Functional activity and peripheral insulin resistance in patients with different types of onset of diabetes mellitus
Aim. To evaluate changes in functional activity and insulin resistance (IR) in patients with different types of onset of diabetes mellitus(DM). Materials and methods. We examined 166 subjects which were subdivided into 4 study groups and 1 control group. Assessment of totalbeta-cell functional act...
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| Format: | Article |
| Language: | English |
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Endocrinology Research Centre
2012-09-01
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| Series: | Сахарный диабет |
| Subjects: | |
| Online Access: | https://www.dia-endojournals.ru/jour/article/view/6082 |
| _version_ | 1826588194175451136 |
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| author | Tatiana Vasil'evna Nikonova Elena Vladimirovna Pekareva Ivan Ivanovich Dedov |
| author_facet | Tatiana Vasil'evna Nikonova Elena Vladimirovna Pekareva Ivan Ivanovich Dedov |
| author_sort | Tatiana Vasil'evna Nikonova |
| collection | DOAJ |
| description | Aim. To evaluate changes in functional activity and insulin resistance (IR) in patients with different types of onset of diabetes mellitus(DM). Materials and methods. We examined 166 subjects which were subdivided into 4 study groups and 1 control group. Assessment of totalbeta-cell functional activity and degree of IR (according to HOMA-model) was conducted in patients with different variants of DM onsetand in the group of high risk for type 1 DM. Results. The most significant decrease in beta-cell functional activity was found in patients with type 1 diabetes mellitus (HOMA-F 8.9%).Onset of LADA (Latent autoimmune diabetes in adults) and type 2 diabetes mellitus (T2DM) was also characterized by decreasein beta-cell functional activity (HOMA-F 39.2% and 63.9%, respectively), as well as by development of IR: HOMA-IR 3.7 and 7.2,respectively. Conclusion. Clinical onset of LADA and T2DM occurs against the background of decreased beta-cell functional activity and compromisedperipheral insulin sensitivity. |
| first_indexed | 2024-03-08T15:21:43Z |
| format | Article |
| id | doaj.art-c8d421d330564d9590d80a23d5eacafa |
| institution | Directory Open Access Journal |
| issn | 2072-0351 2072-0378 |
| language | English |
| last_indexed | 2025-03-14T16:37:27Z |
| publishDate | 2012-09-01 |
| publisher | Endocrinology Research Centre |
| record_format | Article |
| series | Сахарный диабет |
| spelling | doaj.art-c8d421d330564d9590d80a23d5eacafa2025-02-21T09:29:30ZengEndocrinology Research CentreСахарный диабет2072-03512072-03782012-09-01153242610.14341/2072-0351-60826040Functional activity and peripheral insulin resistance in patients with different types of onset of diabetes mellitusTatiana Vasil'evna Nikonova0Elena Vladimirovna Pekareva1Ivan Ivanovich Dedov2Endocrinology Research Centre, MoscowEndocrinology Research Centre, MoscowEndocrinology Research Centre, MoscowAim. To evaluate changes in functional activity and insulin resistance (IR) in patients with different types of onset of diabetes mellitus(DM). Materials and methods. We examined 166 subjects which were subdivided into 4 study groups and 1 control group. Assessment of totalbeta-cell functional activity and degree of IR (according to HOMA-model) was conducted in patients with different variants of DM onsetand in the group of high risk for type 1 DM. Results. The most significant decrease in beta-cell functional activity was found in patients with type 1 diabetes mellitus (HOMA-F 8.9%).Onset of LADA (Latent autoimmune diabetes in adults) and type 2 diabetes mellitus (T2DM) was also characterized by decreasein beta-cell functional activity (HOMA-F 39.2% and 63.9%, respectively), as well as by development of IR: HOMA-IR 3.7 and 7.2,respectively. Conclusion. Clinical onset of LADA and T2DM occurs against the background of decreased beta-cell functional activity and compromisedperipheral insulin sensitivity.https://www.dia-endojournals.ru/jour/article/view/6082ladahomadiabetes mellitusladainsulin resistancehoma |
| spellingShingle | Tatiana Vasil'evna Nikonova Elena Vladimirovna Pekareva Ivan Ivanovich Dedov Functional activity and peripheral insulin resistance in patients with different types of onset of diabetes mellitus Сахарный диабет lada homa diabetes mellitus lada insulin resistance homa |
| title | Functional activity and peripheral insulin resistance in patients with different types of onset of diabetes mellitus |
| title_full | Functional activity and peripheral insulin resistance in patients with different types of onset of diabetes mellitus |
| title_fullStr | Functional activity and peripheral insulin resistance in patients with different types of onset of diabetes mellitus |
| title_full_unstemmed | Functional activity and peripheral insulin resistance in patients with different types of onset of diabetes mellitus |
| title_short | Functional activity and peripheral insulin resistance in patients with different types of onset of diabetes mellitus |
| title_sort | functional activity and peripheral insulin resistance in patients with different types of onset of diabetes mellitus |
| topic | lada homa diabetes mellitus lada insulin resistance homa |
| url | https://www.dia-endojournals.ru/jour/article/view/6082 |
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