Tetanus Toxin Fragment C: Structure, Drug Discovery Research and Production
Tetanus toxoid (TTd) plays an important role in the pharmaceutical world, especially in vaccines. The toxoid is obtained after formaldehyde treatment of the tetanus toxin. In parallel, current emphasis in the drug discovery field is put on producing well-defined and safer drugs, explaining the inter...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-06-01
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| Series: | Pharmaceuticals |
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| Online Access: | https://www.mdpi.com/1424-8247/15/6/756 |
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| author | Caroline Bayart Angélique Mularoni Nada Hemmani Soumeya Kerachni Joachim Jose Patrice Gouet Joseph Paladino Marc Le Borgne |
| author_facet | Caroline Bayart Angélique Mularoni Nada Hemmani Soumeya Kerachni Joachim Jose Patrice Gouet Joseph Paladino Marc Le Borgne |
| author_sort | Caroline Bayart |
| collection | DOAJ |
| description | Tetanus toxoid (TTd) plays an important role in the pharmaceutical world, especially in vaccines. The toxoid is obtained after formaldehyde treatment of the tetanus toxin. In parallel, current emphasis in the drug discovery field is put on producing well-defined and safer drugs, explaining the interest in finding new alternative proteins. The tetanus toxin fragment C (TTFC) has been extensively studied both as a neuroprotective agent for central nervous system disorders owing to its neuronal properties and as a carrier protein in vaccines. Indeed, it is derived from a part of the tetanus toxin and, as such, retains its immunogenic properties without being toxic. Moreover, this fragment has been well characterized, and its entire structure is known. Here, we propose a systematic review of TTFC by providing information about its structural features, its properties and its methods of production. We also describe the large uses of TTFC in the field of drug discovery. TTFC can therefore be considered as an attractive alternative to TTd and remarkably offers a wide range of uses, including as a carrier, delivery vector, conjugate, booster, inducer, and neuroprotector. |
| first_indexed | 2024-03-09T22:46:50Z |
| format | Article |
| id | doaj.art-c8ce40a7c2764f25ba9b96a34119e600 |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-03-09T22:46:50Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-c8ce40a7c2764f25ba9b96a34119e6002023-11-23T18:28:11ZengMDPI AGPharmaceuticals1424-82472022-06-0115675610.3390/ph15060756Tetanus Toxin Fragment C: Structure, Drug Discovery Research and ProductionCaroline Bayart0Angélique Mularoni1Nada Hemmani2Soumeya Kerachni3Joachim Jose4Patrice Gouet5Joseph Paladino6Marc Le Borgne7Analytical Sciences, Sanofi, 31/33 Quai Armand Barbès, 69250 Neuville-sur-Saône, FranceSmall Molecules for Biological Targets Team, Centre de Recherche en Cancérologie de Lyon, Centre Léon Bérard, CNRS 5286, INSERM 1052, Université Claude Bernard Lyon 1, Univ Lyon, 69373 Lyon, FranceSmall Molecules for Biological Targets Team, Centre de Recherche en Cancérologie de Lyon, Centre Léon Bérard, CNRS 5286, INSERM 1052, Université Claude Bernard Lyon 1, Univ Lyon, 69373 Lyon, FranceSmall Molecules for Biological Targets Team, Centre de Recherche en Cancérologie de Lyon, Centre Léon Bérard, CNRS 5286, INSERM 1052, Université Claude Bernard Lyon 1, Univ Lyon, 69373 Lyon, FranceInstitute of Pharmaceutical and Medicinal Chemistry, PharmaCampus, Westfälische Wilhelms-Universtität Münster, 48149 Münster, GermanyUMR 5086, Molecular Microbiology and Structural Biochemistry, CNRS/Université Lyon 1, 69367 Lyon, FranceAnalytical Sciences, Sanofi, 31/33 Quai Armand Barbès, 69250 Neuville-sur-Saône, FranceSmall Molecules for Biological Targets Team, Centre de Recherche en Cancérologie de Lyon, Centre Léon Bérard, CNRS 5286, INSERM 1052, Université Claude Bernard Lyon 1, Univ Lyon, 69373 Lyon, FranceTetanus toxoid (TTd) plays an important role in the pharmaceutical world, especially in vaccines. The toxoid is obtained after formaldehyde treatment of the tetanus toxin. In parallel, current emphasis in the drug discovery field is put on producing well-defined and safer drugs, explaining the interest in finding new alternative proteins. The tetanus toxin fragment C (TTFC) has been extensively studied both as a neuroprotective agent for central nervous system disorders owing to its neuronal properties and as a carrier protein in vaccines. Indeed, it is derived from a part of the tetanus toxin and, as such, retains its immunogenic properties without being toxic. Moreover, this fragment has been well characterized, and its entire structure is known. Here, we propose a systematic review of TTFC by providing information about its structural features, its properties and its methods of production. We also describe the large uses of TTFC in the field of drug discovery. TTFC can therefore be considered as an attractive alternative to TTd and remarkably offers a wide range of uses, including as a carrier, delivery vector, conjugate, booster, inducer, and neuroprotector.https://www.mdpi.com/1424-8247/15/6/756tetanus toxin fragment Cstructureproductionusesvaccineneuronal protection |
| spellingShingle | Caroline Bayart Angélique Mularoni Nada Hemmani Soumeya Kerachni Joachim Jose Patrice Gouet Joseph Paladino Marc Le Borgne Tetanus Toxin Fragment C: Structure, Drug Discovery Research and Production Pharmaceuticals tetanus toxin fragment C structure production uses vaccine neuronal protection |
| title | Tetanus Toxin Fragment C: Structure, Drug Discovery Research and Production |
| title_full | Tetanus Toxin Fragment C: Structure, Drug Discovery Research and Production |
| title_fullStr | Tetanus Toxin Fragment C: Structure, Drug Discovery Research and Production |
| title_full_unstemmed | Tetanus Toxin Fragment C: Structure, Drug Discovery Research and Production |
| title_short | Tetanus Toxin Fragment C: Structure, Drug Discovery Research and Production |
| title_sort | tetanus toxin fragment c structure drug discovery research and production |
| topic | tetanus toxin fragment C structure production uses vaccine neuronal protection |
| url | https://www.mdpi.com/1424-8247/15/6/756 |
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