Mammillary bodies and fornix fibers are injured in heart failure
Cognitive abnormalities, including memory deficits, are common in heart failure (HF). Brain structures, including the hippocampus, fornix, and thalamus participate in memory processing, and most show structural injury and functional deficits in HF. The mammillary bodies and fornix play essential rol...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2009-02-01
|
| Series: | Neurobiology of Disease |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0969996108002593 |
| _version_ | 1830193376342835200 |
|---|---|
| author | Rajesh Kumar Mary A. Woo Bramley V.X. Birrer Paul M. Macey Gregg C. Fonarow Michele A. Hamilton Ronald M. Harper |
| author_facet | Rajesh Kumar Mary A. Woo Bramley V.X. Birrer Paul M. Macey Gregg C. Fonarow Michele A. Hamilton Ronald M. Harper |
| author_sort | Rajesh Kumar |
| collection | DOAJ |
| description | Cognitive abnormalities, including memory deficits, are common in heart failure (HF). Brain structures, including the hippocampus, fornix, and thalamus participate in memory processing, and most show structural injury and functional deficits in HF. The mammillary bodies and fornix play essential roles in spatial and working memory processing, interact with other structures, and may also be injured in HF. We assessed mammillary body volumes and cross-sectional fornix areas in 17 HF and 50 control subjects using high-resolution T1-weighted magnetic resonance images. Mammillary body volumes and fornix cross-sectional areas were significantly reduced bilaterally in HF, and these differences remained after controlling age, gender, and intracranial volume. Mammillary body and fornix injury may contribute to the compromised spatial and working memory deficits in HF. Pathological processes eliciting the damage may include injury accompanying hypoxic/ischemic processes in pathologic HF perfusion and breathing, and thiamine deficiency accompanying diuretic use and nutritional mal-absorption in the condition. |
| first_indexed | 2024-12-18T00:12:13Z |
| format | Article |
| id | doaj.art-c8e4e9a7dcab493f81c752aaa23c3a1d |
| institution | Directory Open Access Journal |
| issn | 1095-953X |
| language | English |
| last_indexed | 2024-12-18T00:12:13Z |
| publishDate | 2009-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Neurobiology of Disease |
| spelling | doaj.art-c8e4e9a7dcab493f81c752aaa23c3a1d2022-12-21T21:27:39ZengElsevierNeurobiology of Disease1095-953X2009-02-01332236242Mammillary bodies and fornix fibers are injured in heart failureRajesh Kumar0Mary A. Woo1Bramley V.X. Birrer2Paul M. Macey3Gregg C. Fonarow4Michele A. Hamilton5Ronald M. Harper6Department of Neurobiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USAUCLA School of Nursing, University of California at Los Angeles, 700 Tiverton Avenue, Los Angeles, CA 90095-1702, USA; Corresponding author. Fax: +1 310 206 7433.Department of Neurobiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USAUCLA School of Nursing, University of California at Los Angeles, 700 Tiverton Avenue, Los Angeles, CA 90095-1702, USA; Brain Research Institute, Los Angeles, CA 90095, USADivision of Cardiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USADivision of Cardiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USADepartment of Neurobiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA; Brain Research Institute, Los Angeles, CA 90095, USACognitive abnormalities, including memory deficits, are common in heart failure (HF). Brain structures, including the hippocampus, fornix, and thalamus participate in memory processing, and most show structural injury and functional deficits in HF. The mammillary bodies and fornix play essential roles in spatial and working memory processing, interact with other structures, and may also be injured in HF. We assessed mammillary body volumes and cross-sectional fornix areas in 17 HF and 50 control subjects using high-resolution T1-weighted magnetic resonance images. Mammillary body volumes and fornix cross-sectional areas were significantly reduced bilaterally in HF, and these differences remained after controlling age, gender, and intracranial volume. Mammillary body and fornix injury may contribute to the compromised spatial and working memory deficits in HF. Pathological processes eliciting the damage may include injury accompanying hypoxic/ischemic processes in pathologic HF perfusion and breathing, and thiamine deficiency accompanying diuretic use and nutritional mal-absorption in the condition.http://www.sciencedirect.com/science/article/pii/S0969996108002593Anterior thalamusMagnetic resonance imagingHippocampusThiamineIschemiaMemory |
| spellingShingle | Rajesh Kumar Mary A. Woo Bramley V.X. Birrer Paul M. Macey Gregg C. Fonarow Michele A. Hamilton Ronald M. Harper Mammillary bodies and fornix fibers are injured in heart failure Neurobiology of Disease Anterior thalamus Magnetic resonance imaging Hippocampus Thiamine Ischemia Memory |
| title | Mammillary bodies and fornix fibers are injured in heart failure |
| title_full | Mammillary bodies and fornix fibers are injured in heart failure |
| title_fullStr | Mammillary bodies and fornix fibers are injured in heart failure |
| title_full_unstemmed | Mammillary bodies and fornix fibers are injured in heart failure |
| title_short | Mammillary bodies and fornix fibers are injured in heart failure |
| title_sort | mammillary bodies and fornix fibers are injured in heart failure |
| topic | Anterior thalamus Magnetic resonance imaging Hippocampus Thiamine Ischemia Memory |
| url | http://www.sciencedirect.com/science/article/pii/S0969996108002593 |
| work_keys_str_mv | AT rajeshkumar mammillarybodiesandfornixfibersareinjuredinheartfailure AT maryawoo mammillarybodiesandfornixfibersareinjuredinheartfailure AT bramleyvxbirrer mammillarybodiesandfornixfibersareinjuredinheartfailure AT paulmmacey mammillarybodiesandfornixfibersareinjuredinheartfailure AT greggcfonarow mammillarybodiesandfornixfibersareinjuredinheartfailure AT micheleahamilton mammillarybodiesandfornixfibersareinjuredinheartfailure AT ronaldmharper mammillarybodiesandfornixfibersareinjuredinheartfailure |