Antioxidant therapy for patients with oral lichen planus: A systematic review and meta-analysis
Aims: This study aimed to systematically review the efficacy and safety of antioxidants for patients with Oral lichen planus (OLP).Methods: Databases, including PubMed, Web of Science, Cochrane Library, Embase, and Google Scholar, were searched up to 30 April 2022, for randomized controlled trials o...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2022.1030893/full |
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| author | Jie Bao Chu Chen Jiayu Yan Jiayu Yan Jiayu Yan Yueqiang Wen Jiamin Bian Mengting Xu Qin Liang Qingmei He |
| author_facet | Jie Bao Chu Chen Jiayu Yan Jiayu Yan Jiayu Yan Yueqiang Wen Jiamin Bian Mengting Xu Qin Liang Qingmei He |
| author_sort | Jie Bao |
| collection | DOAJ |
| description | Aims: This study aimed to systematically review the efficacy and safety of antioxidants for patients with Oral lichen planus (OLP).Methods: Databases, including PubMed, Web of Science, Cochrane Library, Embase, and Google Scholar, were searched up to 30 April 2022, for randomized controlled trials on the antioxidant therapy of OLP. The following endpoints were analyzed: pain score, clinical score, pain resolution rate, clinical resolution rate, and adverse effects.Results: A total of 19 studies met the inclusion criteria, and 17 studies with 704 patients were included in the meta-analysis. The findings showed that antioxidant therapy could significantly reduce the pain score [standardized mean difference −0.72 (−1.36, −0.07), P = 0.03, I2 = 87%, PI2 < 0.00001] and clinical score [SMD −2.06 (−3.06, −1.06), P < 0.0001, I2 = 94%, PI2 < 0.00001] of patients with OLP and improve the pain resolution rate [risk ratio (RR) 1.15 (1.01, 1.31), P = 0.04, I2 = 45%, PI2 = 0.09] and clinical resolution rate [RR 1.40 (1.10, 1.78), P = 0.006, I2 = 72%, PI2 = 0.002].Conclusion: The study demonstrated that antioxidant therapy was beneficial for patients with OLP, and antioxidants might be used to treat OLP.Systematic Review Registration:https://clinicaltrials.gov/, identifier CRD4202233715. |
| first_indexed | 2024-04-12T10:41:58Z |
| format | Article |
| id | doaj.art-c8e3cb896a2b4aa58fe596a85a8db075 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-04-12T10:41:58Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-c8e3cb896a2b4aa58fe596a85a8db0752022-12-22T03:36:35ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122022-11-011310.3389/fphar.2022.10308931030893Antioxidant therapy for patients with oral lichen planus: A systematic review and meta-analysisJie Bao0Chu Chen1Jiayu Yan2Jiayu Yan3Jiayu Yan4Yueqiang Wen5Jiamin Bian6Mengting Xu7Qin Liang8Qingmei He9School of Clinical Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaSchool of Clinical Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaSchool of Clinical Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaDepartment of Stomatology, Sichuan Integrated Traditional and Western Medicine Hospital, Chengdu, ChinaSchool of Stomatology, North Sichuan Medical College, Nanchong, ChinaSchool of Basic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaSchool of Stomatology, North Sichuan Medical College, Nanchong, ChinaDepartment of Stomatology, Sichuan Integrated Traditional and Western Medicine Hospital, Chengdu, ChinaDepartment of Stomatology, Pengzhou Hospital of Traditional Chinese Medicine, Pengzhou, ChinaDepartment of Neurological, Chongqing Shi Yong Chuan Hospital of Traditional Chinese Medicine, Chongqing, ChinaAims: This study aimed to systematically review the efficacy and safety of antioxidants for patients with Oral lichen planus (OLP).Methods: Databases, including PubMed, Web of Science, Cochrane Library, Embase, and Google Scholar, were searched up to 30 April 2022, for randomized controlled trials on the antioxidant therapy of OLP. The following endpoints were analyzed: pain score, clinical score, pain resolution rate, clinical resolution rate, and adverse effects.Results: A total of 19 studies met the inclusion criteria, and 17 studies with 704 patients were included in the meta-analysis. The findings showed that antioxidant therapy could significantly reduce the pain score [standardized mean difference −0.72 (−1.36, −0.07), P = 0.03, I2 = 87%, PI2 < 0.00001] and clinical score [SMD −2.06 (−3.06, −1.06), P < 0.0001, I2 = 94%, PI2 < 0.00001] of patients with OLP and improve the pain resolution rate [risk ratio (RR) 1.15 (1.01, 1.31), P = 0.04, I2 = 45%, PI2 = 0.09] and clinical resolution rate [RR 1.40 (1.10, 1.78), P = 0.006, I2 = 72%, PI2 = 0.002].Conclusion: The study demonstrated that antioxidant therapy was beneficial for patients with OLP, and antioxidants might be used to treat OLP.Systematic Review Registration:https://clinicaltrials.gov/, identifier CRD4202233715.https://www.frontiersin.org/articles/10.3389/fphar.2022.1030893/fullantioxidantlichen planusoraloral lichen planusoral mucosal diseasemeta-analysis |
| spellingShingle | Jie Bao Chu Chen Jiayu Yan Jiayu Yan Jiayu Yan Yueqiang Wen Jiamin Bian Mengting Xu Qin Liang Qingmei He Antioxidant therapy for patients with oral lichen planus: A systematic review and meta-analysis Frontiers in Pharmacology antioxidant lichen planus oral oral lichen planus oral mucosal disease meta-analysis |
| title | Antioxidant therapy for patients with oral lichen planus: A systematic review and meta-analysis |
| title_full | Antioxidant therapy for patients with oral lichen planus: A systematic review and meta-analysis |
| title_fullStr | Antioxidant therapy for patients with oral lichen planus: A systematic review and meta-analysis |
| title_full_unstemmed | Antioxidant therapy for patients with oral lichen planus: A systematic review and meta-analysis |
| title_short | Antioxidant therapy for patients with oral lichen planus: A systematic review and meta-analysis |
| title_sort | antioxidant therapy for patients with oral lichen planus a systematic review and meta analysis |
| topic | antioxidant lichen planus oral oral lichen planus oral mucosal disease meta-analysis |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2022.1030893/full |
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