Effects of Isoflavone-Rich NADES Extract of <i>Pueraria lobata</i> Roots and Astaxanthin-Rich <i>Phaffia rhodozyma</i> Extract on Prostate Carcinogenesis in Rats
Prostate cancer (PCa) is one of the most common male malignancies worldwide. In the current study, we evaluated the effects of a natural deep eutectic solvent (NADES) extract of <i>Pueraria lobata</i> roots rich in isoflavones (ISF) and <i>Phaffia rhodozyma</i> extract rich i...
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| Format: | Article |
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MDPI AG
2023-01-01
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| Series: | Plants |
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| Online Access: | https://www.mdpi.com/2223-7747/12/3/564 |
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| author | Alexander L. Semenov Margarita L. Tyndyk Julia D. Von Elena D. Ermakova Anastasia A. Dorofeeva Irina A. Tumanyan Ekaterina A. Radetskaya Maria N. Yurova Alexander Zherebker Alexander Yu. Gorbunov Elena I. Fedoros Andrey V. Panchenko Vladimir N. Anisimov |
| author_facet | Alexander L. Semenov Margarita L. Tyndyk Julia D. Von Elena D. Ermakova Anastasia A. Dorofeeva Irina A. Tumanyan Ekaterina A. Radetskaya Maria N. Yurova Alexander Zherebker Alexander Yu. Gorbunov Elena I. Fedoros Andrey V. Panchenko Vladimir N. Anisimov |
| author_sort | Alexander L. Semenov |
| collection | DOAJ |
| description | Prostate cancer (PCa) is one of the most common male malignancies worldwide. In the current study, we evaluated the effects of a natural deep eutectic solvent (NADES) extract of <i>Pueraria lobata</i> roots rich in isoflavones (ISF) and <i>Phaffia rhodozyma</i> extract rich in astaxanthin (ASX) on an <i>N</i>-methyl-<i>N</i>-nitrosourea plus testosterone PCa model in rats. ISF consisted of puerarin, daidzein, genistein, formononetin and other polyphenols, while ASX contained lipids and unsaturated species in addition to astaxanthin. Extracts were administered through a whole promotion period in daily doses shown by our group to successfully inhibit benign prostate hyperplasia (BPH) development — 200 mg/kg for ISF and 25 mg/kg for ASX. Though a similar effect was found for BPH processes accompanying PCa induction, the incidence of PCa in animals treated with placebo, ISF and ASX was 37%, 37% and 41%, respectively, showing no chemopreventive activity of ISF and ASX. PCa development was associated with a decrease in the Ca/Mg ratio in serum and an increase in prostate tissue. Treatment with both extracts produced a normalization effect on Ca balance in serum, which, combined with a decrease in the prostatic index, suggests some positive health effects of ISF and ASX. |
| first_indexed | 2024-03-11T09:29:46Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 2223-7747 |
| language | English |
| last_indexed | 2024-03-11T09:29:46Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Plants |
| spelling | doaj.art-c8d245c50efb4624837671c64a7290ed2023-11-16T17:44:11ZengMDPI AGPlants2223-77472023-01-0112356410.3390/plants12030564Effects of Isoflavone-Rich NADES Extract of <i>Pueraria lobata</i> Roots and Astaxanthin-Rich <i>Phaffia rhodozyma</i> Extract on Prostate Carcinogenesis in RatsAlexander L. Semenov0Margarita L. Tyndyk1Julia D. Von2Elena D. Ermakova3Anastasia A. Dorofeeva4Irina A. Tumanyan5Ekaterina A. Radetskaya6Maria N. Yurova7Alexander Zherebker8Alexander Yu. Gorbunov9Elena I. Fedoros10Andrey V. Panchenko11Vladimir N. Anisimov12N.N. Petrov National Medical Research Center of Oncology, 197758 Saint Petersburg, RussiaN.N. Petrov National Medical Research Center of Oncology, 197758 Saint Petersburg, RussiaN.N. Petrov National Medical Research Center of Oncology, 197758 Saint Petersburg, RussiaN.N. Petrov National Medical Research Center of Oncology, 197758 Saint Petersburg, RussiaN.N. Petrov National Medical Research Center of Oncology, 197758 Saint Petersburg, RussiaN.N. Petrov National Medical Research Center of Oncology, 197758 Saint Petersburg, RussiaN.N. Petrov National Medical Research Center of Oncology, 197758 Saint Petersburg, RussiaN.N. Petrov National Medical Research Center of Oncology, 197758 Saint Petersburg, RussiaSkolkovo Institute of Science and Technology, 121205 Moscow, RussiaResearch Institute of Hygiene, Occupational Pathology and Human Ecology, 188663 Saint Petersburg, RussiaN.N. Petrov National Medical Research Center of Oncology, 197758 Saint Petersburg, RussiaN.N. Petrov National Medical Research Center of Oncology, 197758 Saint Petersburg, RussiaN.N. Petrov National Medical Research Center of Oncology, 197758 Saint Petersburg, RussiaProstate cancer (PCa) is one of the most common male malignancies worldwide. In the current study, we evaluated the effects of a natural deep eutectic solvent (NADES) extract of <i>Pueraria lobata</i> roots rich in isoflavones (ISF) and <i>Phaffia rhodozyma</i> extract rich in astaxanthin (ASX) on an <i>N</i>-methyl-<i>N</i>-nitrosourea plus testosterone PCa model in rats. ISF consisted of puerarin, daidzein, genistein, formononetin and other polyphenols, while ASX contained lipids and unsaturated species in addition to astaxanthin. Extracts were administered through a whole promotion period in daily doses shown by our group to successfully inhibit benign prostate hyperplasia (BPH) development — 200 mg/kg for ISF and 25 mg/kg for ASX. Though a similar effect was found for BPH processes accompanying PCa induction, the incidence of PCa in animals treated with placebo, ISF and ASX was 37%, 37% and 41%, respectively, showing no chemopreventive activity of ISF and ASX. PCa development was associated with a decrease in the Ca/Mg ratio in serum and an increase in prostate tissue. Treatment with both extracts produced a normalization effect on Ca balance in serum, which, combined with a decrease in the prostatic index, suggests some positive health effects of ISF and ASX.https://www.mdpi.com/2223-7747/12/3/564prostate cancertestosteroneMNUNADES<i>Pueraria lobata</i><i>Phaffia rhodozyma</i> |
| spellingShingle | Alexander L. Semenov Margarita L. Tyndyk Julia D. Von Elena D. Ermakova Anastasia A. Dorofeeva Irina A. Tumanyan Ekaterina A. Radetskaya Maria N. Yurova Alexander Zherebker Alexander Yu. Gorbunov Elena I. Fedoros Andrey V. Panchenko Vladimir N. Anisimov Effects of Isoflavone-Rich NADES Extract of <i>Pueraria lobata</i> Roots and Astaxanthin-Rich <i>Phaffia rhodozyma</i> Extract on Prostate Carcinogenesis in Rats Plants prostate cancer testosterone MNU NADES <i>Pueraria lobata</i> <i>Phaffia rhodozyma</i> |
| title | Effects of Isoflavone-Rich NADES Extract of <i>Pueraria lobata</i> Roots and Astaxanthin-Rich <i>Phaffia rhodozyma</i> Extract on Prostate Carcinogenesis in Rats |
| title_full | Effects of Isoflavone-Rich NADES Extract of <i>Pueraria lobata</i> Roots and Astaxanthin-Rich <i>Phaffia rhodozyma</i> Extract on Prostate Carcinogenesis in Rats |
| title_fullStr | Effects of Isoflavone-Rich NADES Extract of <i>Pueraria lobata</i> Roots and Astaxanthin-Rich <i>Phaffia rhodozyma</i> Extract on Prostate Carcinogenesis in Rats |
| title_full_unstemmed | Effects of Isoflavone-Rich NADES Extract of <i>Pueraria lobata</i> Roots and Astaxanthin-Rich <i>Phaffia rhodozyma</i> Extract on Prostate Carcinogenesis in Rats |
| title_short | Effects of Isoflavone-Rich NADES Extract of <i>Pueraria lobata</i> Roots and Astaxanthin-Rich <i>Phaffia rhodozyma</i> Extract on Prostate Carcinogenesis in Rats |
| title_sort | effects of isoflavone rich nades extract of i pueraria lobata i roots and astaxanthin rich i phaffia rhodozyma i extract on prostate carcinogenesis in rats |
| topic | prostate cancer testosterone MNU NADES <i>Pueraria lobata</i> <i>Phaffia rhodozyma</i> |
| url | https://www.mdpi.com/2223-7747/12/3/564 |
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