Its role in specific learning disorder manifestations has not been previously investigated. Therefore, the aim of this study was to measure the blood levels of ubiquinone in a group of children with specific learning disorder in comparison to typically developing children and to investigate the correlation between ubiquinone levels in children with specific learning disorder and some of their intellectual capabilities, reading, spelling and writing performance. Methods The study included 71 native Arabic speaking children: 31 in the specific learning disorder group and 40 in the typically developing (TD) group. The abilities of the children with specific learning disorder were evaluated by the Stanford-Binet Intelligence Scale-4th edition, the Dyslexia Assessment Test, and the Illinois Test of Psycholinguistic Abilities. The level of ubiquinone was measured in both groups by ELISA. Correlation between some aptitudes of children with specific learning disorder and the ubiquinone level was performed. Results The blood levels of ubiquinone in the children with specific learning disorder group were less than those in the TD group. Correlation analysis revealed a significant positive correlation between ubiquinone and the scores of backward digit span abilities. Conclusions Ubiquinone has a role in the auditory working memory performance of children with specific learning disorder (with impairment in reading). The decreased levels of ubiquinone in this sample of children with specific learning disorder could have participated in the pathogenesis of this disorder. |
| first_indexed | 2024-12-19T17:02:23Z |
| format | Article |
| id | doaj.art-c8caee9da45f492cbd15cdbb247edb2a |
| institution | Directory Open Access Journal |
| issn | 1687-8329 |
| language | English |
| last_indexed | 2024-12-19T17:02:23Z |
| publishDate | 2018-11-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | The Egyptian Journal of Neurology, Psychiatry and Neurosurgery |
| spelling | doaj.art-c8caee9da45f492cbd15cdbb247edb2a2022-12-21T20:13:17ZengSpringerOpenThe Egyptian Journal of Neurology, Psychiatry and Neurosurgery1687-83292018-11-015411510.1186/s41983-018-0029-8Investigating the influence of ubiquinone blood level on the abilities of children with specific learning disorderEhab Ragaa Abdelraouf0Ayman Kilany1Adel F. Hashish2Ola Hosny Gebril3Suzette Ibrahim Helal4Haytham Mohamad Hasan5Neveen Hassan Nashaat6Research on Children with Special Needs Department, Medical Research division, National Research CentreResearch on Children with Special Needs Department, Medical Research division, National Research CentreResearch on Children with Special Needs Department, Medical Research division, National Research CentreResearch on Children with Special Needs Department, Medical Research division, National Research CentreResearch on Children with Special Needs Department, Medical Research division, National Research CentreResearch on Children with Special Needs Department, Medical Research division, National Research CentreResearch on Children with Special Needs Department, Medical Research division, National Research CentreAbstract Background Ubiquinone has antioxidant properties and has been linked to cognitive performance in some neuropsychiatric disorders. Its role in specific learning disorder manifestations has not been previously investigated. Therefore, the aim of this study was to measure the blood levels of ubiquinone in a group of children with specific learning disorder in comparison to typically developing children and to investigate the correlation between ubiquinone levels in children with specific learning disorder and some of their intellectual capabilities, reading, spelling and writing performance. Methods The study included 71 native Arabic speaking children: 31 in the specific learning disorder group and 40 in the typically developing (TD) group. The abilities of the children with specific learning disorder were evaluated by the Stanford-Binet Intelligence Scale-4th edition, the Dyslexia Assessment Test, and the Illinois Test of Psycholinguistic Abilities. The level of ubiquinone was measured in both groups by ELISA. Correlation between some aptitudes of children with specific learning disorder and the ubiquinone level was performed. Results The blood levels of ubiquinone in the children with specific learning disorder group were less than those in the TD group. Correlation analysis revealed a significant positive correlation between ubiquinone and the scores of backward digit span abilities. Conclusions Ubiquinone has a role in the auditory working memory performance of children with specific learning disorder (with impairment in reading). The decreased levels of ubiquinone in this sample of children with specific learning disorder could have participated in the pathogenesis of this disorder.http://link.springer.com/article/10.1186/s41983-018-0029-8Specific learning disorderUbiquinone levelCorrelationMemory |
| spellingShingle | Ehab Ragaa Abdelraouf Ayman Kilany Adel F. Hashish Ola Hosny Gebril Suzette Ibrahim Helal Haytham Mohamad Hasan Neveen Hassan Nashaat Investigating the influence of ubiquinone blood level on the abilities of children with specific learning disorder The Egyptian Journal of Neurology, Psychiatry and Neurosurgery Specific learning disorder Ubiquinone level Correlation Memory |
| title | Investigating the influence of ubiquinone blood level on the abilities of children with specific learning disorder |
| title_full | Investigating the influence of ubiquinone blood level on the abilities of children with specific learning disorder |
| title_fullStr | Investigating the influence of ubiquinone blood level on the abilities of children with specific learning disorder |
| title_full_unstemmed | Investigating the influence of ubiquinone blood level on the abilities of children with specific learning disorder |
| title_short | Investigating the influence of ubiquinone blood level on the abilities of children with specific learning disorder |
| title_sort | investigating the influence of ubiquinone blood level on the abilities of children with specific learning disorder |
| topic | Specific learning disorder Ubiquinone level Correlation Memory |
| url | http://link.springer.com/article/10.1186/s41983-018-0029-8 |
| work_keys_str_mv | AT ehabragaaabdelraouf investigatingtheinfluenceofubiquinonebloodlevelontheabilitiesofchildrenwithspecificlearningdisorder AT aymankilany investigatingtheinfluenceofubiquinonebloodlevelontheabilitiesofchildrenwithspecificlearningdisorder AT adelfhashish investigatingtheinfluenceofubiquinonebloodlevelontheabilitiesofchildrenwithspecificlearningdisorder AT olahosnygebril investigatingtheinfluenceofubiquinonebloodlevelontheabilitiesofchildrenwithspecificlearningdisorder AT suzetteibrahimhelal investigatingtheinfluenceofubiquinonebloodlevelontheabilitiesofchildrenwithspecificlearningdisorder AT haythammohamadhasan investigatingtheinfluenceofubiquinonebloodlevelontheabilitiesofchildrenwithspecificlearningdisorder AT neveenhassannashaat investigatingtheinfluenceofubiquinonebloodlevelontheabilitiesofchildrenwithspecificlearningdisorder |