The role of sphingosine-1-phosphate in the development and progression of Parkinson’s disease

The role of sphingosine-1-phosphate in the development and progression of Parkinson’s disease

Parkinson’s disease (PD) could be viewed as a proteinopathy caused by changes in lipids, whereby modifications in lipid metabolism may lead to protein alterations, such as the accumulation of alpha-synuclein (α-syn), ultimately resulting in neurodegeneration. Although the loss of dopaminergic neuron...

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Bibliographic Details
Main Authors:	Wang Wang, Yang Zhao, Guoxue Zhu
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-12-01
Series:	Frontiers in Cellular Neuroscience
Subjects:	Parkinson’s disease sphingosine-1-phosphate S1P metabolism S1P modulators cellular neuropathology
Online Access:	https://www.frontiersin.org/articles/10.3389/fncel.2023.1288437/full

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