Gasdermin D-deficient mice are hypersensitive to acute kidney injury

Gasdermin D-deficient mice are hypersensitive to acute kidney injury

Abstract Signaling pathways of regulated necrosis, such as necroptosis and ferroptosis, contribute to acute kidney injury (AKI), but the role of pyroptosis is unclear. Pyroptosis is mediated by the pore-forming protein gasdermin D (GSDMD). Here, we report a specific pattern of GSDMD-protein expressi...

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Bibliographic Details
Main Authors: Wulf Tonnus, Francesca Maremonti, Alexia Belavgeni, Markus Latk, Yoshihiro Kusunoki, Anne Brucker, Anne von Mässenhausen, Claudia Meyer, Sophie Locke, Florian Gembardt, Kristina Beer, Paul Hoppenz, Jan U. Becker, Christian Hugo, Hans-Joachim Anders, Stefan R. Bornstein, Feng Shao, Andreas Linkermann
Format: Article
Language:English
Published: Nature Publishing Group 2022-09-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-022-05230-9

Internet

https://doi.org/10.1038/s41419-022-05230-9

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