Panax ginseng improves physical recovery and energy utilization on chronic fatigue in rats through the PI3K/AKT/mTOR signalling pathway
AbstractContext Panax ginseng C. A. Meyer (Araliaceae) is a tonic herb used in ancient Asia.Objective This study investigated the antifatigue effect of P. ginseng on chronic fatigue rats.Materials and methods Sprague-Dawley rats were divided into control, model and EEP (ethanol extraction of P. gins...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | Pharmaceutical Biology |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/13880209.2023.2169719 |
| _version_ | 1797234862100316160 |
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| author | Guolei Zhang BoFan Lu Enhui Wang Wei Wang Zheng Li Lili Jiao Hui Li Wei Wu |
| author_facet | Guolei Zhang BoFan Lu Enhui Wang Wei Wang Zheng Li Lili Jiao Hui Li Wei Wu |
| author_sort | Guolei Zhang |
| collection | DOAJ |
| description | AbstractContext Panax ginseng C. A. Meyer (Araliaceae) is a tonic herb used in ancient Asia.Objective This study investigated the antifatigue effect of P. ginseng on chronic fatigue rats.Materials and methods Sprague-Dawley rats were divided into control, model and EEP (ethanol extraction of P. ginseng roots) (50, 100 and 200 mg/kg) groups (n = 8). The rats were subcutaneously handled with loaded swimming once daily for 26 days, except for the control group. The animals were intragastrically treated with EEP from the 15th day. On day 30, serum, liver and muscles were collected, and the PI3K/Akt/mTOR signalling pathway was evaluated.Results The swimming times to exhaust of the rats with EEP were significantly longer than that without it. EEP spared the amount of muscle glycogen, hepatic glycogen and blood sugar under the chronic state. In addition, EEP significantly (p < 0.05) decreased serum triglycerides (1.24 ± 0.17, 1.29 ± 0.04 and 1.20 ± 0.21 vs. 1.58 ± 0.13 mmol/L) and total cholesterol (1.64 ± 0.36, 1.70 ± 0.15 and 1.41 ± 0.19 vs. 2.22 ± 0.19 mmol/L) compared to the model group. Regarding the regulation of energy, EEP had a positive impact on promoting ATPase activities and relative protein expression of the PI3K/Akt/mTOR pathway.Conclusions Our results suggested that EEP effectively relieved chronic fatigue, providing evidence that P. ginseng could be a potential dietary supplement to accelerate recovery from fatigue. |
| first_indexed | 2024-03-09T00:09:35Z |
| format | Article |
| id | doaj.art-c8d35baa195f42b693ce99c3241e0b5e |
| institution | Directory Open Access Journal |
| issn | 1388-0209 1744-5116 |
| language | English |
| last_indexed | 2024-04-24T16:38:48Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Pharmaceutical Biology |
| spelling | doaj.art-c8d35baa195f42b693ce99c3241e0b5e2024-03-29T11:10:26ZengTaylor & Francis GroupPharmaceutical Biology1388-02091744-51162023-12-0161131632310.1080/13880209.2023.2169719Panax ginseng improves physical recovery and energy utilization on chronic fatigue in rats through the PI3K/AKT/mTOR signalling pathwayGuolei Zhang0BoFan Lu1Enhui Wang2Wei Wang3Zheng Li4Lili Jiao5Hui Li6Wei Wu7Jilin Ginseng Academy, Changchun University of Chinese Medicine, Changchun, ChinaJilin Ginseng Academy, Changchun University of Chinese Medicine, Changchun, ChinaJilin Ginseng Academy, Changchun University of Chinese Medicine, Changchun, ChinaJilin Ginseng Academy, Changchun University of Chinese Medicine, Changchun, ChinaJilin Ginseng Academy, Changchun University of Chinese Medicine, Changchun, ChinaJilin Ginseng Academy, Changchun University of Chinese Medicine, Changchun, ChinaJilin Ginseng Academy, Changchun University of Chinese Medicine, Changchun, ChinaJilin Ginseng Academy, Changchun University of Chinese Medicine, Changchun, ChinaAbstractContext Panax ginseng C. A. Meyer (Araliaceae) is a tonic herb used in ancient Asia.Objective This study investigated the antifatigue effect of P. ginseng on chronic fatigue rats.Materials and methods Sprague-Dawley rats were divided into control, model and EEP (ethanol extraction of P. ginseng roots) (50, 100 and 200 mg/kg) groups (n = 8). The rats were subcutaneously handled with loaded swimming once daily for 26 days, except for the control group. The animals were intragastrically treated with EEP from the 15th day. On day 30, serum, liver and muscles were collected, and the PI3K/Akt/mTOR signalling pathway was evaluated.Results The swimming times to exhaust of the rats with EEP were significantly longer than that without it. EEP spared the amount of muscle glycogen, hepatic glycogen and blood sugar under the chronic state. In addition, EEP significantly (p < 0.05) decreased serum triglycerides (1.24 ± 0.17, 1.29 ± 0.04 and 1.20 ± 0.21 vs. 1.58 ± 0.13 mmol/L) and total cholesterol (1.64 ± 0.36, 1.70 ± 0.15 and 1.41 ± 0.19 vs. 2.22 ± 0.19 mmol/L) compared to the model group. Regarding the regulation of energy, EEP had a positive impact on promoting ATPase activities and relative protein expression of the PI3K/Akt/mTOR pathway.Conclusions Our results suggested that EEP effectively relieved chronic fatigue, providing evidence that P. ginseng could be a potential dietary supplement to accelerate recovery from fatigue.https://www.tandfonline.com/doi/10.1080/13880209.2023.2169719HerbantifatigueUPLC–MSsaponin |
| spellingShingle | Guolei Zhang BoFan Lu Enhui Wang Wei Wang Zheng Li Lili Jiao Hui Li Wei Wu Panax ginseng improves physical recovery and energy utilization on chronic fatigue in rats through the PI3K/AKT/mTOR signalling pathway Pharmaceutical Biology Herb antifatigue UPLC–MS saponin |
| title | Panax ginseng improves physical recovery and energy utilization on chronic fatigue in rats through the PI3K/AKT/mTOR signalling pathway |
| title_full | Panax ginseng improves physical recovery and energy utilization on chronic fatigue in rats through the PI3K/AKT/mTOR signalling pathway |
| title_fullStr | Panax ginseng improves physical recovery and energy utilization on chronic fatigue in rats through the PI3K/AKT/mTOR signalling pathway |
| title_full_unstemmed | Panax ginseng improves physical recovery and energy utilization on chronic fatigue in rats through the PI3K/AKT/mTOR signalling pathway |
| title_short | Panax ginseng improves physical recovery and energy utilization on chronic fatigue in rats through the PI3K/AKT/mTOR signalling pathway |
| title_sort | panax ginseng improves physical recovery and energy utilization on chronic fatigue in rats through the pi3k akt mtor signalling pathway |
| topic | Herb antifatigue UPLC–MS saponin |
| url | https://www.tandfonline.com/doi/10.1080/13880209.2023.2169719 |
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