Predictors of Progression and Mortality in Patients with Chronic Hypersensitivity Pneumonitis: Retrospective Analysis of Registry of Fibrosing Interstitial Lung Diseases
Hypersensitivity pneumonitis (HP) is an interstitial lung disease (ILD) resulting from an immune-mediated response in susceptible and sensitized individuals to a large variety of inhaled antigens. Chronic HP with a fibrotic phenotype is characterized by disease progression and a dismal prognosis. Th...
| Main Authors: | , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-02-01
|
| Series: | Life |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2075-1729/13/2/467 |
| _version_ | 1797619857456365568 |
|---|---|
| author | Natalia V. Trushenko Olga A. Suvorova Ekaterina S. Pershina Galina V. Nekludova Svetlana Yu. Chikina Iuliia A. Levina Andrey L. Chernyaev Maria V. Samsonova Igor E. Tyurin Malika Kh. Mustafina Andrey I. Yaroshetskiy Nikita B. Nadtochiy Zamira M. Merzhoeva Anna A. Proshkina Sergey N. Avdeev |
| author_facet | Natalia V. Trushenko Olga A. Suvorova Ekaterina S. Pershina Galina V. Nekludova Svetlana Yu. Chikina Iuliia A. Levina Andrey L. Chernyaev Maria V. Samsonova Igor E. Tyurin Malika Kh. Mustafina Andrey I. Yaroshetskiy Nikita B. Nadtochiy Zamira M. Merzhoeva Anna A. Proshkina Sergey N. Avdeev |
| author_sort | Natalia V. Trushenko |
| collection | DOAJ |
| description | Hypersensitivity pneumonitis (HP) is an interstitial lung disease (ILD) resulting from an immune-mediated response in susceptible and sensitized individuals to a large variety of inhaled antigens. Chronic HP with a fibrotic phenotype is characterized by disease progression and a dismal prognosis. The aim of this study was to identify predictors of progression and mortality in patients with chronic HP in real clinical practice. Materials and methods: This retrospective, multicenter, observational study used data from a registry of 1355 patients with fibrosing ILDs. The study included 292 patients diagnosed with chronic HP based on the conclusion of a multidisciplinary discussion (MDD). Results: The patients were divided into groups with progressive (92 (30.3%) patients) and nonprogressive pulmonary fibrosis (200 (69.7%) patients). The most significant predictors of adverse outcomes were a DLco < 50% predicted, an SpO2 at the end of a six-minute walk test (6-MWT) < 85%, and a GAP score ≥ 4 points. Conclusion: Pulmonary fibrosis and a progressive fibrotic phenotype are common in patients with chronic HP. Early detection of the predictors of an adverse prognosis of chronic HP is necessary for the timely initiation of antifibrotic therapy. |
| first_indexed | 2024-03-11T08:32:49Z |
| format | Article |
| id | doaj.art-c8e2ecc3e5bb4507bd2f8cff16460508 |
| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-11T08:32:49Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj.art-c8e2ecc3e5bb4507bd2f8cff164605082023-11-16T21:41:41ZengMDPI AGLife2075-17292023-02-0113246710.3390/life13020467Predictors of Progression and Mortality in Patients with Chronic Hypersensitivity Pneumonitis: Retrospective Analysis of Registry of Fibrosing Interstitial Lung DiseasesNatalia V. Trushenko0Olga A. Suvorova1Ekaterina S. Pershina2Galina V. Nekludova3Svetlana Yu. Chikina4Iuliia A. Levina5Andrey L. Chernyaev6Maria V. Samsonova7Igor E. Tyurin8Malika Kh. Mustafina9Andrey I. Yaroshetskiy10Nikita B. Nadtochiy11Zamira M. Merzhoeva12Anna A. Proshkina13Sergey N. Avdeev14Pulmonology Department, Sechenov First Moscow State Medical University (Sechenov University), Healthcare Ministry of Russia, Trubetskaya St. 8, Build. 2, 119991 Moscow, RussiaPulmonology Department, Sechenov First Moscow State Medical University (Sechenov University), Healthcare Ministry of Russia, Trubetskaya St. 8, Build. 2, 119991 Moscow, RussiaPulmonology Department, Sechenov First Moscow State Medical University (Sechenov University), Healthcare Ministry of Russia, Trubetskaya St. 8, Build. 2, 119991 Moscow, RussiaPulmonology Department, Sechenov First Moscow State Medical University (Sechenov University), Healthcare Ministry of Russia, Trubetskaya St. 8, Build. 2, 119991 Moscow, RussiaPulmonology Department, Sechenov First Moscow State Medical University (Sechenov University), Healthcare Ministry of Russia, Trubetskaya St. 8, Build. 2, 119991 Moscow, RussiaPulmonology Department, Sechenov First Moscow State Medical University (Sechenov University), Healthcare Ministry of Russia, Trubetskaya St. 8, Build. 2, 119991 Moscow, RussiaPulmonology Scientific Research Institute, Federal Medical and Biological Agency of Russian Federation, Orekhovyy Boulevard 28, 115682 Moscow, RussiaPulmonology Scientific Research Institute, Federal Medical and Biological Agency of Russian Federation, Orekhovyy Boulevard 28, 115682 Moscow, RussiaRussian Federal Academy of Continued Medical Education, Healthcare Ministry of Russia, Barrikadnaya St. 2/1, Build. 1, 123995 Moscow, RussiaPulmonology Department, Sechenov First Moscow State Medical University (Sechenov University), Healthcare Ministry of Russia, Trubetskaya St. 8, Build. 2, 119991 Moscow, RussiaPulmonology Department, Sechenov First Moscow State Medical University (Sechenov University), Healthcare Ministry of Russia, Trubetskaya St. 8, Build. 2, 119991 Moscow, RussiaChelyabinsk Regional Clinical Hospital, Vorovskogo St. 70, 454076 Chelyabinsk, RussiaPulmonology Department, Sechenov First Moscow State Medical University (Sechenov University), Healthcare Ministry of Russia, Trubetskaya St. 8, Build. 2, 119991 Moscow, RussiaPulmonology Department, Sechenov First Moscow State Medical University (Sechenov University), Healthcare Ministry of Russia, Trubetskaya St. 8, Build. 2, 119991 Moscow, RussiaPulmonology Department, Sechenov First Moscow State Medical University (Sechenov University), Healthcare Ministry of Russia, Trubetskaya St. 8, Build. 2, 119991 Moscow, RussiaHypersensitivity pneumonitis (HP) is an interstitial lung disease (ILD) resulting from an immune-mediated response in susceptible and sensitized individuals to a large variety of inhaled antigens. Chronic HP with a fibrotic phenotype is characterized by disease progression and a dismal prognosis. The aim of this study was to identify predictors of progression and mortality in patients with chronic HP in real clinical practice. Materials and methods: This retrospective, multicenter, observational study used data from a registry of 1355 patients with fibrosing ILDs. The study included 292 patients diagnosed with chronic HP based on the conclusion of a multidisciplinary discussion (MDD). Results: The patients were divided into groups with progressive (92 (30.3%) patients) and nonprogressive pulmonary fibrosis (200 (69.7%) patients). The most significant predictors of adverse outcomes were a DLco < 50% predicted, an SpO2 at the end of a six-minute walk test (6-MWT) < 85%, and a GAP score ≥ 4 points. Conclusion: Pulmonary fibrosis and a progressive fibrotic phenotype are common in patients with chronic HP. Early detection of the predictors of an adverse prognosis of chronic HP is necessary for the timely initiation of antifibrotic therapy.https://www.mdpi.com/2075-1729/13/2/467hypersensitivity pneumonitisprogressive pulmonary fibrosispulmonary fibrosisinterstitial lung diseasesprognosismortality |
| spellingShingle | Natalia V. Trushenko Olga A. Suvorova Ekaterina S. Pershina Galina V. Nekludova Svetlana Yu. Chikina Iuliia A. Levina Andrey L. Chernyaev Maria V. Samsonova Igor E. Tyurin Malika Kh. Mustafina Andrey I. Yaroshetskiy Nikita B. Nadtochiy Zamira M. Merzhoeva Anna A. Proshkina Sergey N. Avdeev Predictors of Progression and Mortality in Patients with Chronic Hypersensitivity Pneumonitis: Retrospective Analysis of Registry of Fibrosing Interstitial Lung Diseases Life hypersensitivity pneumonitis progressive pulmonary fibrosis pulmonary fibrosis interstitial lung diseases prognosis mortality |
| title | Predictors of Progression and Mortality in Patients with Chronic Hypersensitivity Pneumonitis: Retrospective Analysis of Registry of Fibrosing Interstitial Lung Diseases |
| title_full | Predictors of Progression and Mortality in Patients with Chronic Hypersensitivity Pneumonitis: Retrospective Analysis of Registry of Fibrosing Interstitial Lung Diseases |
| title_fullStr | Predictors of Progression and Mortality in Patients with Chronic Hypersensitivity Pneumonitis: Retrospective Analysis of Registry of Fibrosing Interstitial Lung Diseases |
| title_full_unstemmed | Predictors of Progression and Mortality in Patients with Chronic Hypersensitivity Pneumonitis: Retrospective Analysis of Registry of Fibrosing Interstitial Lung Diseases |
| title_short | Predictors of Progression and Mortality in Patients with Chronic Hypersensitivity Pneumonitis: Retrospective Analysis of Registry of Fibrosing Interstitial Lung Diseases |
| title_sort | predictors of progression and mortality in patients with chronic hypersensitivity pneumonitis retrospective analysis of registry of fibrosing interstitial lung diseases |
| topic | hypersensitivity pneumonitis progressive pulmonary fibrosis pulmonary fibrosis interstitial lung diseases prognosis mortality |
| url | https://www.mdpi.com/2075-1729/13/2/467 |
| work_keys_str_mv | AT nataliavtrushenko predictorsofprogressionandmortalityinpatientswithchronichypersensitivitypneumonitisretrospectiveanalysisofregistryoffibrosinginterstitiallungdiseases AT olgaasuvorova predictorsofprogressionandmortalityinpatientswithchronichypersensitivitypneumonitisretrospectiveanalysisofregistryoffibrosinginterstitiallungdiseases AT ekaterinaspershina predictorsofprogressionandmortalityinpatientswithchronichypersensitivitypneumonitisretrospectiveanalysisofregistryoffibrosinginterstitiallungdiseases AT galinavnekludova predictorsofprogressionandmortalityinpatientswithchronichypersensitivitypneumonitisretrospectiveanalysisofregistryoffibrosinginterstitiallungdiseases AT svetlanayuchikina predictorsofprogressionandmortalityinpatientswithchronichypersensitivitypneumonitisretrospectiveanalysisofregistryoffibrosinginterstitiallungdiseases AT iuliiaalevina predictorsofprogressionandmortalityinpatientswithchronichypersensitivitypneumonitisretrospectiveanalysisofregistryoffibrosinginterstitiallungdiseases AT andreylchernyaev predictorsofprogressionandmortalityinpatientswithchronichypersensitivitypneumonitisretrospectiveanalysisofregistryoffibrosinginterstitiallungdiseases AT mariavsamsonova predictorsofprogressionandmortalityinpatientswithchronichypersensitivitypneumonitisretrospectiveanalysisofregistryoffibrosinginterstitiallungdiseases AT igoretyurin predictorsofprogressionandmortalityinpatientswithchronichypersensitivitypneumonitisretrospectiveanalysisofregistryoffibrosinginterstitiallungdiseases AT malikakhmustafina predictorsofprogressionandmortalityinpatientswithchronichypersensitivitypneumonitisretrospectiveanalysisofregistryoffibrosinginterstitiallungdiseases AT andreyiyaroshetskiy predictorsofprogressionandmortalityinpatientswithchronichypersensitivitypneumonitisretrospectiveanalysisofregistryoffibrosinginterstitiallungdiseases AT nikitabnadtochiy predictorsofprogressionandmortalityinpatientswithchronichypersensitivitypneumonitisretrospectiveanalysisofregistryoffibrosinginterstitiallungdiseases AT zamirammerzhoeva predictorsofprogressionandmortalityinpatientswithchronichypersensitivitypneumonitisretrospectiveanalysisofregistryoffibrosinginterstitiallungdiseases AT annaaproshkina predictorsofprogressionandmortalityinpatientswithchronichypersensitivitypneumonitisretrospectiveanalysisofregistryoffibrosinginterstitiallungdiseases AT sergeynavdeev predictorsofprogressionandmortalityinpatientswithchronichypersensitivitypneumonitisretrospectiveanalysisofregistryoffibrosinginterstitiallungdiseases |