Contemporary outcomes of surgical resection for chest wall chondrosarcomaCentral MessagePerspective
Objective: Chondrosarcoma is the most common primary malignant chest wall tumor and is historically associated with poor prognosis. Recommendations regarding surgical excision are on the basis of small, single-institution studies. We used a large national database to assess outcomes of surgery for c...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-03-01
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| Series: | JTCVS Open |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666273623000104 |
| _version_ | 1797860377533349888 |
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| author | Christine E. Alvarado, MD Jonathan D. Rice, MD Philip A. Linden, MD Anuja L. Sarode, MPH Sean J. Halloran, BS Jillian Sinopoli, DO Christopher W. Towe, MD |
| author_facet | Christine E. Alvarado, MD Jonathan D. Rice, MD Philip A. Linden, MD Anuja L. Sarode, MPH Sean J. Halloran, BS Jillian Sinopoli, DO Christopher W. Towe, MD |
| author_sort | Christine E. Alvarado, MD |
| collection | DOAJ |
| description | Objective: Chondrosarcoma is the most common primary malignant chest wall tumor and is historically associated with poor prognosis. Recommendations regarding surgical excision are on the basis of small, single-institution studies. We used a large national database to assess outcomes of surgery for chest wall chondrosarcoma (CWC) hypothesizing that surgical excision remains standard of care. Methods: The National Cancer Databases for bone and soft tissue were merged to identify patients with chondrosarcoma from 2004 to 2018. Clinical and demographic characteristics of CWC were compared with chondrosarcoma from other sites. The primary outcome was overall survival described using Kaplan–Meier estimate. Univariable and multivariable Cox analysis was used to determine risk factors for poor survival among CWC patients who underwent surgery. Multivariable analysis of predictors of margin status was performed because of worse prognosis associated with positive margins. Results: Among 11,925 patients with chondrosarcoma, 1934 (16.2%) had a CWC. Relative to other sites, CWC was associated with older age, male sex, White race, surgical resection, and care at a nonacademic institution. CWC was associated with 1-, 3-, 5-, and 10-year survival of 91.5%, 82.0%, 75.5%, and 62.7%, respectively. In univariable analysis, survival was associated with surgery (hazard ratio, 0.02; P < .001) and adversely affected by positive margins (hazard ratio, 2.66; P < .001). Multivariable analysis showed larger tumor size was independently associated with increased risk for positive margins (odds ratio, 1.04; 95% CI, 1.011-1.075). Conclusions: CWC represents a different cohort of patients relative to chondrosarcoma from other sites. Surgical excision remains the optimal treatment, and positive margins are associated with poor prognosis. |
| first_indexed | 2024-04-09T21:44:53Z |
| format | Article |
| id | doaj.art-c8e5215ae5e54f9aa9e21b7e9af9e0ef |
| institution | Directory Open Access Journal |
| issn | 2666-2736 |
| language | English |
| last_indexed | 2024-04-09T21:44:53Z |
| publishDate | 2023-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | JTCVS Open |
| spelling | doaj.art-c8e5215ae5e54f9aa9e21b7e9af9e0ef2023-03-25T05:15:34ZengElsevierJTCVS Open2666-27362023-03-0113435443Contemporary outcomes of surgical resection for chest wall chondrosarcomaCentral MessagePerspectiveChristine E. Alvarado, MD0Jonathan D. Rice, MD1Philip A. Linden, MD2Anuja L. Sarode, MPH3Sean J. Halloran, BS4Jillian Sinopoli, DO5Christopher W. Towe, MD6Division of Thoracic and Esophageal Surgery, Department of Surgery, University Hospitals Cleveland Medical Center and Case Western Reserve University School of Medicine, Cleveland, OhioDivision of Thoracic and Esophageal Surgery, Department of Surgery, University Hospitals Cleveland Medical Center and Case Western Reserve University School of Medicine, Cleveland, OhioDivision of Thoracic and Esophageal Surgery, Department of Surgery, University Hospitals Cleveland Medical Center and Case Western Reserve University School of Medicine, Cleveland, OhioUH-RISES: Research in Surgical Outcomes and Effectiveness, Department of Surgery, University Hospitals Cleveland Medical Center and Case Western Reserve University School of Medicine, Cleveland, OhioThe University of Toledo College of Medicine and Life Sciences, Toledo, OhioDivision of Thoracic and Esophageal Surgery, Department of Surgery, University Hospitals Cleveland Medical Center and Case Western Reserve University School of Medicine, Cleveland, OhioDivision of Thoracic and Esophageal Surgery, Department of Surgery, University Hospitals Cleveland Medical Center and Case Western Reserve University School of Medicine, Cleveland, Ohio; Address for reprints: Christopher W. Towe, MD, 11100 Euclid Ave, Cleveland, OH 44106-501.Objective: Chondrosarcoma is the most common primary malignant chest wall tumor and is historically associated with poor prognosis. Recommendations regarding surgical excision are on the basis of small, single-institution studies. We used a large national database to assess outcomes of surgery for chest wall chondrosarcoma (CWC) hypothesizing that surgical excision remains standard of care. Methods: The National Cancer Databases for bone and soft tissue were merged to identify patients with chondrosarcoma from 2004 to 2018. Clinical and demographic characteristics of CWC were compared with chondrosarcoma from other sites. The primary outcome was overall survival described using Kaplan–Meier estimate. Univariable and multivariable Cox analysis was used to determine risk factors for poor survival among CWC patients who underwent surgery. Multivariable analysis of predictors of margin status was performed because of worse prognosis associated with positive margins. Results: Among 11,925 patients with chondrosarcoma, 1934 (16.2%) had a CWC. Relative to other sites, CWC was associated with older age, male sex, White race, surgical resection, and care at a nonacademic institution. CWC was associated with 1-, 3-, 5-, and 10-year survival of 91.5%, 82.0%, 75.5%, and 62.7%, respectively. In univariable analysis, survival was associated with surgery (hazard ratio, 0.02; P < .001) and adversely affected by positive margins (hazard ratio, 2.66; P < .001). Multivariable analysis showed larger tumor size was independently associated with increased risk for positive margins (odds ratio, 1.04; 95% CI, 1.011-1.075). Conclusions: CWC represents a different cohort of patients relative to chondrosarcoma from other sites. Surgical excision remains the optimal treatment, and positive margins are associated with poor prognosis.http://www.sciencedirect.com/science/article/pii/S2666273623000104thoracic surgerychondrosarcomachest wall chondrosarcomasurgery |
| spellingShingle | Christine E. Alvarado, MD Jonathan D. Rice, MD Philip A. Linden, MD Anuja L. Sarode, MPH Sean J. Halloran, BS Jillian Sinopoli, DO Christopher W. Towe, MD Contemporary outcomes of surgical resection for chest wall chondrosarcomaCentral MessagePerspective JTCVS Open thoracic surgery chondrosarcoma chest wall chondrosarcoma surgery |
| title | Contemporary outcomes of surgical resection for chest wall chondrosarcomaCentral MessagePerspective |
| title_full | Contemporary outcomes of surgical resection for chest wall chondrosarcomaCentral MessagePerspective |
| title_fullStr | Contemporary outcomes of surgical resection for chest wall chondrosarcomaCentral MessagePerspective |
| title_full_unstemmed | Contemporary outcomes of surgical resection for chest wall chondrosarcomaCentral MessagePerspective |
| title_short | Contemporary outcomes of surgical resection for chest wall chondrosarcomaCentral MessagePerspective |
| title_sort | contemporary outcomes of surgical resection for chest wall chondrosarcomacentral messageperspective |
| topic | thoracic surgery chondrosarcoma chest wall chondrosarcoma surgery |
| url | http://www.sciencedirect.com/science/article/pii/S2666273623000104 |
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