Platelet indices in graves disease, especially plateletcrit
Graves disease is an autoimmune thyrotoxicosis caused by thyroid receptor antibody and occurs in 1% of the population. Autoimmune events develop against cells in various tissues, including platelets. Platelet lymphocyte interaction can regulate these events. We investigated this relationship in our...
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| Format: | Article |
| Language: | English |
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Society of Turaz Bilim
2020-06-01
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| Series: | Medicine Science |
| Subjects: | |
| Online Access: | http://www.ejmanager.com/fulltextpdf.php?mno=77679 |
| _version_ | 1797329181311238144 |
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| author | Saliha Yildiz Elif Eker |
| author_facet | Saliha Yildiz Elif Eker |
| author_sort | Saliha Yildiz |
| collection | DOAJ |
| description | Graves disease is an autoimmune thyrotoxicosis caused by thyroid receptor antibody and occurs in 1% of the population. Autoimmune events develop against cells in various tissues, including platelets. Platelet lymphocyte interaction can regulate these events. We investigated this relationship in our study. We compared leukocyte and platelet indices in 66 Graves patients and 38 control patients from hemogram parameters prospectively. Lymphocyte count, neutrophil count, platelet lymphocyte ratio, neutrophil lymphocyte ratio was insignificant between the two groups (p: 0.51, 0.13, 0.19, 0.097, respectively). Platelet count, PDW and PCT were significantly higher in Graves patients (p: 0.02, 0.03, 0.00, respectively), and MPV was significantly lower (p: 0.007). In the ROC curve analysis, the PCT threshold value was 0.24. Platelet indices in graves patients and especially PCT were more correlated with the disease than other hemogram parameters. This finding may help to clarify the pathogenesis of the disease. [Med-Science 2020; 9(2.000): 338-42] |
| first_indexed | 2024-03-08T07:02:07Z |
| format | Article |
| id | doaj.art-c8cdf1c6543a49f5aecbe57040f7354e |
| institution | Directory Open Access Journal |
| issn | 2147-0634 |
| language | English |
| last_indexed | 2024-03-08T07:02:07Z |
| publishDate | 2020-06-01 |
| publisher | Society of Turaz Bilim |
| record_format | Article |
| series | Medicine Science |
| spelling | doaj.art-c8cdf1c6543a49f5aecbe57040f7354e2024-02-03T05:37:15ZengSociety of Turaz BilimMedicine Science2147-06342020-06-01923384210.5455/medscience.2019.08.919477679Platelet indices in graves disease, especially plateletcritSaliha Yildiz0Elif EkerVan Yuzuncu Yil University, Faculty of Medicine, Department of Endocrinology, Van, Turkey Van Regional Research and Education Hospital, Department of Internal Medicine, Van, TurkeyGraves disease is an autoimmune thyrotoxicosis caused by thyroid receptor antibody and occurs in 1% of the population. Autoimmune events develop against cells in various tissues, including platelets. Platelet lymphocyte interaction can regulate these events. We investigated this relationship in our study. We compared leukocyte and platelet indices in 66 Graves patients and 38 control patients from hemogram parameters prospectively. Lymphocyte count, neutrophil count, platelet lymphocyte ratio, neutrophil lymphocyte ratio was insignificant between the two groups (p: 0.51, 0.13, 0.19, 0.097, respectively). Platelet count, PDW and PCT were significantly higher in Graves patients (p: 0.02, 0.03, 0.00, respectively), and MPV was significantly lower (p: 0.007). In the ROC curve analysis, the PCT threshold value was 0.24. Platelet indices in graves patients and especially PCT were more correlated with the disease than other hemogram parameters. This finding may help to clarify the pathogenesis of the disease. [Med-Science 2020; 9(2.000): 338-42]http://www.ejmanager.com/fulltextpdf.php?mno=77679graves diseaseplatelet indicesplateletcrit |
| spellingShingle | Saliha Yildiz Elif Eker Platelet indices in graves disease, especially plateletcrit Medicine Science graves disease platelet indices plateletcrit |
| title | Platelet indices in graves disease, especially plateletcrit |
| title_full | Platelet indices in graves disease, especially plateletcrit |
| title_fullStr | Platelet indices in graves disease, especially plateletcrit |
| title_full_unstemmed | Platelet indices in graves disease, especially plateletcrit |
| title_short | Platelet indices in graves disease, especially plateletcrit |
| title_sort | platelet indices in graves disease especially plateletcrit |
| topic | graves disease platelet indices plateletcrit |
| url | http://www.ejmanager.com/fulltextpdf.php?mno=77679 |
| work_keys_str_mv | AT salihayildiz plateletindicesingravesdiseaseespeciallyplateletcrit AT elifeker plateletindicesingravesdiseaseespeciallyplateletcrit |