The immune status of patients with frontal bone trauma with implant SYNTEKIST used in surgical treatment
Aim. To determine the influence of a biocomposite on the state of the immune system of patients with trauma to the frontal bone at 1 month after surgical treatment. Materials and Methods. 20 patients with frontal bone fracture treated surgically with and without a SYNEKIST biocomposite were exam...
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| Format: | Article |
| Language: | English |
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Ukrainian Society of Ophthalmologists
2019-08-01
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| Series: | Journal of Ophthalmology |
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| Online Access: | https://www.ozhurnal.com/en/archive/2019/4/8-fulltext |
| _version_ | 1797383222324101120 |
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| author | О.D.Bondarchuk V.V. Kishchuk О.F. Melnykov М.D. Tymchenko N.D. Didyk |
| author_facet | О.D.Bondarchuk V.V. Kishchuk О.F. Melnykov М.D. Tymchenko N.D. Didyk |
| author_sort | О.D.Bondarchuk |
| collection | DOAJ |
| description | Aim. To determine the influence of a biocomposite on the state of the immune system of patients with trauma to the frontal bone at 1 month after surgical treatment.
Materials and Methods. 20 patients with frontal bone fracture treated surgically with and without a SYNEKIST biocomposite were examined; 10 patients served as control. Immunoglobulins M, G, A, and E were determined in the blood serum using enzyme-linked immunosorbent assay. We also determined the content of prodefensin (lactoferrin, an indicator of the acute phase of inflammation), interleukins IL-1?, and interleukin-10.
Results. On presentation and during the first days, the patients with trauma to the frontal bone had a decreased level of IgM which, however, reached the control level and was practically the same in both groups. There were no changes in other immunoglobulins in a month. The level of pro-inflammatory Il-a was increased on admission with a significant decrease within the first month in both treatment approaches. The on-admission level of pro-inflammatory cytokines did not differ significantly from the control while its level increased in the patients undergone the surgical treatment using a biocomposite material. The level of lactoferrin decreased to normal ranges in both treatment approaches.
Conclusions. The advantage of the surgical treatment using a biocomposite material lies in the restoration of the IgM level and activation of anti-inflammatory mechanisms, Il-10, in particular, in 1 month. |
| first_indexed | 2024-03-08T21:17:47Z |
| format | Article |
| id | doaj.art-c8e2526ced7a4263aa9f1e2fe516f587 |
| institution | Directory Open Access Journal |
| issn | 2412-8740 |
| language | English |
| last_indexed | 2024-03-08T21:17:47Z |
| publishDate | 2019-08-01 |
| publisher | Ukrainian Society of Ophthalmologists |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj.art-c8e2526ced7a4263aa9f1e2fe516f5872023-12-21T14:48:49ZengUkrainian Society of OphthalmologistsJournal of Ophthalmology2412-87402019-08-014384210.31288/oftalmolzh201943842The immune status of patients with frontal bone trauma with implant SYNTEKIST used in surgical treatmentО.D.Bondarchuk0V.V. Kishchuk1О.F. Melnykov2М.D. Tymchenko3N.D. Didyk4Mykola Pyrohov Vinnytsia National Medical University;Mykola Pyrohov Vinnytsia Regional HospitalMykola Pyrohov Vinnytsia National Medical UniversityProf. O.S. Kolomiychenko Otolaryngology Institute of NAMSProf. O.S. Kolomiychenko Otolaryngology Institute of NAMSProf. O.S. Kolomiychenko Otolaryngology Institute of NAMSAim. To determine the influence of a biocomposite on the state of the immune system of patients with trauma to the frontal bone at 1 month after surgical treatment. Materials and Methods. 20 patients with frontal bone fracture treated surgically with and without a SYNEKIST biocomposite were examined; 10 patients served as control. Immunoglobulins M, G, A, and E were determined in the blood serum using enzyme-linked immunosorbent assay. We also determined the content of prodefensin (lactoferrin, an indicator of the acute phase of inflammation), interleukins IL-1?, and interleukin-10. Results. On presentation and during the first days, the patients with trauma to the frontal bone had a decreased level of IgM which, however, reached the control level and was practically the same in both groups. There were no changes in other immunoglobulins in a month. The level of pro-inflammatory Il-a was increased on admission with a significant decrease within the first month in both treatment approaches. The on-admission level of pro-inflammatory cytokines did not differ significantly from the control while its level increased in the patients undergone the surgical treatment using a biocomposite material. The level of lactoferrin decreased to normal ranges in both treatment approaches. Conclusions. The advantage of the surgical treatment using a biocomposite material lies in the restoration of the IgM level and activation of anti-inflammatory mechanisms, Il-10, in particular, in 1 month. https://www.ozhurnal.com/en/archive/2019/4/8-fulltexttrauma to the frontal boneimmunoglobulinsinterleukinsbiocomposite syntekist |
| spellingShingle | О.D.Bondarchuk V.V. Kishchuk О.F. Melnykov М.D. Tymchenko N.D. Didyk The immune status of patients with frontal bone trauma with implant SYNTEKIST used in surgical treatment Journal of Ophthalmology trauma to the frontal bone immunoglobulins interleukins biocomposite syntekist |
| title | The immune status of patients with frontal bone trauma with implant SYNTEKIST used in surgical treatment |
| title_full | The immune status of patients with frontal bone trauma with implant SYNTEKIST used in surgical treatment |
| title_fullStr | The immune status of patients with frontal bone trauma with implant SYNTEKIST used in surgical treatment |
| title_full_unstemmed | The immune status of patients with frontal bone trauma with implant SYNTEKIST used in surgical treatment |
| title_short | The immune status of patients with frontal bone trauma with implant SYNTEKIST used in surgical treatment |
| title_sort | immune status of patients with frontal bone trauma with implant syntekist used in surgical treatment |
| topic | trauma to the frontal bone immunoglobulins interleukins biocomposite syntekist |
| url | https://www.ozhurnal.com/en/archive/2019/4/8-fulltext |
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