Homologous Sequential Immunization Using Salmonella Oral Administration Followed by an Intranasal Boost with Ferritin-Based Nanoparticles Enhanced the Humoral Immune Response against H1N1 Influenza Virus

Homologous Sequential Immunization Using Salmonella Oral Administration Followed by an Intranasal Boost with Ferritin-Based Nanoparticles Enhanced the Humoral Immune Response against H1N1 Influenza Virus

ABSTRACT The influenza virus continues to pose a great threat to public health due to the frequent variations in RNA viruses. Vaccines targeting conserved epitopes, such as the extracellular domain of the transmembrane protein M2 (M2e), a nucleoprotein, and the stem region of hemagglutinin proteins,...

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Bibliographic Details
Main Authors: Zhannan Wang, Tongyu Zhang, Futing Jia, Chongbo Ge, Yingkai He, Yawen Tian, Wenfeng Wang, Guilian Yang, Haibin Huang, Jianzhong Wang, Chunwei Shi, Wentao Yang, Xin Cao, Yan Zeng, Nan Wang, Aidong Qian, Chunfeng Wang, Yanlong Jiang
Format: Article
Language:English
Published: American Society for Microbiology 2023-06-01
Series:Microbiology Spectrum
Subjects:
influenza virus
nanoparticle vaccine
Salmonella
in situ
sequential immunization
TRM cell
Online Access:https://journals.asm.org/doi/10.1128/spectrum.00102-23

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