THE INVESTIGATION OF CYTOTOXIC EFFECT OF CINNAMOMUM ZEYLANICUM EXTRACTS ON HUMAN BREAST CANCER CELL LINE (MCF-7)
Cinnamon is one of the oldest herbal medicine that has been historically known to possess has anticancer property. In this study, the cytotoxicity of the cinnamon extracts towards human breast cancer cell line (MCF-7) was investigated. Cinnamomum zeylanicum was extracted using Soxhlet and water ex...
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| Format: | Article |
| Language: | English |
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Zibeline International
2017-12-01
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| Series: | Science Heritage Journal |
| Subjects: | |
| Online Access: | https://zibelinepub.com/archives/2gws2017/2gws2017-23-28.pdf |
| _version_ | 1818908956455600128 |
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| author | Widya Ainatun |
| author_facet | Widya Ainatun |
| author_sort | Widya |
| collection | DOAJ |
| description | Cinnamon is one of the oldest herbal medicine that has been historically known to possess has anticancer property.
In this study, the cytotoxicity of the cinnamon extracts towards human breast cancer cell line (MCF-7) was
investigated. Cinnamomum zeylanicum was extracted using Soxhlet and water extraction methods, producing 7.06%
and 2.54% of yield respectively. The extracts were analysed using Gas Chromatography/ Mass Spectrometry
(GCMS) and it was found that cinnamaldehyde is the major constituents which contribute more than 70% of the
major constituents. The cytotoxicity of C. zeylanicum extract against MCF-7 was determined through colorimetric
MTT assay at 24 and 48 hours of incubation periods. The IC50 values of Soxhlet extract were 58 µg/ml and 140 µg/ml
while the IC50 values of water extract were 9 mg/ml and 4.8 mg/ml, at 24 and 48 hours treatment respectively. In
conclusion, C. zeylanicum extracts has been confirmed to have cytotoxic effect towards MCF-7 cell line in different
concentrations at two different incubation periods. |
| first_indexed | 2024-12-19T22:19:15Z |
| format | Article |
| id | doaj.art-c8e32d72b35b4cea830b74fba10ab297 |
| institution | Directory Open Access Journal |
| issn | 2521-0858 2521-0866 |
| language | English |
| last_indexed | 2024-12-19T22:19:15Z |
| publishDate | 2017-12-01 |
| publisher | Zibeline International |
| record_format | Article |
| series | Science Heritage Journal |
| spelling | doaj.art-c8e32d72b35b4cea830b74fba10ab2972022-12-21T20:03:41ZengZibeline InternationalScience Heritage Journal2521-08582521-08662017-12-0112232810.26480/gws.02.2017.23.28THE INVESTIGATION OF CYTOTOXIC EFFECT OF CINNAMOMUM ZEYLANICUM EXTRACTS ON HUMAN BREAST CANCER CELL LINE (MCF-7)Widya 0Ainatun1Abd Wahab Natrah AdzmiCinnamon is one of the oldest herbal medicine that has been historically known to possess has anticancer property. In this study, the cytotoxicity of the cinnamon extracts towards human breast cancer cell line (MCF-7) was investigated. Cinnamomum zeylanicum was extracted using Soxhlet and water extraction methods, producing 7.06% and 2.54% of yield respectively. The extracts were analysed using Gas Chromatography/ Mass Spectrometry (GCMS) and it was found that cinnamaldehyde is the major constituents which contribute more than 70% of the major constituents. The cytotoxicity of C. zeylanicum extract against MCF-7 was determined through colorimetric MTT assay at 24 and 48 hours of incubation periods. The IC50 values of Soxhlet extract were 58 µg/ml and 140 µg/ml while the IC50 values of water extract were 9 mg/ml and 4.8 mg/ml, at 24 and 48 hours treatment respectively. In conclusion, C. zeylanicum extracts has been confirmed to have cytotoxic effect towards MCF-7 cell line in different concentrations at two different incubation periods.https://zibelinepub.com/archives/2gws2017/2gws2017-23-28.pdfCinnamomum zeylanicumSoxhlet extractwater extractcytotoxicityGCMSMTT assayMCF-7IC50. |
| spellingShingle | Widya Ainatun THE INVESTIGATION OF CYTOTOXIC EFFECT OF CINNAMOMUM ZEYLANICUM EXTRACTS ON HUMAN BREAST CANCER CELL LINE (MCF-7) Science Heritage Journal Cinnamomum zeylanicum Soxhlet extract water extract cytotoxicity GCMS MTT assay MCF-7 IC50. |
| title | THE INVESTIGATION OF CYTOTOXIC EFFECT OF CINNAMOMUM ZEYLANICUM EXTRACTS ON HUMAN BREAST CANCER CELL LINE (MCF-7) |
| title_full | THE INVESTIGATION OF CYTOTOXIC EFFECT OF CINNAMOMUM ZEYLANICUM EXTRACTS ON HUMAN BREAST CANCER CELL LINE (MCF-7) |
| title_fullStr | THE INVESTIGATION OF CYTOTOXIC EFFECT OF CINNAMOMUM ZEYLANICUM EXTRACTS ON HUMAN BREAST CANCER CELL LINE (MCF-7) |
| title_full_unstemmed | THE INVESTIGATION OF CYTOTOXIC EFFECT OF CINNAMOMUM ZEYLANICUM EXTRACTS ON HUMAN BREAST CANCER CELL LINE (MCF-7) |
| title_short | THE INVESTIGATION OF CYTOTOXIC EFFECT OF CINNAMOMUM ZEYLANICUM EXTRACTS ON HUMAN BREAST CANCER CELL LINE (MCF-7) |
| title_sort | investigation of cytotoxic effect of cinnamomum zeylanicum extracts on human breast cancer cell line mcf 7 |
| topic | Cinnamomum zeylanicum Soxhlet extract water extract cytotoxicity GCMS MTT assay MCF-7 IC50. |
| url | https://zibelinepub.com/archives/2gws2017/2gws2017-23-28.pdf |
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