Experimental models for induction of liver cirrhosis in animals: a review
The liver plays a key role in the homeostatic balance of many biological processes. Cirrhosis is a syndrome in which chronic liver diseases converge, leading to hepatocellular injury, the exacerbated deposition of fibrous tissue, and eventually the disruption of the tissue architecture. The liver is...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Universidade Federal de Santa Catarina
2010-06-01
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| Series: | Biotemas |
| Subjects: | |
| Online Access: | http://www.biotemas.ufsc.br/volumes/pdf/volume232/183a190Final.pdf |
| _version_ | 1811280318764679168 |
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| author | Cristiane Carlin Passos Amanda Olivotti Ferreira Francisco Javier Hernandez Blazquez Ricardo Romão Guerra |
| author_facet | Cristiane Carlin Passos Amanda Olivotti Ferreira Francisco Javier Hernandez Blazquez Ricardo Romão Guerra |
| author_sort | Cristiane Carlin Passos |
| collection | DOAJ |
| description | The liver plays a key role in the homeostatic balance of many biological processes. Cirrhosis is a syndrome in which chronic liver diseases converge, leading to hepatocellular injury, the exacerbated deposition of fibrous tissue, and eventually the disruption of the tissue architecture. The liver is subject to potential injury by a large quantity of pharmacological agents, toxic and/or microbiological. For the study of possible treatments for cirrhosis, it is necessary to establish animal models of induction of cirrhosis, especially in laboratory rodents which mimic the cirrhotic process found in animals and humans, that have high reproducibility and uniformity, with a low mortality rate. Thus, the induction of liver cirrhosis becomes essential to the investigation of chronic liver diseases, as well as to test possible therapeutic treatments for subsequent use in human and veterinary clinics. Currently, experimental studies have been conducted to collect data about the various hepatotoxic drug effects. Carbon tetrachloride -CCl4, Thioacetamide –TAA and dimethylnitrosamine -DMN were the drugs of choice for cirrhosis induction in experimental models in this study. The model using cirrhotic TAA seems to be the best model for the reason that it produces a histological pattern closest to that of human cirrhosis, leading to lower mortality with higher reproducibility and security, despite the longer period of induction (14 weeks). |
| first_indexed | 2024-04-13T01:11:28Z |
| format | Article |
| id | doaj.art-c8dbe9e405c4462fb6895f53efa6397c |
| institution | Directory Open Access Journal |
| issn | 0103-1643 |
| language | English |
| last_indexed | 2024-04-13T01:11:28Z |
| publishDate | 2010-06-01 |
| publisher | Universidade Federal de Santa Catarina |
| record_format | Article |
| series | Biotemas |
| spelling | doaj.art-c8dbe9e405c4462fb6895f53efa6397c2022-12-22T03:09:08ZengUniversidade Federal de Santa CatarinaBiotemas0103-16432010-06-01232183190Experimental models for induction of liver cirrhosis in animals: a reviewCristiane Carlin PassosAmanda Olivotti FerreiraFrancisco Javier Hernandez BlazquezRicardo Romão GuerraThe liver plays a key role in the homeostatic balance of many biological processes. Cirrhosis is a syndrome in which chronic liver diseases converge, leading to hepatocellular injury, the exacerbated deposition of fibrous tissue, and eventually the disruption of the tissue architecture. The liver is subject to potential injury by a large quantity of pharmacological agents, toxic and/or microbiological. For the study of possible treatments for cirrhosis, it is necessary to establish animal models of induction of cirrhosis, especially in laboratory rodents which mimic the cirrhotic process found in animals and humans, that have high reproducibility and uniformity, with a low mortality rate. Thus, the induction of liver cirrhosis becomes essential to the investigation of chronic liver diseases, as well as to test possible therapeutic treatments for subsequent use in human and veterinary clinics. Currently, experimental studies have been conducted to collect data about the various hepatotoxic drug effects. Carbon tetrachloride -CCl4, Thioacetamide –TAA and dimethylnitrosamine -DMN were the drugs of choice for cirrhosis induction in experimental models in this study. The model using cirrhotic TAA seems to be the best model for the reason that it produces a histological pattern closest to that of human cirrhosis, leading to lower mortality with higher reproducibility and security, despite the longer period of induction (14 weeks).http://www.biotemas.ufsc.br/volumes/pdf/volume232/183a190Final.pdfexperimental modelsinductionliver cirrhosisratsthioacetamide |
| spellingShingle | Cristiane Carlin Passos Amanda Olivotti Ferreira Francisco Javier Hernandez Blazquez Ricardo Romão Guerra Experimental models for induction of liver cirrhosis in animals: a review Biotemas experimental models induction liver cirrhosis rats thioacetamide |
| title | Experimental models for induction of liver cirrhosis in animals: a review |
| title_full | Experimental models for induction of liver cirrhosis in animals: a review |
| title_fullStr | Experimental models for induction of liver cirrhosis in animals: a review |
| title_full_unstemmed | Experimental models for induction of liver cirrhosis in animals: a review |
| title_short | Experimental models for induction of liver cirrhosis in animals: a review |
| title_sort | experimental models for induction of liver cirrhosis in animals a review |
| topic | experimental models induction liver cirrhosis rats thioacetamide |
| url | http://www.biotemas.ufsc.br/volumes/pdf/volume232/183a190Final.pdf |
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