Low-Dose Human Chorionic Gonadotropin Adjunct to an Antagonist Protocol in Assisted Reproductive Technology: a Randomized Trial Study
The aim of this study was to evaluate the outcomes of adding low-dose hCG (human chorionic gonadotropin), as an LH active supplement, to a GnRH antagonist protocol in patients undergoing assisted reproduction techniques. In this parallel-group randomized clinical trial, 137 infertile female outpatie...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Tehran University of Medical Sciences
2014-06-01
|
| Series: | Acta Medica Iranica |
| Subjects: | |
| Online Access: | https://acta.tums.ac.ir/index.php/acta/article/view/4784 |
| _version_ | 1811276480546603008 |
|---|---|
| author | Marzieh Aghahosseini Ashraf Aleyasin Habibeh Yekehtaz Ladan Kashani |
| author_facet | Marzieh Aghahosseini Ashraf Aleyasin Habibeh Yekehtaz Ladan Kashani |
| author_sort | Marzieh Aghahosseini |
| collection | DOAJ |
| description | The aim of this study was to evaluate the outcomes of adding low-dose hCG (human chorionic gonadotropin), as an LH active supplement, to a GnRH antagonist protocol in patients undergoing assisted reproduction techniques. In this parallel-group randomized clinical trial, 137 infertile female outpatients aged 20 - 39 years were randomized into two groups: hCG group and non-hCG group. All patients received r-FSH (150-300 IU) and then a GnRH-antagonist, Cetrorelix (0.25 mg/day). Concomitantly with Cetrorelix, patients in the hCG group received low-dose hCG (200 IU daily), but the patients in the non-hCG group did not. 10,000 IU Urinary hCG (10,000 IU) was injected to all patients, and ICSI was performed after oocyte retrieval. The primary outcome of this study was comparing the pregnancy rates between two study groups. Other differences between two groups such as serum estradiol concentration, fertilization rate, etc. were considered as secondary outcomes. A total of 130 patients completed this trial. No significant difference was detected between pregnancy rates of the two groups (P=0.52) as well as the fertilization, implantation and ongoing pregnancy rates (P=0.11, P=0.75 and P=0.06 respectively). The only significant difference between two groups was a higher concentration of estradiol in the hCG-treated patients (P<0.05). HCG-treated patients experienced a shorter treatment duration and a lower r-FSH required dose than the non-hCG group, but none of these differences were statistically significant (P=0.19 and P=0.10, respectively). The findings of the current study did not support advantages of adding low-dose hCG to GnRH antagonist plus r-FSH protocol in an unselected population of patients. Well-designed trials with a larger sample size for specific patients' subgroups are warranted. |
| first_indexed | 2024-04-12T23:58:19Z |
| format | Article |
| id | doaj.art-c8d67d993f4646cd95543dd2a41523c4 |
| institution | Directory Open Access Journal |
| issn | 0044-6025 1735-9694 |
| language | English |
| last_indexed | 2024-04-12T23:58:19Z |
| publishDate | 2014-06-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Acta Medica Iranica |
| spelling | doaj.art-c8d67d993f4646cd95543dd2a41523c42022-12-22T03:11:26ZengTehran University of Medical SciencesActa Medica Iranica0044-60251735-96942014-06-015264737Low-Dose Human Chorionic Gonadotropin Adjunct to an Antagonist Protocol in Assisted Reproductive Technology: a Randomized Trial StudyMarzieh Aghahosseini0Ashraf Aleyasin1Habibeh Yekehtaz2Ladan Kashani3Department of Infertility, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.Department of Infertility, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.Department of Infertility, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.Department of Infertility, Arash Hospital, Tehran University of Medical Sciences, Tehran, Iran.The aim of this study was to evaluate the outcomes of adding low-dose hCG (human chorionic gonadotropin), as an LH active supplement, to a GnRH antagonist protocol in patients undergoing assisted reproduction techniques. In this parallel-group randomized clinical trial, 137 infertile female outpatients aged 20 - 39 years were randomized into two groups: hCG group and non-hCG group. All patients received r-FSH (150-300 IU) and then a GnRH-antagonist, Cetrorelix (0.25 mg/day). Concomitantly with Cetrorelix, patients in the hCG group received low-dose hCG (200 IU daily), but the patients in the non-hCG group did not. 10,000 IU Urinary hCG (10,000 IU) was injected to all patients, and ICSI was performed after oocyte retrieval. The primary outcome of this study was comparing the pregnancy rates between two study groups. Other differences between two groups such as serum estradiol concentration, fertilization rate, etc. were considered as secondary outcomes. A total of 130 patients completed this trial. No significant difference was detected between pregnancy rates of the two groups (P=0.52) as well as the fertilization, implantation and ongoing pregnancy rates (P=0.11, P=0.75 and P=0.06 respectively). The only significant difference between two groups was a higher concentration of estradiol in the hCG-treated patients (P<0.05). HCG-treated patients experienced a shorter treatment duration and a lower r-FSH required dose than the non-hCG group, but none of these differences were statistically significant (P=0.19 and P=0.10, respectively). The findings of the current study did not support advantages of adding low-dose hCG to GnRH antagonist plus r-FSH protocol in an unselected population of patients. Well-designed trials with a larger sample size for specific patients' subgroups are warranted.https://acta.tums.ac.ir/index.php/acta/article/view/4784Low-dose hCGGnRH antagonistOvarian stimulationRecombinant FSHLuteinizing hormone |
| spellingShingle | Marzieh Aghahosseini Ashraf Aleyasin Habibeh Yekehtaz Ladan Kashani Low-Dose Human Chorionic Gonadotropin Adjunct to an Antagonist Protocol in Assisted Reproductive Technology: a Randomized Trial Study Acta Medica Iranica Low-dose hCG GnRH antagonist Ovarian stimulation Recombinant FSH Luteinizing hormone |
| title | Low-Dose Human Chorionic Gonadotropin Adjunct to an Antagonist Protocol in Assisted Reproductive Technology: a Randomized Trial Study |
| title_full | Low-Dose Human Chorionic Gonadotropin Adjunct to an Antagonist Protocol in Assisted Reproductive Technology: a Randomized Trial Study |
| title_fullStr | Low-Dose Human Chorionic Gonadotropin Adjunct to an Antagonist Protocol in Assisted Reproductive Technology: a Randomized Trial Study |
| title_full_unstemmed | Low-Dose Human Chorionic Gonadotropin Adjunct to an Antagonist Protocol in Assisted Reproductive Technology: a Randomized Trial Study |
| title_short | Low-Dose Human Chorionic Gonadotropin Adjunct to an Antagonist Protocol in Assisted Reproductive Technology: a Randomized Trial Study |
| title_sort | low dose human chorionic gonadotropin adjunct to an antagonist protocol in assisted reproductive technology a randomized trial study |
| topic | Low-dose hCG GnRH antagonist Ovarian stimulation Recombinant FSH Luteinizing hormone |
| url | https://acta.tums.ac.ir/index.php/acta/article/view/4784 |
| work_keys_str_mv | AT marziehaghahosseini lowdosehumanchorionicgonadotropinadjuncttoanantagonistprotocolinassistedreproductivetechnologyarandomizedtrialstudy AT ashrafaleyasin lowdosehumanchorionicgonadotropinadjuncttoanantagonistprotocolinassistedreproductivetechnologyarandomizedtrialstudy AT habibehyekehtaz lowdosehumanchorionicgonadotropinadjuncttoanantagonistprotocolinassistedreproductivetechnologyarandomizedtrialstudy AT ladankashani lowdosehumanchorionicgonadotropinadjuncttoanantagonistprotocolinassistedreproductivetechnologyarandomizedtrialstudy |