Generation and function of induced regulatory T cells

CD4+ CD25+ Foxp3+ regulatory T (Treg) cells are essential to the balance between pro- and anti-inflammatory responses. There are two major subsets of Treg cells, natural Treg (nTreg) cells that develop in the thymus, and induced Treg (iTreg) cells that arise in the periphery from CD4+ Foxp3– conven...

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Bibliographic Details
Main Authors: Erica G Schmitt, Calvin B Williams
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-06-01
Series:Frontiers in Immunology
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00152/full