Repeatability and Comparability of Retinal Blood Vessel Caliber Measurements by OCTA
Background: To investigate the repeatability in vessel caliber measurements by optical coherence tomography angiography (OCTA). Methods: In this prospective study, 28 patients (47 eyes) underwent sequential OCTA imaging of the optic nerve head and macula. Two independent masked graders measured vess...
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| Format: | Article |
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MDPI AG
2023-07-01
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| Series: | Vision |
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| Online Access: | https://www.mdpi.com/2411-5150/7/3/48 |
| _version_ | 1827722987518820352 |
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| author | Joby Tsai Samuel Asanad Martha Whiting Xuemin Zhang Laurence Magder Osamah Saeedi |
| author_facet | Joby Tsai Samuel Asanad Martha Whiting Xuemin Zhang Laurence Magder Osamah Saeedi |
| author_sort | Joby Tsai |
| collection | DOAJ |
| description | Background: To investigate the repeatability in vessel caliber measurements by optical coherence tomography angiography (OCTA). Methods: In this prospective study, 28 patients (47 eyes) underwent sequential OCTA imaging of the optic nerve head and macula. Two independent masked graders measured vessel caliber for sequential images of the optic nerve head and macula. The average vessel width was determined and variability between graders and images. Results: A total of 8400 measurements of 420 vessels from 84 OCTA images were included in the analysis. Overall, inter-grader agreement was excellent (ICC 0.90). The coefficient of variation (CoV) for all repeated OCTA images was 0.10. Greater glaucoma severity, older age, macular location, and diagnosis of diabetes were associated with thinner vessels (<i>p</i> < 0.05). CoV was higher in the peripapillary region (0.07) as compared to the macula (0.15). ICC was high for all subgroups except for the macula (ICC = 0.72). Conclusions: Overall, the repeatability of vessel caliber measurements by OCTA was high and variability low. There was greater variability in the measurement of macular vessels, possibly due to technical limitations in acquiring accurate vessel widths for smaller macular vessels. |
| first_indexed | 2024-03-10T21:51:54Z |
| format | Article |
| id | doaj.art-c8e3df4cff5a4813abdbe1213f686f4c |
| institution | Directory Open Access Journal |
| issn | 2411-5150 |
| language | English |
| last_indexed | 2024-03-10T21:51:54Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vision |
| spelling | doaj.art-c8e3df4cff5a4813abdbe1213f686f4c2023-11-19T13:24:21ZengMDPI AGVision2411-51502023-07-01734810.3390/vision7030048Repeatability and Comparability of Retinal Blood Vessel Caliber Measurements by OCTAJoby Tsai0Samuel Asanad1Martha Whiting2Xuemin Zhang3Laurence Magder4Osamah Saeedi5Department of Ophthalmology, Broward Health, Deerfield Beach, FL 33064, USADepartment of Ophthalmology and Visual Sciences, University of Maryland, Baltimore, MD 21201, USADepartment of Ophthalmology and Visual Sciences, University of Maryland, Baltimore, MD 21201, USADepartment of Ophthalmology and Visual Sciences, University of Maryland, Baltimore, MD 21201, USADepartment of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD 21201, USADepartment of Ophthalmology and Visual Sciences, University of Maryland, Baltimore, MD 21201, USABackground: To investigate the repeatability in vessel caliber measurements by optical coherence tomography angiography (OCTA). Methods: In this prospective study, 28 patients (47 eyes) underwent sequential OCTA imaging of the optic nerve head and macula. Two independent masked graders measured vessel caliber for sequential images of the optic nerve head and macula. The average vessel width was determined and variability between graders and images. Results: A total of 8400 measurements of 420 vessels from 84 OCTA images were included in the analysis. Overall, inter-grader agreement was excellent (ICC 0.90). The coefficient of variation (CoV) for all repeated OCTA images was 0.10. Greater glaucoma severity, older age, macular location, and diagnosis of diabetes were associated with thinner vessels (<i>p</i> < 0.05). CoV was higher in the peripapillary region (0.07) as compared to the macula (0.15). ICC was high for all subgroups except for the macula (ICC = 0.72). Conclusions: Overall, the repeatability of vessel caliber measurements by OCTA was high and variability low. There was greater variability in the measurement of macular vessels, possibly due to technical limitations in acquiring accurate vessel widths for smaller macular vessels.https://www.mdpi.com/2411-5150/7/3/48optical coherence tomography angiography (OCTA)primary open-angle glaucoma (POAG)repeatabilityvessel caliber |
| spellingShingle | Joby Tsai Samuel Asanad Martha Whiting Xuemin Zhang Laurence Magder Osamah Saeedi Repeatability and Comparability of Retinal Blood Vessel Caliber Measurements by OCTA Vision optical coherence tomography angiography (OCTA) primary open-angle glaucoma (POAG) repeatability vessel caliber |
| title | Repeatability and Comparability of Retinal Blood Vessel Caliber Measurements by OCTA |
| title_full | Repeatability and Comparability of Retinal Blood Vessel Caliber Measurements by OCTA |
| title_fullStr | Repeatability and Comparability of Retinal Blood Vessel Caliber Measurements by OCTA |
| title_full_unstemmed | Repeatability and Comparability of Retinal Blood Vessel Caliber Measurements by OCTA |
| title_short | Repeatability and Comparability of Retinal Blood Vessel Caliber Measurements by OCTA |
| title_sort | repeatability and comparability of retinal blood vessel caliber measurements by octa |
| topic | optical coherence tomography angiography (OCTA) primary open-angle glaucoma (POAG) repeatability vessel caliber |
| url | https://www.mdpi.com/2411-5150/7/3/48 |
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